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Pharmacokinetics: Basics to Applications
This textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on...
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Plasma Pharmacokinetics of N-Acetylgalactosamine-Conjugated Small-Interfering Ribonucleic Acids (GalNAc-Conjugated siRNAs)
Small-interfering ribonucleic acids (siRNAs) with N-acetylgalactosamine (GalNAc) conjugation for improved liver uptake represent an emerging class of...
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Significant impact of time-of-day variation on metformin pharmacokinetics
Aims/hypothesisThe objective was to investigate if metformin pharmacokinetics is modulated by time-of-day in humans using empirical and mechanistic...
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Factors Influencing Unfractionated Heparin Pharmacokinetics and Pharmacodynamics During a Cardiopulmonary Bypass
BackgroundUnfractionated heparin (UFH) is commonly used during cardiac surgery with a cardiopulmonary bypass to prevent blood clotting. However,...
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Clinical Pharmacokinetics and Pharmacodynamics of Naloxone
Naloxone is a World Health Organization (WHO)-listed essential medicine and is the first choice for treating the respiratory depression of opioids,...
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The Effects of Bariatric Surgery on Pharmacokinetics of Drugs: a Review of Current Evidence
Purpose of ReviewObesity constitutes a major public health concern and has been recognized as an epidemic. To date, bariatric surgery remains the...
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Clinical Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Anifrolumab
The type I interferon (IFN) signaling pathway is implicated in the pathogenesis of systemic lupus erythematosus (SLE). Anifrolumab is a monoclonal...
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Pharmacokinetics and Pharmacodynamics of Ruxolitinib: A Review
Background and ObjectiveRuxolitinib is a tyrosine kinase inhibitor targeting the Janus kinase (JAK) and signal transducer and activator of...
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Pharmacokinetics of Henagliflozin in Dialysis Patients with Diabetes
AimThis study aimed to assess the pharmacokinetics of henagliflozin in dialysis patients with diabetes.
MethodsIn this prospective, randomized,...
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Pharmacokinetics of Oral Vitamin D in Children with Obesity and Asthma
Background and ObjectiveVitamin D insufficiency is common in several pediatric diseases including obesity and asthma. Little data exist describing...
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Population Pharmacokinetics of Total and Unbound Isavuconazole in Critically Ill Patients: Implications for Adaptive Dosing Strategies
Background and ObjectivesIsavuconazole is a broad-spectrum antifungal agent for the management of invasive fungal disease. Optimised drug exposure is...
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Population Pharmacokinetics of Intravenous Lidocaine in Adults: A Systematic Review
BackgroundThe establishment of optimal dosing regimens for intravenous (IV) lidocaine in the perioperative setting, aiming to balance effective pain...
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Upadacitinib Population Pharmacokinetics and Exposure-Response Relationships in Ulcerative Colitis Patients
Background and ObjectiveUpadacitinib, an oral selective and reversible Janus kinase (JAK) inhibitor, showed favorable efficacy and safety in patients...
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Pharmacokinetics, Safety, and Tolerability of Single-Dose Orally Administered Venglustat in Healthy Chinese Volunteers
Background and ObjectiveDeficiencies of enzymes acting downstream of glucosylceramide synthase (GCS) can cause severe substrate accumulation....
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A Phase 1 Study of Ensitrelvir Fumaric Acid Tablets Evaluating the Safety, Pharmacokinetics and Food Effect in Healthy Adult Populations
BackgroundA reported clinical pharmacokinetics and safety study of suspension formulation of ensitrelvir, a therapeutic agent used in severe acute...
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Mechanism of action, resistance, interaction, pharmacokinetics, pharmacodynamics, and safety of fostemsavir
The Food and Drug Administration (FDA) has licensed many antiretroviral medications to treat human immunodeficiency virus type 1 (HIV-1), however,...
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Impact of loperamide on the pharmacokinetics and tissue disposition of ritonavir-boosted oral docetaxel therapy; a preclinical assessment
PurposeAn oral docetaxel formulation boosted by the Cytochrome P450 (CYP) 3 A inhibitor ritonavir, ModraDoc006/r, is currently under clinical...
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Safety, Tolerability, and Pharmacokinetics of Oral BI 1358894 in Healthy Japanese Male Volunteers
Background and ObjectivesBI 1358894, a novel small-molecule inhibitor of transient receptor potential canonical ion channels, is under development...
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Pharmacokinetics in Critically Ill Children with Acute Kidney Injury
Acute kidney injury (AKI) is a commonly encountered comorbidity in critically ill children. The coexistence of AKI disturbs drug pharmacokinetics and...
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Population pharmacokinetics of oxcarbazepine active metabolite in Chinese children with epilepsy
Oxcarbazepine (OXC) is an antiepileptic drug whose efficacy is largely attributed to its monohydroxy derivative metabolite (MHD). Nevertheless, there...
