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A “Prime and Expand” strategy using the multifunctional fusion proteins to generate memory-like NK cells for cell therapy
Adoptive cellular therapy (ACT) using memory-like (ML) natural killer (NK) cells, generated through overnight ex vivo activation with IL-12, IL-15,...
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Assessing the protection elicited by virus-like particles expressing the RSV pre-fusion F and tandem repeated G proteins against RSV rA2 line19F infection in mice
Excessive pulmonary inflammation is the hallmark of respiratory syncytial virus (RSV) infection hindering efficacious RSV vaccine development. Yet,...
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Fusion protein and hemagglutinin of canine distemper virus co-induce apoptosis in canine mammary tumor cells
BackgroundCanine distemper virus (CDV) has been shown to have oncolytic activity against primary canine tumors. Previous studies from this laboratory...
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A novel fusion protein candidate for the serodiagnosis of Mycoplasma agalactiae infection
BackgroundThe aim of current study was to construct, express, purify and immunogenicity evaluate of a novel recombinant fusion protein including...
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Establishment of enzyme-linked immunosorbent assays based on recombinant S1 and its truncated proteins for detection of PEDV IgA antibody
Porcine epidemic diarrhea virus (PEDV) can infect pigs of all ages, especially piglets. PEDV has spread across Asia since the 1980s. The highly...
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A novel recombinant adenovirus expressing apoptin and melittin genes kills hepatocellular carcinoma cells and inhibits the growth of ectopic tumor
HCC is the most common fatal malignancy. Although surgical resection is the primary treatment strategy, most patients are not eligible for resection...
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TurboID screening of ApxI toxin interactants identifies host proteins involved in Actinobacillus pleuropneumoniae-induced apoptosis of immortalized porcine alveolar macrophages
Actinobacillus pleuropneumoniae (APP) is a gram-negative pathogenic bacterium responsible for porcine contagious pleuropneumonia (PCP), which can...
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89Zr-immunoPET-guided selection of a CD33xIL15 fusion protein optimized for antitumor immune cell activation and in vivo tumour retention in acute myeloid leukaemia
PurposeImmune cells are capable of eliminating leukemic cells, as evidenced by outcomes in hematopoietic cell transplantation (HCT). However,...
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Potent anti-tumor immune response and tumor growth inhibition induced by HER2 subdomain fusion protein in a mouse tumor model
PurposeSeveral approaches have so far been employed to establish anti-tumor immunity by targeting HER2 protein. Active immunization with recombinant...
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Evaluation of the efficacy and safety of Escherichia coli-derived recombinant human bone morphogenetic protein-2 in transforaminal lumbar interbody fusion to treat degenerative spinal disease: a protocol of prospective, randomized controlled, assessor-blinded, open-label, multicenter trial
BackgroundRecombinant human bone morphogenetic protein-2 (rhBMP-2) has been widely used as an alternative bone graft in spine fusion surgery....
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Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines
The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has...
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An improved system to generate recombinant canine distemper virus
BackgroundCanine distemper virus (CDV) is a pathogen with the capability of cross-species transmission. It has crossed the species barrier to infect...
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Therapeutic benefits of recombinant alpha1-antitrypsin IgG1 Fc-fusion protein in experimental emphysema
BackgroundAlpha-1 antitrypsin (AAT) is a major serine protease inhibitor. AAT deficiency (AATD) is a genetic disorder characterized by early-onset...
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Recombinant adenovirus expressing vesicular stomatitis virus G proteins induce both humoral and cell-mediated immune responses in mice and goats
BackgroundVesicular stomatitis (VS) is an acute, highly contagious and economically important zoonotic disease caused by the vesicular stomatitis...
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Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein
Respiratory syncytial virus (RSV) is the major cause of bronchiolitis and pneumonia in young children and the elderly. There are currently no...
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Use of live attenuated recombinant Newcastle disease virus carrying avian paramyxovirus 2 HN and F protein genes to enhance immune responses against species A rotavirus VP6 protein
Numerous infectious diseases in cattle lead to reductions in body weight, milk production, and reproductive performance. Cattle are primarily...
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Application of rhBMP in spinal fusion surgery: any correlation of cancer incidence? A systematic review and meta-analysis
PurposeSafety concerns regarding the application of bone morphogenetic proteins (BMPs) have been highlighted in recent years. It is noted that both...
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Could eggshell membrane be an adjuvant for recombinant Hepatitis B vaccine?: A preliminary investigation
BackgroundDespite the invasiveness of the Hepatitis B infection, its vaccines are only formulated with FDA-approved alum-based adjuvants, which...
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Recombinant human endostatin as a potential anti-angiogenic agent: therapeutic perspective and current status
Angiogenesis is the physiological process that results in the formation of new blood vessels develop from pre-existing vasculature and plays a...
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Characterization of translocon proteins in the type III secretion system of Lawsonia intracellularis
Lawsonia intracellularis , the etiologic agent of proliferative enteropathy (PE), is an obligate intracellular Gram-negative bacterium possessing a...
