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Serum proteome analysis identifies a potential biomarker for axial psoriatic arthritis
BackgroundTo identify potential serum biomarkers for differentiating between axial psoriatic arthritis (axPsA) and peripheral psoriatic arthritis...
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Metataxonomic analysis and host proteome response in dairy cows with high and low somatic cell count: a quarter level investigation
Host response to invasive microbes in the bovine udder has an important role on the animal health and is essential to the dairy industry to ensure...
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Proteome analysis of monocytes implicates altered mitochondrial biology in adults reporting adverse childhood experiences
The experience of adversity in childhood has been associated with poor health outcomes in adulthood. In search of the biological mechanisms...
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Novel Drug Targets for Atrial Fibrillation Identified Through Mendelian Randomization Analysis of the Blood Proteome
PurposeNovel, effective, and safe preventive therapy targets for AF are still needed. Circulating proteins with causal genetic evidence are promising...
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Assessing the effects of antipsychotic medications on schizophrenia functional analysis: a postmortem proteome study
Antipsychotic drugs (APDs) are effective in treating positive symptoms of schizophrenia (SCZ). However, they have a substantial impact on postmortem...
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Identifying causal genes for migraine by integrating the proteome and transcriptome
BackgroundWhile previous genome-wide association studies (GWAS) have identified multiple risk variants for migraine, there is a lack of evidence...
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Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disorders
Psychiatric disorders are highly heritable yet polygenic, potentially involving hundreds of risk genes. Genome-wide association studies have...
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Starch treatment improves the salivary proteome for subject identification purposes
Identification of subjects, including perpetrators, is one of the most crucial goals of forensic science. Saliva is among the most common biological...
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Quantitative urinary proteome analysis reveals potential biomarkers for disease activity of Behcet’s disease uveitis
PurposeBehçet’s disease-associated uveitis (BDU) is a severe, recurrent inflammatory condition affecting the eye and is part of a systemic vasculitis...
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Proteome-wide association studies have predicted that the protein abundance of LSM6, GMPPB, ICA1L, and CISD2 is associated with attention-deficit/hyperactivity disorder
Identification of changes in protein abundance for attention-deficit/hyperactivity disorder (ADHD) is important for potential disease mechanisms and...
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Splenic proteome profiling in response to Marek’s disease virus strain GX0101 infection
Marek’s disease virus (MDV) strain GX0101 was the first reported field strain of recombinant gallid herpesvirus type 2 (GaHV-2). However, the splenic...
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Proteome analysis of urinary biomarkers in a cigarette smoke-induced COPD rat model
BackgroundChronic obstructive pulmonary disease (COPD) is a chronic inflammatory airway disease caused by inhalation of cigarette smoke (CS) and...
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Tissue proteome analysis revealed an association between cancer, immune system response, and the idiopathic granulomatous mastitis
Idiopathic Granulomatous Mastitis (IGM) is a disease that clinically mimics breast cancers with symptoms of pain, edema, erythema, nipple discharge,...
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Intraglandular mesenchymal stem cell treatment induces changes in the salivary proteome of irradiated patients
BackgroundHyposalivation and xerostomia (dry mouth), are the leading site-effects to treatment of head and neck cancer. Currently, there are no...
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Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapse
BackgroundMitral valve prolapse (MVP) is a common heart disorder characterized by an excessive production of proteoglycans and extracellular matrix...
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Circulating Proteome Analysis Identifies Reduced Inflammation After Initiation of Hemodynamic Support with Either Veno-Arterial Extracorporeal Membrane Oxygenation or Impella in Patients with Cardiogenic Shock
In-hospital mortality associated with cardiogenic shock (CS) remains high despite the use of percutaneous assist devices. We sought to determine...
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Causal inference of the effect of blood proteome on the risk of head and neck cancer: two-sample Mendelian randomization
Early diagnosis of head and neck cancer can improve therapeutic outcomes but remains a challenge. The blood proteome can comprise a key source of...
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Is tear proteome profile a predictor of develo** uveitis in ANA-positive patients with oligoarticular juvenile idiopathic arthritis?
PurposeAlthough less than one-third of anti-nuclear antibody (ANA) positive patients with oJIA develop uveitis, ANA positivity is still the most...
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Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children
IntroductionAlthough different phenotypes of lung disease after preterm birth have recently been described, the underlying mechanisms associated with...
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Combined transcriptome and proteome analysis reveals MSN and ARFIP2 as biomarkers for trastuzumab resistance of breast cancer
PurposeHER2-positive breast cancer (BC) accounts for 20–30% of all BC subtypes and is linked to poor prognosis. Trastuzumab (Tz), a humanized...
