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Preliminary study of substantia nigra analysis by tensorial feature extraction
PurposeParkinson disease (PD) is a common progressive neurodegenerative disorder in our ageing society. Early-stage PD biomarkers are desired for...
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Secondary neurodegeneration of ipsilateral substantia nigra in acute ischemic stroke
IntroductionSecondary neurodegeneration after stroke is a complex phenomenon affecting remote and synaptically linked cerebral areas. The involvement...
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Effects of acupuncture and moxibustion on PINK1/Parkin signaling pathway in substantia nigra of Thy1-αSyn transgenic mice with Parkinson disease
ObjectiveTo observe the effects of acupuncture and moxibustion on phosphatase and PTEN-induced putative kinase 1 (PINK1)/Parkin signaling pathway in...
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Regional age-related changes of neuromelanin and iron in the substantia nigra based on neuromelanin accumulation and iron deposition
ObjectivesTo investigate age-related neuromelanin signal variation and iron content changes in the subregions of substantia nigra (SN) using...
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Echogenicity and size of substantia nigra on transcranial sonography (TCS) in patients with attention-deficit/hyperactivity disorder and healthy children aged 6–12 years: a comparative study
BackgroundAttention-deficit/hyperactivity disorder (ADHD) is one of the most common neuropsychiatric disorders. Children with ADHD may experience...
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An investigation of neuromelanin distribution in substantia nigra and locus coeruleus in patients with Parkinson’s disease using neuromelanin-sensitive MRI
Loss of neuromelanin in the midbrain is known in Parkinson’s disease(PD), which can now be directly detected by neuromelanin-sensitive MRI(NM-MRI)....
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Association of emotional and behavioral problems with the development of the substantia nigra, subthalamic nucleus, and red nucleus volumes and asymmetries from childhood to adolescence: A longitudinal cohort study
The substantia nigra (SN), subthalamic nucleus (STN), and red nucleus (RN) have been widely studied as important biomarkers of degenerative diseases....
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Collateral projections from the ventral tegmental area/substantia nigra pars compacta to the nucleus accumbens and insular cortex in the rat
Midbrain dopaminergic (DAergic) regions including ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) are involved in diverse brain...
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Diffusion basis spectrum imaging detects pathological alterations in substantia nigra and white matter tracts with early-stage Parkinson’s disease
ObjectivesUsing diffusion basis spectrum imaging (DBSI) to examine the microstructural changes in the substantia nigra (SN) and global white matter...
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Evidence for upregulation of excitatory synaptic transmission in the substantia nigra in Schizophrenia: a postmortem ultrastructural study
The dopamine hypothesis of schizophrenia suggests that psychotic symptoms originate from dysregulation of dopaminergic activity, which may be...
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Acceleration of neuromelanin-sensitive MRI sequences in the substantia nigra using standard MRI options
PurposeNeuromelanin MRI (NM-MRI) is applied as a proxy measurement of dopaminergic functioning of the substantia nigra pars compacta (SN). To...
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Neuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substanti...
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Transcranial sonography depicts a larger substantia nigra echogenic area in renal transplant patients on calcineurin inhibitors than on rapamycin
BackgroundAfter kidney transplantation neurologic manifestations may develop, including Parkinson’s disease (PD). An enlarged substantia nigra (SN)...
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Coordinated modification in expression levels of HSPA1A/B, DGKH, and NOTCH2 in Parkinson’s patients’ blood and substantia nigra as a diagnostic sign: the transcriptomes’ relationship
BackgroundDiagnosis of Parkinson’s disease (PD) is associated with a vast number of challenges. This study aimed to assess the overlap of PD...
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Substantia nigra neuromelanin magnetic resonance imaging in patients with different subtypes of Parkinson disease
Neuromelanin (NM) is a dark pigment that mainly exists in neurons of the substantia nigra pars compacta (SNc). In Parkinson disease (PD) patients, NM...
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Neuromelanin accumulation in Substantia nigra in vascular parkinsonism
Vascular parkinsonism (VaP) is a term used to describe a parkinsonism of vascular cause. However, only ischemic or hemorrhagic lesions in the...
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The applied value in brain gray matter nuclei of patients with early-stage Parkinson’s disease : a study based on multiple magnetic resonance imaging techniques
PurposeThis study compares the observation efficiency of brain gray matter nuclei of patients with early-stage Parkinson’s disease among various...
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Neuromelanin imaging analyses of the substantia nigra in patients with Machado-Joseph disease
PurposeMachado-Joseph disease (MJD/SCA3) is the most frequent spinocerebellar ataxia worldwide. Pathological studies revealed less melanin-containing...
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Neuroprotective effects of morroniside from Cornus officinalis sieb. Et zucc against Parkinson’s disease via inhibiting oxidative stress and ferroptosis
Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer disease accompanied by the death of dopaminergic...
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