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Development of a “Geo-Tagged” tumor sample registry: intra-operative linkage of sample location to imaging
PurposeThere is a growing body of literature documenting glioma heterogeneity in terms of radiographic, histologic, molecular, and genetic...
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Sample size calculations for indirect standardization
Indirect standardization, and its associated parameter the standardized incidence ratio, is a commonly-used tool in hospital profiling for comparing...
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Strategies for Recruiting a Diverse Postpartum Survey Sample
BackgroundData from diverse populations are needed to inform interventions for maternal health equity. However, research recruitment of postpartum...
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Sample size calculation for data reliability and diagnostic performance: a go-to review
Sample size, namely the number of subjects that should be included in a study to reach the desired endpoint and statistical power, is a fundamental...
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Delineating functional and molecular impact of ex vivo sample handling in precision medicine
Consistent handling of samples is crucial for achieving reproducible molecular and functional testing results in translational research. Here, we...
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Sample Size Requirements to Test Subgroup-Specific Treatment Effects in Cluster-Randomized Trials
Cluster-randomized trials (CRTs) often allocate intact clusters of participants to treatment or control conditions and are increasingly used to...
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Autoencoders for sample size estimation for fully connected neural network classifiers
Sample size estimation is a crucial step in experimental design but is understudied in the context of deep learning. Currently, estimating the...
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Sample size determination for point-of-care COVID-19 diagnostic tests: a Bayesian approach
BackgroundIn a pandemic setting, it is critical to evaluate and deploy accurate diagnostic tests rapidly. This relies heavily on the sample size...
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Belief in science and climate anxiety: findings from a quota-sample
AimTo date, no studies exist investigating whether belief in science is associated with climate anxiety. Thus, our goal was to examine the link...
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Minimum important difference is minimally important in sample size calculations
Performing a sample size calculation for a randomized controlled trial requires specifying an assumed benefit (that is, the mean improvement in...
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Sample size determination for external pilot cluster randomised trials with binary feasibility outcomes: a tutorial
Justifying sample size for a pilot trial is a reporting requirement, but few pilot trials report a clear rationale for their chosen sample size....
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Gut microbiota and chronic rhinosinusitis: a two-sample Mendelian randomization study
BackgroundThe nasal cavity and gut are interconnected, both housing a rich natural microbiome. Gut microbiota may interact with nasal microbiota and...
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The importance of clinical importance when determining the target difference in sample size calculations
Recently, it was argued that clinically important differences should play no role in sample size calculations. Instead, it was proposed that sample...
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Sample size calculations for continuous outcomes in clinical nutrition
In nutrition research, sample size calculations for continuous outcomes are important for the planning phase of many randomized trials and could also...
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Whole exome sequencing in a sample of Egyptian patients with covert cerebral small vessel disease
BackgroundCovert cerebral small vessel disease (cCSVD) is associated with many age-related morbidities with little available data regarding the...
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Diabetes and osteoporosis: a two-sample mendelian randomization study
BackgroundThe effects on bone mineral density (BMD)/fracture between type 1 (T1D) and type 2 (T2D) diabetes are unknown. Therefore, we aimed to...
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Bayesian network modeling of patterns of antibiotic cross-resistance by bacterial sample source
BackgroundAntimicrobial resistance is a major healthcare burden, aggravated when it extends to multiple drugs. While cross-resistance is well-studied...
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Causal association between helicobacter pylori and atherosclerosis: a two-sample Mendelian randomization
BackgroundHelicobacter pylori (H. pylori), according to a number of recent observational studies, is connected to atherosclerosis (AS). However, the...
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Psychological distress and uterine fibroids: a bidirectional two-sample mendelian randomization study
BackgroundObservational data indicates a connection between emotional discomfort, such as anxiety and depression, and uterine fibroids (UFs)....
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Stroke and frailty index: a two-sample Mendelian randomisation study
IntroductionPrevious observational studies have found an increased risk of frailty in patients with stroke. However, evidence of a causal...
