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Progression to corticobasal syndrome: a longitudinal study of patients with nonfluent primary progressive aphasia and primary progressive apraxia of speech
Background and objectivesNonfluent variant primary progressive aphasia (nfvPPA) and primary progressive apraxia of speech (PPAOS) can be precursors...
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Primary progressive aphasia: six questions in search of an answer
Here, we review recent progress in the diagnosis and management of primary progressive aphasia—the language-led dementias. We pose six key unanswered...
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Interobserver assessment of metabolic patterns in progressive primary aphasia through the application of [18F]-Fluorodeoxiglucose PET/CT
PurposeOur primary objective was to evaluate interobserver variability in [18 F]-FDG PET/CT image interpretation in Primary Progressive Aphasia...
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Treatment of primary progressive aphasia by repetitive transcranial magnetic stimulation: a randomized, double-blind, placebo-controlled study
To evaluate the efficacy of high-frequency repetitive transcranial magnetic stimulation (rTMS) in patients with primary progressive aphasia (PPA). In...
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Longitudinal study of primary progressive aphasia in a patient with pathologically diagnosed Alzheimer’s disease: a case report
BackgroundAlzheimer’s disease is a neurodegenerative disease involving the deposition of pathologic amyloid-β and tau protein in the cerebral cortex....
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The natural history of primary progressive aphasia: beyond aphasia
IntroductionPrimary progressive aphasia (PPA) is divided into three prototypical subtypes that are all characterized by their single core symptom of...
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Results from a randomised controlled pilot study of the Better Conversations with Primary Progressive Aphasia (BCPPA) communication partner training program for people with PPA and their communication partners
BackgroundThere has been a growing focus on functional communication interventions for primary progressive aphasia (PPA). These interventions aim to...
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Primary Progressive Aphasia: Toward a Pathophysiological Synthesis
Purpose of ReviewThe term primary progressive aphasia (PPA) refers to a diverse group of dementias that present with prominent and early problems...
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Hereditary diffuse leukoencephalopathy with spheroids mimicking primary progressive aphasia: report of a Greek case
IntroductionHereditary diffuse leukoencephalopathy with spheroids (HDLS) is an adult onset leukodystrophy, causally related to mutations in the...
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Progressive Supranuclear Palsy Diagnosis and Treatment
Purpose of reviewThis review describes the current approaches to the diagnosis and management of progressive supranuclear palsy (PSP)
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An Update on Apraxia of Speech
Purpose of ReviewApraxia of speech (AOS) is a motor speech disorder that has long been recognized to occur secondary to acute neurologic insults and,...
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Diagnosis and Management of Progressive Corticobasal Syndrome
Purpose of reviewThe purpose of this review is to discuss the clinical, radiological, and neuropathological heterogeneity of corticobasal syndrome...
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Evaluation of rTMS in patients with poststroke aphasia: a systematic review and focused meta-analysis
PurposeAphasia—acquired loss of the ability to understand or express language—is a common and debilitating neurological consequence of stroke....
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Longitudinal volumetric changes in amygdala subregions in frontotemporal dementia
Amygdala atrophy has been found in frontotemporal dementia (FTD), yet the specific changes of its subregions across different FTD phenotypes remain...
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Hereditary primary lateral sclerosis and progressive nonfluent aphasia
ObjectiveTo report a kindred with an association between hereditary primary lateral sclerosis (PLS) and progressive nonfluent aphasia.
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The efficacy of acoustic-based articulatory phenoty** for characterizing and classifying four divergent neurodegenerative diseases using sequential motion rates
Despite the impacts of neurodegeneration on speech function, little is known about how to comprehensively characterize the resulting speech...
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Crossed aphasia confirmed by fMRI in a case with nonfluent variant of primary progressive aphasia carrying a GRN mutation
ObjectivesTo characterize patterns of language lateralization in a right-handed woman with nonfluent/agrammatic primary progressive aphasia (nfvPPA)...
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The Landscape Montage Technique for diagnosing frontotemporal dementia starting as primary progressive aphasia: a case report
BackgroundThe Landscape Montage Technique was originally developed by Hisao Nakai, a Japanese psychiatrist, to pursue the possibility and application...
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Addition of the FTD Module to the Neuropsychiatric Inventory improves classification of frontotemporal dementia spectrum disorders
Most neuropsychiatric symptoms (NPS) common in frontotemporal dementia (FTD) are currently not part of the Neuropsychiatric Inventory (NPI). We...
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Progressive apraxia of speech: delays to diagnosis and rates of alternative diagnoses
BackgroundProgressive apraxia of speech (PAOS) is a neurodegenerative disorder of speech programming distinct from aphasia and dysarthria, most...