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Laboratory Diagnostics of Ovarian Cancer among the Elderly Based on the Parameters of Immunoglobulins and Phagocytic Activity of Blood

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Abstract

New diagnostic methods are being sought for ovarian cancer due to its higher prevalence, which is the result of an increase in the share of elderly women. The purpose of this study was to analyze the content and sensitivity of immunoglobulins and the phagocytic activity of peripheral blood in order to improve the diagnostics of ovarian cancer among elderly women. The phagocytic activity and the immunoglobulin level in the peripheral blood were assessed with immunological and spectrophotometric methods in 78 patients with ovarian cancer aged 65–70 years. The control group comprised 42 women of the same age with no ovarian cancer. The primary importance of circulating immune complexes and the indices of neutrophil activity and the inhibition of phagocyte migration was established for laboratory diagnostics of ovarian cancer among elderly people. The use of highly informative parameters of systemic immunity may enhance the diagnostics of ovarian cancer in the elderly.

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Authors and Affiliations

  1. Southwest State University, 305040, Kursk, Russia

    N. M. Agarkov & D. S. Koptev

  2. Peoples’ Friendship University of Russia, 117198, Moscow, Russia

    D. I. Kicha

  3. Kursk State Medical University, 305041, Kursk, Russia

    V. V. Harchenko & Yu. Yu. Blinkov

  4. Voronezh State Technical University, 394026, Voronezh, Russia

    E. N. Korovin

  5. Pirogov First City Hospital, 119049, Moscow, Russia

    I. V. Budnik

Authors
  1. N. M. Agarkov
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  2. D. I. Kicha
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  3. V. V. Harchenko
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  4. D. S. Koptev
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  5. E. N. Korovin
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  6. Yu. Yu. Blinkov
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Correspondence to N. M. Agarkov.

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Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Translated by E. Sherstyuk

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Agarkov, N.M., Kicha, D.I., Harchenko, V.V. et al. Laboratory Diagnostics of Ovarian Cancer among the Elderly Based on the Parameters of Immunoglobulins and Phagocytic Activity of Blood. Adv Gerontol 10, 57–61 (2020). https://doi.org/10.1134/S2079057020010026

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  • DOI: https://doi.org/10.1134/S2079057020010026

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