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Exploring the nigrostriatal and digestive interplays in Parkinson’s disease using dynamic total-body [11C]CFT PET/CT
PurposeDynamic total-body imaging enables new perspectives to investigate the potential relationship between the central and peripheral regions....
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[18F]F13640: a selective agonist PET radiopharmaceutical for imaging functional 5-HT1A receptors in humans
PurposeF13640 (a.k.a. befiradol, NLX-112) is a highly selective 5-HT 1A receptor ligand that was selected as a PET radiopharmaceutical-candidate...
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Validation and test–retest repeatability performance of parametric methods for [11C]UCB-J PET
[ 11 C]UCB-J is a PET radioligand that binds to the presynaptic vesicle glycoprotein 2A. Therefore, [ 11 C]UCB-J PET may serve as an in vivo marker of...
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Measurement of changes in endogenous serotonin level by positron emission tomography with [18F]altanserin
ObjectivePositron emission tomography (PET) has been used to investigate changes in the concentration of endogenous neurotransmitters. Recently, this...
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Kinetic Modelling and Test–Retest Reproducibility for the Dopamine D1R Radioligand [11C]SCH23390 in Healthy and Diseased Mice
PurposeOur aim in this study was to compare different non-invasive pharmacokinetic models and assess test–retest reproducibility of the radioligand [
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Quantification of SV2A Binding in Rodent Brain Using [18F]SynVesT-1 and PET Imaging
PurposeSynapse loss is a hallmark of Alzheimer’s disease (AD) and correlates with cognitive decline. The validation of a noninvasive in vivo imaging...
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Effect of Shortening the Scan Duration on Quantitative Accuracy of [18F]Flortaucipir Studies
PurposeDynamic positron emission tomography (PET) protocols allow for accurate quantification of [ 18 F]flortaucipir-specific binding. However,...
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Non-invasive Standardised Uptake Value for Verification of the Use of Previously Validated Reference Region for [18F]Flortaucipir and [18F]Florbetapir Brain PET Studies
PurposeThe simplified reference tissue model (SRTM) is commonly applied for the quantification of brain positron emission tomography (PET) studies,...
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Evaluation of novel 3D-printed and conventional thermoplastic stereotactic high-precision patient fixation masks for radiotherapy
PurposeFor stereotactic radiation therapy of intracranial malignancies, a patient’s head needs to be immobilized with high accuracy. Fixation devices...
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Multivariate analysis of PET pharmacokinetic parameters improves inferential efficiency
PurposeIn positron emission tomography quantification, multiple pharmacokinetic parameters are typically estimated from each time activity curve....
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Effect of scan-time shortening on the 11C-PHNO binding potential to dopamine D3 receptor in humans and test–retest reliability
Objective11 C-PHNO is a PET radioligand most specific to dopamine D 3 receptor (D 3 R). The long scan duration of 120 min used in quantification of 11 C-P...
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Glioblastoma PET/MRI: kinetic investigation of [18F]rhPSMA-7.3, [18F]FET and [18F]fluciclovine in an orthotopic mouse model of cancer
PurposeGlioblastoma multiforme (GBM) is the most common glioma and standard therapies can only slightly prolong the survival. Neo-vascularization is...
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Pharmacokinetic evaluation of [18F]PR04.MZ for PET/CT imaging and quantification of dopamine transporters in the human brain
PurposeDopamine transporters (DAT) modulate pre-synaptic dopamine and physiological functions such as movement and reward. DAT also mirrors disease...
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Dopamine and fear memory formation in the human amygdala
Learning which environmental cues that predict danger is crucial for survival and accomplished through Pavlovian fear conditioning. In humans and...
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GABAA Receptors in the Mongolian Gerbil: a PET Study Using [18F]Flumazenil to Determine Receptor Binding in Young and Old Animals
PurposePlastic changes in the central auditory system involving the GABAergic system accompany age-related hearing loss. Such processes can be...
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The relationship between dose and serotonin transporter occupancy of antidepressants—a systematic review
Brain imaging techniques enable the visualization of serotonin transporter (SERT) occupancy as a measure of the proportion of SERT blocked by an...
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Translocator protein (18 kDa) positron emission tomography imaging as a biomarker of neuroinflammation in epilepsy
Increasing evidence indicate that neuroinflammation triggered by glial cells plays a significant role in epileptogenesis. To this effect, the...
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Validation of dynamic [18F]FE-PE2I PET for estimation of relative regional cerebral blood flow: a comparison with [15O]H2O PET
BackgroundDopamine transporter (DAT) imaging is used in the diagnostic work-up in suspected parkinsonian syndromes and dementia with Lewy bodies but...
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Assessing the impact of different penalty factors of the Bayesian reconstruction algorithm Q.Clear on in vivo low count kinetic analysis of [11C]PHNO brain PET-MR studies
IntroductionQ.Clear is a Bayesian penalised likelihood (BPL) reconstruction algorithm available on General Electric (GE) Positron Emission Tomography...
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Harmonization of [11C]raclopride brain PET images from the HR+ and HRRT: method development and validation in human subjects
BackgroundThere has been an ongoing need to compare and combine the results of new PET imaging studies conducted with [ 11 C]raclopride with older...
