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Pharmacodynamic Drug-Drug Interactions and Bleeding Outcomes in Patients with Atrial Fibrillation Using Non-Vitamin K Antagonist Oral Anticoagulants: a Nationwide Cohort Study
PurposePharmacodynamic drug-drug interactions (PD DDIs) may influence the safety of non-vitamin K antagonist oral anticoagulants (NOACs), but the...
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Clinical Pharmacokinetic and Pharmacodynamic Profile of Vericiguat
Vericiguat is an oral soluble guanylate cyclase stimulator and enhances the cyclic guanosine monophosphate pathway independently of nitric oxide as...
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Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone
(R,S)-methadone ((R,S)-MTD) is a µ-opioid receptor (MOR) agonist comprised of (R)-MTD and (S)-MTD enantiomers. (S)-MTD is being developed as an...
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Pharmacokinetic and pharmacodynamic considerations for antifungal therapy optimisation in the treatment of intra-abdominal candidiasis
Intra-abdominal candidiasis (IAC) is one of the most common of invasive candidiasis observed in critically ill patients. It is associated with high...
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Pharmacokinetics and Pharmacodynamic of Alpelisib
Advanced breast cancers are frequently hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative. Some of them...
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Antiseizure Medication Interactions A Clinical Guide
This significantly revised fourth edition provides a practically orientated guide to interactions associated with antiseizure medications. It...
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Interactions between natural products and cancer treatments: underlying mechanisms and clinical importance
Natural products, also referred to as dietary supplements, complementary and alternative medicines, and health or food supplements are widely used by...
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Quantitative Prediction of Adverse Event Probability Due to Pharmacokinetic Interactions
IntroductionIatrogeny due to drug–drug interactions is insufficiently documented, due to the high number of possible combinations.
Objective ...
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Pharmacodynamic Drug–Drug interactions of QT-prolonging drugs in hospitalized psychiatric patients
At least 170 approved drugs are linked to QT prolongation, which can lead to serious adverse drug reactions (ADRs), such as Torsade de Pointes (TdP)....
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A Phase I, Open-Label, Sequential, Single-Dose Clinical Trial to Evaluate the Pharmacokinetic, Pharmacodynamic, and Safety of IVL3001, a Finasteride-Based Novel Long-Acting Injection for Androgenetic Alopecia
IntroductionHair loss is driven by multiple factors, including genetics. Androgenetic alopecia (AGA) is a condition in which treatments necessitate...
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Potentially Harmful Drug–Drug Interactions and Their Associated Factors Among Hospitalized Cardiac Patients: A Cross-Sectional Study
BackgroundCardiovascular diseases are responsible for a significant proportion of mortalities worldwide. Elderly patients are the most affected by...
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Pharmacodynamic effects of the PARP inhibitor talazoparib (MDV3800, BMN 673) in patients with BRCA-mutated advanced solid tumors
PurposeTalazoparib is an inhibitor of the poly (ADP-ribose) polymerase (PARP) family of enzymes and is FDA-approved for patients with (suspected)...
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Mechanistic Pharmacokinetic/Pharmacodynamic Modeling in Support of a Patient-Convenient, Longer Dosing Interval for Carfilzomib, a Covalent Inhibitor of the Proteasome
BackgroundCarfilzomib is an irreversible second-generation proteasome inhibitor that has a short elimination half-life but much longer...
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Pharmacokinetics and pharmacodynamics of drug‒drug interactions in hospitalized older adults treated with direct oral anticoagulants
PurposePolypharmacy is a frequent situation in older adults that increases the risk of drug-drug interactions (DDIs), both pharmacokinetic (PK) and...
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Interactions of Antiretroviral Drugs with Food, Beverages, Dietary Supplements, and Alcohol: A Systematic Review and Meta-analyses
Multiple factors may affect combined antiretroviral therapy (cART). We investigated the impact of food, beverages, dietary supplements, and alcohol...
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Pressure response to fluid challenge administration in hypotensive surgical patients: a post-hoc pharmacodynamic analysis of five datasets
In this study we evaluated the effect of fluid challenge (FC) administration in elective surgical patients with low or normal blood pressure....
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Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone
BackgroundThe prevalence and therapeutic effects of the use of herbal remedies for chronic liver diseases make the combined administration of herbal...
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Factors that Impact the Pharmacokinetic and Pharmacodynamic Effects of Cannabis: a Review of Human Laboratory Studies
Purpose of ReviewWith cannabis legalization expanding throughout the world, an unprecedented number of people now have access to legal cannabis. This...
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Pharmacokinetic drug interactions of oral anticancer drugs
Over the past 20 years, oral anticancer drugs have increased in importance for the treatment of solid tumors and hematological diseases....
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Drug–drug interactions with direct oral anticoagulants: development of a consensus list for ambulatory care
BackgroundDirect oral anticoagulants (DOACs) can be involved in clinical relevant drug–drug interactions (DDIs) which may compromise safe and...