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Identification of a novel perifornical-hypothalamic-area-projecting serotonergic system that inhibits innate panic and conditioned fear responses
The serotonin (5-HT) system is heavily implicated in the regulation of anxiety and trauma-related disorders such as panic disorder and post-traumatic...
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Evolution of flash visual evoked potentials to monitor visual pathway integrity during tumor resection: illustrative cases and literature review
Flash visual evoked potentials (fVEPs) provide a means to interrogate visual system functioning intraoperatively during tumor resection in which the...
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VTA glutamatergic projections to the nucleus accumbens suppress psychostimulant-seeking behavior
Converging evidence indicates that both dopamine and glutamate neurotransmission within the nucleus accumbens (NAc) play a role in psychostimulant...
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Optogenetic recruitment of hypothalamic corticotrophin-releasing-hormone (CRH) neurons reduces motivational drive
Impaired motivational drive is a key feature of depression. Chronic stress is a known antecedent to the development of depression in humans and...
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Early impairment of cortical circuit plasticity and connectivity in the 5XFAD Alzheimer’s disease mouse model
Genetic risk factors for neurodegenerative disorders, such as Alzheimer’s disease (AD), are expressed throughout the life span. How these risk...
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Optogenetic stimulation of mouse Hoxb8 microglia in specific regions of the brain induces anxiety, grooming, or both
Previously, we have shown that either disruption of the Hoxb8 gene or ablation of a microglial subpopulation, Hoxb8 microglia, results in mice...
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Neuronal and astrocytic CB1R signaling differentially modulates goal-directed behavior and working memory by distinct temporal mechanisms
Several cognitive processes, including instrumental behavior and working memory, are controlled by endocannabinoids acting on cannabinoid receptor 1...
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Ventral subiculum promotes wakefulness through several pathways in male mice
The ventral subiculum (vSUB), the major output structure of the hippocampal formation, regulates motivation, stress integration, and anxiety-like...
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Formation and fate of an engram in the lateral amygdala supporting a rewarding memory in mice
Memories allow past experiences to guide future decision making and behavior. Sparse ensembles of neurons, known as engrams, are thought to store...
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Stress integration by an ascending adrenergic-melanocortin circuit
Stress is thought to be an important contributing factor for eating disorders; however, neural substrates underlying the complex relationship between...
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Clinical course of two siblings with potassium voltage-gated channel modifier subfamily V member 2 (KCNV2)-associated retinopathy
BackgroundKCNV2 -associated retinopathy causes a phenotype reported as “cone dystrophy with nyctalopia and supernormal rod responses (CDSRR; OMIM#...
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Optogenetic cortical spreading depolarization induces headache-related behaviour and neuroinflammatory responses some prolonged in familial hemiplegic migraine type 1 mice
BackgroundCortical spreading depolarization (CSD), the neurophysiological correlate of the migraine aura, can activate trigeminal pain pathways, but...
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Could violet-blue lights increase the bacteria resistance against ultraviolet radiation mediated by photolyases?
Studies have demonstrated bacterial inactivation by radiations at wavelengths between 400 and 500 nm emitted by low-power light sources. The...
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Prefrontal cortical circuits in anxiety and fear: an overview
Pathological anxiety is among the most difficult neuropsychiatric diseases to treat pharmacologically, and it represents a major societal problem....
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A triple-network organization for the mouse brain
The triple-network model of psychopathology is a framework to explain the functional and structural neuroimaging phenotypes of psychiatric and...
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Photostimulation of osteogenic differentiation on silk scaffolds by plasma arc light source
Low-level laser therapy (LLLT) has been used for more than 30 years to heal wounds. In recent years, LLLT or photostimulation has been indicated as...
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Effect of photobiomodulation adjunct to periodontal therapy on individuals with type 2 diabetes mellitus regarding periodontal clinical parameters: a systematic review and meta-analysis
The purpose of this study is to evaluate the scientific evidence on the impact of photobiomodulation adjunct to non-surgical periodontal treatment on...
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Dynamic tripartite construct of interregional engram circuits underlies forgetting of extinction memory
Fear extinction allows for adaptive control of learned fear responses but often fails, resulting in a renewal or spontaneous recovery of the...
