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Research Progress on Histone Deacetylases Regulating Programmed Cell Death in Atherosclerosis
AbstractHistone deacetylases (HDACs) are epigenetic modifying enzyme that is closely related to chromatin structure and gene transcription, and...
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Re-immunotherapy with nivolumab plus ipilimumab in advanced non-small cell lung cancer patients previously treated with anti-programmed death-1 and/or anti-programmed death ligand-1 antibodies
BackgroundThe role of re-immunotherapy in advanced non-small cell lung cancer (NSCLC) remains unclear. No studies have evaluated the re-immunotherapy...
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Programmed axon death: a promising target for treating retinal and optic nerve disorders
Programmed axon death is a druggable pathway of axon degeneration that has garnered considerable interest from pharmaceutical companies as a...
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A novel defined programmed cell death related gene signature for predicting the prognosis of serous ovarian cancer
PurposeThis study aims to explore the contribution of differentially expressed programmed cell death genes (DEPCDGs) to the heterogeneity of serous...
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Effect of doramectin on programmed cell death pathway in glioma cells
PurposeDoramectin (DRM) is a kind of avermectin drugs, and it has been shown that DRM has anti-cancer effects. However, the molecular mechanism of...
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Decoding the genetic links between serum lipidomic profile, amino acid biomarkers, and programmed cell death protein-1/programmed cell death-ligand-1
BackgroundDisruptions in lipid metabolism and amino acids have been increasingly linked to resistance to immunotherapy. However, the underlying...
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Programmed Death of Microglia in Alzheimer’s Disease: Autophagy, Ferroptosis, and Pyroptosis
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, amyloid-β (Aβ) plaques and the formation of...
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Oxidative Stress-Mediated Programmed Cell Death: a Potential Therapy Target for Atherosclerosis
Nowadays, as a type of orderly and active death determined by genes, programmed cell death (PCD), including apoptosis, pyroptosis, ferroptosis, and...
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Expression of Programmed Death Ligand 1 [PD-L1] and Mismatch Repair Status in Squamous Cell Carcinomas of Cervix
Background and ObjectivesTo assess mismatch repair (MMR) status and programmed death-ligand 1 (PD-L1) expression in squamous cell carcinomas of the...
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Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets
Atherosclerosis is a progressive inflammatory disorder of the arterial vessel wall characterized by substantial infiltration of macrophages, which...
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Molecular subtypes of lung adenocarcinoma patients for prognosis and therapeutic response prediction with machine learning on 13 programmed cell death patterns
BackgroundLung adenocarcinoma (LUAD) seriously threatens people’s health worldwide. Programmed cell death (PCD) plays a critical role in regulating...
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Identification and validation of an immune-derived multiple programmed cell death index for predicting clinical outcomes, molecular subty**, and drug sensitivity in lung adenocarcinoma
ObjectivesComprehensive cross-interaction of multiple programmed cell death (PCD) patterns in the patients with lung adenocarcinoma (LUAD) have not...
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Exploration of programmed cell death-associated characteristics and immune infiltration in neonatal sepsis: new insights from bioinformatics analysis and machine learning
BackgroundNeonatal sepsis, a perilous medical situation, is typified by the malfunction of organs and serves as the primary reason for neonatal...
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Knowledge map** of programmed cell death in osteonecrosis of femoral head: a bibliometric analysis (2000–2022)
BackgroundOsteonecrosis of the femoral head (ONFH) is a common, refractory and disabling disease of orthopedic department, which is one of the common...
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The worsening impact of programmed cell death ligand 1 in ovarian clear cell carcinomas
PurposeTo investigate the clinical significance of programmed cell death ligand 1 (PD-L1) expression in ovarian clear cell carcinoma (CCC).
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