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Uric acid levels and their association with vascular dementia and Parkinson’s disease dementia: a meta-analysis
ObjectivesTo explore the association between uric acid (UA) levels and vascular dementia (VaD) and Parkinson’s disease dementia (PDD), a...
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Glymphatic function from diffusion-tensor MRI to predict conversion from mild cognitive impairment to dementia in Parkinson’s disease
BackgroundAlthough brain glymphatic dysfunction is a contributing factor to the cognitive deficits in Parkinson’s disease (PD), its role in the...
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Cognitive impairment and dementia in young onset Parkinson’s disease
Background and objectivePatients with young-onset Parkinson’s disease (YOPD) have a slower progression. Our aim was to analyze the change in...
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Optimal Protocol and Clinical Usefulness of 123I-MIBG Cardiac Scintigraphy for Differentiation of Parkinson’s Disease and Dementia with Lewy Body from Non-Parkinson’s Diseases
Purpose123 I-metaiodobenzylguanidine (MIBG) cardiac scintigraphy was a useful imaging modality for the diagnosis of Parkinson’s disease, but its...
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Distinct tau and alpha-synuclein molecular signatures in Alzheimer’s disease with and without Lewy bodies and Parkinson’s disease with dementia
Alpha-synuclein (aSyn) pathology is present in approximately 50% of Alzheimer’s disease (AD) cases at autopsy and might impact the age-of-onset and...
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Protocol of a randomized controlled trial investigating Deep Brain Stimulation for MOtor symptoms in patients with Parkinson’s disease DEmentia (DBS-MODE)
BackgroundDeep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for disabling motor symptoms of Parkinson’s...
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Validation of the Italian version of the Parkinson’s Disease- Cognitive Functional Rating Scale
A key distinguishing factor between mild cognitive impairment (MCI) and dementia in Parkinson’s disease (PD) lies in the notable decrease in...
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Parkinson’s disease with hyposmia and dysautonomia: does it represent a distinct subtype?
Background and purposeOlfactory dysfunction or dysautonomia is one of the earliest prodromal nonmotor symptoms of Parkinson’s disease (PD). We aimed...
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Cognition and Activity of Daily Living Function in people with Parkinson’s disease
The ability to perform activities of daily living (ADL) function is a multifaceted construct that reflects functionality in different daily life...
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A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson’s disease
BackgroundCognitive impairment is a frequent disabling feature of Parkinson’s disease (PD). Orthostatic hypotension (OH) is treatable and may be a...
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A blood mRNA panel that differentiates Alzheimer’s disease from other dementia types
BackgroundMessenger RNAs (mRNAs) have been reported to be associated with Alzheimer’s disease (AD). In this study, we investigated whether...
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Deep venous thrombosis and hyponatremia associated with citalopram use for behavioral symptoms in Parkinson’s disease: a case report
BackgroundEvidence is limited regarding the optimal therapeutic approach for neuropsychiatric symptoms associated with Parkinson’s disease dementia...
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Psychiatric Adverse Events of Acetylcholinesterase Inhibitors in Alzheimer’s Disease and Parkinson’s Dementia: Systematic Review and Meta-Analysis
BackgroundThe acetylcholinesterase inhibitors (AChEIs) donepezil, galantamine, and rivastigmine are commonly used in the management of various forms...
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Mitochondrial DNA damage triggers spread of Parkinson’s disease-like pathology
In the field of neurodegenerative diseases, especially sporadic Parkinson’s disease (sPD) with dementia (sPDD), the question of how the disease...
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Association between cerebrospinal fluid pressure and cognition in patients with Alzheimer’s disease and Lewy body dementia
BackgroundThe relationship between cerebrospinal fluid pressure (CSFP) and cognition has received little research attention. The purpose of this...
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Prevalence, treatment, and neural correlates of apathy in different forms of dementia: a narrative review
ObjectivesThe aim of this review is to provide an overview on prevalence and clinical tools for the diagnosis of apathy, as well as on...
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Inflammatory markers and depression in Parkinson’s disease: a systematic review
BackgroundParkinson’s disease (PD) patients experience non-motor symptoms (NMS), which may appear before motor manifestations. The most common NMS is...
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Mendelian Randomization Analysis to Assess Whether Magnetic Resonance Imaging Signs of Cerebral Small Vessel Disease Can Cause Cognitive Decline and Dementia
ObjectiveCognitive decline and dementia have been linked to cerebral small vessel disease, so we explored using Mendelian randomization whether...
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The incidence, baseline predictors, and outcomes of dementia in an incident cohort of Parkinson’s disease and controls
BackgroundThere are few long-term data on the incidence, baseline predictors, and outcomes of dementia in Parkinson’s disease (PD) from prospective...
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Brainstem atrophy in dementia with Lewy bodies compared with progressive supranuclear palsy and Parkinson’s disease on MRI
BackgroundAlthough Dementia with Lewy bodies (DLB) is the second most common form of dementia in elderly patients, it remains underdiagnosed compared...
