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From real world data to real world evidence to improve outcomes in neuro-ophthalmology
Real-world data (RWD) can be defined as all data generated during routine clinical care. This includes electronic health records, disease-specific...
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Von Real-World-Daten zur Real-World-Evidenz: eine praktische Anleitung
BackgroundReal-world evidence (RWE), the understanding of treatment effectiveness in clinical practice generated from longitudinal patient-level data...
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Real-world-Ergebnisse von glaukomchirurgischen Verfahren beim Offenwinkelglaukom
This article provides an overview of real-world outcomes in glaucoma surgical procedures. While randomized clinical trials provide valuable insights,...
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Die Anwendung von Real-world-Evidenz in Entscheidungsprozessen der Arzneimittelregulation
Drug regulation is a system to support and protect public health. Drugs with market access must be effective, safe and of high quality. Therefore,...
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Die Auswirkungen von Primärdatenqualität und -interoperabilität auf Analysen von Real-World-Daten
Real-world data is increasingly becoming the focus of healthcare research in the context of digitization. The timely availability of large amounts of...
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ATRAcTR (Authentic Transparent Relevant Accurate Track-Record): a screening tool to assess the potential for real-world data sources to support creation of credible real-world evidence for regulatory decision-making
Adoption and use of real-world data (RWD) for decision-making has been complicated by concerns regarding whether RWD was fit-for-purpose or was of...
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Real-world experience with filgotinib for rheumatoid arthritis in Germany
BackgroundReal-world data for filgotinib, a Janus kinase (JAK)1 inhibitor, are limited in patients with rheumatoid arthritis (RA).
Objectives ...
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Real-world analysis of teclistamab in 123 RRMM patients from Germany
Teclistamab, a B-cell maturation antigen (BCMA) × CD3 directed bispecific antibody, has shown high response rates and durable remissions in the...
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Real-world Management of CML: Outcomes and Treatment Patterns
Purpose of ReviewChronic myeloid leukemia (CML) is a disease that previously signified a poor prognosis, but treatment options and outcomes have...
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The S-REAL study: Spanish real-world data on unresectable stage III NSCLC patients treated with durvalumab after chemoradiotherapy
ObjectivesThe S-REAL study aimed to assess the effectiveness of durvalumab as consolidation therapy after definitive chemoradiotherapy (CRT) in a...
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Datenschutzgerechte Wege zur Nutzung von Real World Data
BackgroundThe secondary use of existing real world data is seen as a promising method of medical research that complements the conduct of closely...
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Development of a real-world database for asthma and COPD: The SingHealth-Duke-NUS-GSK COPD and Asthma Real-World Evidence (SDG-CARE) collaboration
PurposeThe SingHealth-Duke-GlaxoSmithKline COPD and Asthma Real-world Evidence (SDG-CARE) collaboration was formed to accelerate the use of...
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A step-by-step guide to causal study design using real-world data
Due to the need for generalizable and rapidly delivered evidence to inform healthcare decision-making, real-world data have grown increasingly...
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Observing the Clinical Course of Duchenne Muscular Dystrophy in Medicaid Real-World Healthcare Data
IntroductionDuchenne muscular dystrophy (DMD) is a rare, severe progressive neuromuscular disease. Health insurance claims allow characterization of...
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Impact of Immunotherapy on Real-World Survival Outcomes in Metastatic Renal Cell Carcinoma
BackgroundTreatment options for metastatic renal cell carcinoma (mRCC) are rapidly expanding, and immunotherapy using checkpoint inhibitors is a...
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Real-World Use of Oral Semaglutide in Adults with Type 2 Diabetes in the PIONEER REAL Netherlands Multicentre, Prospective, Observational Study
IntroductionIn this phase 4, multicentre, prospective, non-interventional PIONEER REAL Netherlands study, we assessed clinical outcomes associated...
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Development and validation of thromboembolism diagnostic algorithms in children with cancer from real-world data
ObjectiveTo evaluate the accuracy of diagnostic algorithms developed using the International Classification of Diseases (ICD-9-CM and ICD-10-CA)...
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Real World Evidence: methodological issues and opportunities from the European Health Data Space
The current Evidence-Based-Medicine (EBM) approach is generally based on data coming from Randomized Clinical Trials or and, epidemiological...
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Polygenic liability for antipsychotic dosage and polypharmacy - a real-world registry and biobank study
Genomic prediction of antipsychotic dose and polypharmacy has been difficult, mainly due to limited access to large cohorts with genetic and drug...
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Evaluating and improving real-world evidence with Targeted Learning
BackgroundThe Targeted Learning roadmap provides a systematic guide for generating and evaluating real-world evidence (RWE). From a regulatory...
