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Molecular mechanism of bovine Gasdermin D-mediated pyroptosis
Pyroptosis is a form of programmed cell death characterized by cell swelling, pore formation in the plasma membrane, lysis, and releases of...
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The roles of pyroptosis in genitourinary diseases
Pyroptosis, a form of programmed cell death distinct from apoptosis and necrosis, is thought to be closely associated with the pathogenesis of...
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Research Progress on Pyroptosis in Hematological Malignancies
Pyroptosis is a kind of programmed cell death dependent on the caspase pathway that is different from apoptosis and necrosis. Recent studies have...
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Gasdermins and pyroptosis in the kidney
Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-forming gasdermin family of proteins. Pyroptosis was...
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Pyroptosis in cancer treatment and prevention: the role of natural products and their bioactive compounds
Targeting programmed cell death (PCD) has been emerging as a promising therapeutic strategy in cancer. Pyroptosis, as a type of PCDs, leads to the...
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Pyroptosis of Vascular Smooth Muscle Cells as a Potential New Target for Preventing Vascular Diseases
Vascular remodeling is the adaptive response of the vessel wall to physiological and pathophysiological changes, closely linked to vascular diseases....
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Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke
BackgroundPyroptosis plays an important role in the pathological process of ischemic stroke (IS). However, the exact mechanism of pyroptosis remains...
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Quercetin inhibits caspase-1-dependent macrophage pyroptosis in experimental folic acid nephropathy
BackgroundThe role of pyroptosis in kidney disease is limited and incomplete. Quercetin, a flavonoid compound present in a variety of fruits,...
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The role of pyroptosis and gasdermin family in tumor progression and immune microenvironment
Pyroptosis, an inflammatory programmed cell death, distinguishes itself from apoptosis and necroptosis and has drawn increasing attention. Recent...
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Endoplasmic reticulum aminopeptidase 2 regulates CD4+ T cells pyroptosis in rheumatoid arthritis
ObjectiveRheumatoid arthritis (RA) is a chronic, progressive autoimmune disease with a complex pathogenesis that has not yet been fully elucidated,...
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Pyroptosis in urinary malignancies: a literature review
Urinary neoplasms refer to malignant tumours occurring in any part of the urinary system, including the kidney, renal pelvis, ureter, bladder,...
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Penehyclidine hydrochloride alleviates lung ischemia-reperfusion injury by inhibiting pyroptosis
ObjectiveThe aim of this research was to examine how penehyclidine hydrochloride (PHC) impacts the occurrence of pyroptosis in lung tissue cells...
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16S rRNA seq-identified Corynebacterium promotes pyroptosis to aggravate diabetic foot ulcer
BackgroundDiabetic foot ulcer (DFU) is one of the main chronic complications caused by diabetes, leading to amputation in severe cases. Bacterial...
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Pyroptosis -related potential diagnostic biomarkers in steroid-induced osteonecrosis of the femoral head
PurposeSteroid-induced necrosis of the femoral head (SONFH) is a refractory orthopedic hip disease occurring in young and middle-aged people, with...
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Multiomics characterization of pyroptosis in the tumor microenvironment and therapeutic relevance in metastatic melanoma
BackgroundPyroptosis, mediated by gasdermins with the release of multiple inflammatory cytokines, has emerged as playing an important role in...
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Growth differentiation factor 11 regulates high glucose-induced cardiomyocyte pyroptosis and diabetic cardiomyopathy by inhibiting inflammasome activation
BackgroundDiabetic cardiomyopathy (DCM) is a crucial complication of long-term chronic diabetes that can lead to myocardial hypertrophy, myocardial...
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Bhlhe40 deficiency attenuates LPS-induced acute lung injury through preventing macrophage pyroptosis
BackgroundAcute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) as common life-threatening lung diseases with...
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Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma
While Stimulator-of-interferon genes (STING) is an innate immune adapter cruicial for sensing cytosolic DNA and modulating immune microenvironment,...
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Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats
Melatonin improves chronic stress-induced hippocampal damage and depression-like behaviors, but the mechanism needs further study. This study was to...
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Bibliometric and visual analysis of diabetes mellitus and pyroptosis from 2011 to 2022
ObjectiveTo visualize and analyze the published literature on diabetes mellitus and pyroptosis based on a bibliometric approach, so as to provide a...
