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From real world data to real world evidence to improve outcomes in neuro-ophthalmology
Real-world data (RWD) can be defined as all data generated during routine clinical care. This includes electronic health records, disease-specific...
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A step-by-step guide to causal study design using real-world data
Due to the need for generalizable and rapidly delivered evidence to inform healthcare decision-making, real-world data have grown increasingly...
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The S-REAL study: Spanish real-world data on unresectable stage III NSCLC patients treated with durvalumab after chemoradiotherapy
ObjectivesThe S-REAL study aimed to assess the effectiveness of durvalumab as consolidation therapy after definitive chemoradiotherapy (CRT) in a...
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Von Real-World-Daten zur Real-World-Evidenz: eine praktische Anleitung
BackgroundReal-world evidence (RWE), the understanding of treatment effectiveness in clinical practice generated from longitudinal patient-level data...
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Polygenic liability for antipsychotic dosage and polypharmacy - a real-world registry and biobank study
Genomic prediction of antipsychotic dose and polypharmacy has been difficult, mainly due to limited access to large cohorts with genetic and drug...
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Real-World Use of Oral Semaglutide in Adults with Type 2 Diabetes in the PIONEER REAL Netherlands Multicentre, Prospective, Observational Study
IntroductionIn this phase 4, multicentre, prospective, non-interventional PIONEER REAL Netherlands study, we assessed clinical outcomes associated...
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Alzheimer’s Disease Linkage to Real-World Evidence (AD-LINE) Study: Linking Claims Data to Phase 3 GRADUATE Study of Gantenerumab
BackgroundLinking data from clinical trials and real-world claims may improve the robustness of trial data and provide information on the health,...
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Daridorexant treatment for chronic insomnia: a real-world retrospective single-center study
IntroductionChronic insomnia disorder (CID) significantly impacts well-being and daily functioning. Daridorexant, a double orexin receptor blocker,...
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Real-World Use of Oral Semaglutide in Adults with Type 2 Diabetes: The PIONEER REAL Switzerland Multicentre, Prospective, Observational Study
IntroductionReal-world data provide insight into how medications perform in clinical practice. The PIONEER REAL Switzerland study aimed to understand...
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Real-world evidence of fremanezumab for treating migraine in Japan: a retrospective study
BackgroundThere have been very few real-world studies reported in the literature solely focusing on fremanezumab in Asia. This study aimed to...
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Outcomes of male patients with HR+/HER2– advanced breast cancer receiving palbociclib in the real-world POLARIS study
PurposeData on treatments for male breast cancer patients are limited owing to rarity and underrepresentation in clinical trials. The real-world...
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Study design of a phase 4, real-world study (COMPOSUR) to evaluate vibegron in patients with overactive bladder
BackgroundOveractive bladder (OAB) is defined as urinary urgency accompanied by frequency and nocturia, with or without urge urinary incontinence...
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Real-world outcomes of mepolizumab for the treatment of severe eosinophilic asthma in Canada: an observational study
BackgroundMepolizumab, the first widely available anti-interleukin 5 biologic, targets eosinophilic inflammation and has been shown in clinical...
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Real-World Evidence on Levetiracetam-Induced Hypokalemia: An Active Comparator Cohort Study
BackgroundLevetiracetam is an anti-seizure medication (ASM) with an established safety profile. However, a potential safety signal of hypokalemia...
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The impact of menopause on antidepressant response: an explorative analysis from a real-world study
This study endeavors to deepen our understanding of the subject matter by exploring, within a real-world sample, the impact of menopausal status on...
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Large-Scale, Multicenter, Prospective Registry Study of Ripretinib in Advanced GIST: A Real-World Study from China
IntroductionTyrosine-kinase inhibitors (TKIs) have become the standard treatment for patients with advanced gastrointestinal stromal tumor (GIST);...
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Real-world effectiveness and satisfaction with intravenous eptinezumab treatment in patients with chronic migraine: REVIEW, an observational, multi-site, US-based study
BackgroundDespite recent advancements in migraine treatment, some patients continue to endure significant disease burden. Due to the controlled...
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Panretinal photocoagulation plus intravitreal conbercept for diabetic retinopathy in real world: a retrospective study
BackgroundTo evaluate outcomes of panretinal photocoagulation (PRP) plus intravitreal conbercept (IVC) for diabetic retinopathy (DR) in real world...
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Real-World Study of Adjuvant Biosimilar Trastuzumab-dkst for HER2-Positive Breast Cancer Treatment in a Brazilian Population
IntroductionBiological monoclonal antibodies play a pivotal role in cancer treatment, with biosimilars significantly enhancing their accessibility....
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Real-world experience with brolucizumab in neovascular age-related macular degeneration over 2 years: the REBA extension study
BackgroundTo determine long-term efficacy and safety of intravitreal brolucizumab therapy for neovascular age-related macular degeneration (nAMD) in...
