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An examination of sleep spindle metrics in the Sleep Heart Health Study: superiority of automated spindle detection over total sigma power in assessing age-related spindle decline
BackgroundSleep spindle activity is commonly estimated by measuring sigma power during stage 2 non-rapid eye movement (NREM2) sleep. However,...
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Sleep spindle architecture associated with distinct clinical phenotypes in older adults at risk for dementia
Sleep spindles are a hallmark of non-REM sleep and play a fundamental role in memory consolidation. Alterations in these spindles are emerging as...
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Δ3-tubulin impairs mitotic spindle morphology and increases nuclear size in pancreatic cancer cells
Cancer cell proliferation is affected by post-translational modifications of tubulin. Especially, overexpression or depletion of enzymes for...
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A Thalamocortical Perspective on Sleep Spindle Alterations in Neurodevelopmental Disorders
Purpose of ReviewNeurodevelopmental disorders are a group of conditions that affect the development and function of the nervous system, typically...
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Unusual Presentation of Tonsillar Spindle Cell Neoplasm: A Case Report
Spindle cell neoplasm of the tonsil are rare (Minami et al. in Am J Otolaryngol 29(2):123–125, 2008) and can be difficult to diagnose due to their...
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Mycobacterial Spindle Cell Pseudotumor of the Nasal Cavity
BackgroundMycobacterial spindle cell pseudotumor (MSCP) represents an uncommon tumor-like proliferation associated with nontuberculous mycobacterial...
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Spindle Cell Sarcoma of the Maxilla: A Rare Entity, Case Report, and Review of the Literature
Spindle cell sarcoma (SCS) is a malignancy, with the most recent Surveillance, Epidemiology, and End Results (SEER) data citing a total of 250...
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Spindle Cell Tumors of the Sinonasal Tract: A Diagnostic Update with Focus on Ancillary Workup
Spindle cell neoplasms arising in the head and neck may be challenging to recognize due to their relative rarity. While underlying molecular...
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NET1 is a critical regulator of spindle assembly and actin dynamics in mouse oocytes
BackgroundNeuroepithelial transforming gene 1 (NET1) is a RhoA subfamily guanine nucleotide exchange factor that governs a wide array of biological...
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A case of spindle and giant cell-type undifferentiated carcinoma of the extrahepatic bile duct
Spindle and giant cell type undifferentiated carcinoma of the extrahepatic bile duct is an uncommon malignancy. We report a case involving the common...
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A rare presentation of orbital spindle cell carcinoma a case report and brief review of the literature
BackgroundTo describe a case of orbital spindle cell carcinoma which presented with limbal ischemia and briefly review the literature.
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Mucinous tubular and spindle renal cell carcinoma revealed by a trauma of the kidney: a case report
BackgroundMucinous tubular and spindle cell carcinoma is a rare renal tumor. It has been recognized as a distinct entity in the 2004 World Health...
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The mitotic spindle-related seven-gene predicts the prognosis and immune microenvironment of lung adenocarcinoma
PurposeAbnormalities in the mitotic spindle have been linked to a variety of cancers. Data on their role in the onset, progression, and treatment of...
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Clear and Spindle Cell Dedifferentiation in Ameloblastic Carcinoma: A Case Report on a Uncommon Phenomenon
Ameloblastic carcinoma is a rare malignant neoplasm with characteristic histopathological features that are directed towards an aggressive surgical...
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Vitrification of Human Oocytes Before or After Rescue-IVM Does not Impair Maturation Kinetics but Induces Meiotic Spindle Alterations
Cryopreservation of in vitro matured oocytes is still considered as an experimental alternative to mature oocyte vitrification after ovarian...
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Epithelioid and spindle rhabdomyosarcoma with TFCP2 rearrangement in abdominal wall: a distinctive entity with poor prognosis
BackgroundEpithelioid and spindle rhabdomyosarcoma (ES-RMS) with TFCP2 rearrangement is a recently discovered rare variant of rhabdomyosarcoma...
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Granulation tissue-like spindle cell (sarcomatoid) carcinoma of the head and neck: a deceptively bland-looking underdiagnosed malignancy
The diagnosis of head and neck spindle cell squamous carcinoma (SC-SCC) is often challenging. Lesions with a prominent inflammatory infiltrate and...
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Primary spindle cell tumor originating from the liver that was difficult to diagnose
BackgroundIt has been reported that hepatocellular carcinoma (HCC) with spindle cell tumor accounts for 1.8% of all HCCs, but spindle cell tumors...
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Challenges in diagnosing canine spindle cell tumours using immunohistochemistry, illustrated by three nonpigmented malignant cases from the nictitating membrane
BackgroundNonpigmented malignant spindle cell tumours of the membrana nictitans are rare in dogs. In twenty-three years only three cases have been...
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Spindle function and Wnt pathway inhibition by PBX1 to suppress tumor progression via downregulating DCDC2 in colorectal cancer
PBX1 is a transcription factor that regulates a variety of genes, involved in intracellular lipid metabolism, cell proliferation, and other pathways....
