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Pediatric systemic lupus erythematosus: phagocytic defect and oxidase activity of neutrophils
BackgroundThere are limited data on neutrophil function in pediatric-onset systemic lupus erythematosus (pSLE) patients. This study aimed to evaluate...
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Minocycline Attenuates Microglia/Macrophage Phagocytic Activity and Inhibits SAH-Induced Neuronal Cell Death and Inflammation
BackgroundNeuroprotective treatment strategies aiming at interfering with either inflammation or cell death indicate the importance of these...
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The phagocytic role of macrophage following myocardial infarction
Myocardial infarction (MI) is one of the cardiovascular diseases with high morbidity and mortality. MI causes large amounts of apoptotic and necrotic...
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Beta-2 adrenergic receptor agonism alters astrocyte phagocytic activity and has potential applications to psychiatric disease
Schizophrenia is a debilitating condition necessitating more efficacious therapies. Previous studies suggested that schizophrenia development is...
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Identification of sulfur metabolism-related gene signature in osteoarthritis and TM9SF2’s sustenance effect on M2 macrophages' phagocytic activity
BackgroundOsteoarthritis (OA) is a chronic and low-grade inflammatory disease associated with metabolism disorder and multiple cell death types in...
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Phagocytic cell death leads to enhanced release of pro-inflammatory S100A12 in familial Mediterranean fever
BackgroundFamilial Mediterranean fever (FMF) is a prototypical autoinflammatory syndrome associated with phagocytic cell activation. Pyrin mutations...
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Disease activity is associated with changes in the innate immune function in patients with systemic lupus erythematosus
ObjectiveTo address the relationship between systemic lupus erythematosus (SLE) disease activity and the functional parameters of the innate immunity.
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Laboratory Diagnostics of Ovarian Cancer among the Elderly Based on the Parameters of Immunoglobulins and Phagocytic Activity of Blood
AbstractNew diagnostic methods are being sought for ovarian cancer due to its higher prevalence, which is the result of an increase in the share of...
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Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model
Polycythemia vera (PV) is a hematopoietic stem cell neoplasm driven by somatic mutations in JAK2 , leading to increased red blood cell (RBC)...
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Targeting CD47-SIRPa axis shows potent preclinical anti-tumor activity as monotherapy and synergizes with PARP inhibition
The objective was to correlate CD47 gene expression with resistance to immune checkpoint inhibitors (ICI) in tumor tissue of gynecological cancer...
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Utility of peripheral blood monocyte subsets, circulating immune complexes and serum cytokines in assessment of SLE activity: an observational, cross-sectional study
IntroductionSLE disease measurements by current standards are less than perfect. Monocytes and their subsets are part of innate immunity, and one of...
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Development of 68Ga-labeled tin colloids for evaluating phagocytic function of Kupffer cells using preclinical PET imaging
ObjectiveThis study aimed to investigate the optimal conditions for producing 68 Ga-labeled tin colloid and the feasibility of 68 Ga-tin colloid...
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Modulation of tumor-associated macrophage activity with radiation therapy: a systematic review
ObjectiveTumor-associated macrophages (TAMs) are the most represented cells of the immune system in the tumor microenvironment (TME). Besides its...
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VISTA drives macrophages towards a pro-tumoral phenotype that promotes cancer cell phagocytosis yet down-regulates T cell responses
BackgroundVISTA is a well-known immune checkpoint in T cell biology, but its role in innate immunity is less established. Here, we investigated the...
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Erythrocyte membrane integrity and protein activity in high-fat diet fed male Wistar rats
PurposeHigh-fat diet (HFD) has been reported to induce systemic inflammation and oxidative stress that may affect the structural integrity of...
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Standardized ethanol extract, essential oil and zerumbone of Zingiber zerumbet rhizome suppress phagocytic activity of human neutrophils
BackgroundZingiber zerumbet rhizome and its bioactive metabolites have previously been reported to exhibit innumerable pharmacological properties...
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Fine particulate matter 2.5 induces susceptibility to Pseudomonas aeruginosa infection via expansion of PD-L1high neutrophils in mice
BackgroundExposure to PM2.5 has been implicated in a range of detrimental health effects, particularly affecting the respiratory system. However, the...
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The ratio of neutrophil to lymphocyte as a potential marker of clinicopathological activity for lupus nephritis
IntroductionThe ratio of neutrophil to lymphocyte (NLR) is a novel inflammatory factor that is elevated in systemic lupus erythematosus (SLE)....
