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Application of Single-Cell Genomics in Cardiovascular Research
Cardiovascular diseases (CVDs) are the leading cause of death in the global world. The emergence of single-cell technologies has greatly facilitated...
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Map** the human kidney using single-cell genomics
The field of single-cell genomics and spatial technologies is rapidly evolving and has already provided unprecedented insights into complex tissues....
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The single-cell opioid responses in the context of HIV (SCORCH) consortium
Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with...
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Cryptosporidium Genomics — Current Understanding, Advances, and Applications
Purpose of ReviewHere we highlight the significant contribution that genomics-based approaches have had on the field of Cryptosp oridium research and...
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Spatial genomics: map** human steatotic liver disease
Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as non-alcoholic fatty liver disease) is a leading cause of chronic...
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Powering single-cell genomics to unravel circulating tumour cell subpopulations in non-small cell lung cancer patients
BackgroundCirculating tumour cells (CTCs) are attractive “liquid biopsy” candidates that could provide insights into the different phenotypes of...
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Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer
Advances in chimeric antigen receptor (CAR)-T cell therapy have significantly improved clinical outcomes of patients with relapsed or refractory...
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Profiling joint tissues at single-cell resolution: advances and insights
Advances in the profiling of human joint tissues at single-cell resolution have provided unique insights into the organization and function of these...
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Single-cell sequencing analysis of peripheral blood in patients with moyamoya disease
BackgroundAt present, the etiology of moyamoya disease is not clear, and it is necessary to explore the mechanism of its occurrence and development....
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CRISPR screening in hematology research: from bulk to single-cell level
The CRISPR genome editing technology has revolutionized the way gene function is studied. Genome editing can be achieved in single genes or for...
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Single-cell analysis reveals alterations in cellular composition and cell-cell communication associated with airway inflammation and remodeling in asthma
BackgroundAsthma is a heterogeneous disease characterized by airway inflammation and remodeling, whose pathogenetic complexity was associated with...
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Charting the cellular landscape of pulmonary arterial hypertension through single-cell omics
This review examines how single-cell omics technologies, particularly single-cell RNA sequencing (scRNAseq), enhance our understanding of pulmonary...
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Precision oncology in neurofibromatosis type 1: quantification of differential sensitivity to selumetinib in plexiform neurofibromas using single-cell RNA sequencing
PurposeSelumetinib is an FDA-approved targeted therapy for plexiform neurofibromas in neurofibromatosis type 1(NF1) with durable response rates seen...
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Single-cell sequencing of tumour infiltrating T cells efficiently identifies tumour-specific T cell receptors based on the T cell activation score
Adoptively transferred T cell receptor-engineered T cells are a promising cancer treatment strategy, and the identification of tumour-specific TCRs...
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Practical Compass of Single-Cell RNA-Seq Analysis
Purpose of ReviewThis review paper provides step-by-step instructions on the fundamental process, from handling fastq datasets to illustrating plots...
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Single-cell transcriptomics of the ocular anterior segment: a comprehensive review
Elucidating the cellular and genetic composition of ocular tissues is essential for uncovering the pathophysiology of ocular diseases. Since the...
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Advancing skeletal health and disease research with single-cell RNA sequencing
Orthopedic conditions have emerged as global health concerns, impacting approximately 1.7 billion individuals worldwide. However, the limited...
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Tumor heterogeneity and immune-evasive T follicular cell lymphoma phenotypes at single-cell resolution
T follicular helper (T FH ) cell lymphomas (TFHLs) are characterized by T FH -like properties and accompanied by substantial immune-cell infiltration...
