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SLIC-Occ: functional segmentation of occupancy images improves precision of EC50 images
BackgroundDrug occupancy studies with positron emission tomography imaging are used routinely in early phase drug development trials. Recently, our...
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Neonatal intensive care unit occupancy rate and probability of discharge of very preterm infants
ObjectiveTo assess the association of NICU occupancy with probability of discharge and length of stay (LOS) among infants born <33 weeks gestational...
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Antipsychotic dose, dopamine D2 receptor occupancy and extrapyramidal side-effects: a systematic review and dose-response meta-analysis
Antipsychotic drugs differ in their propensity to cause extrapyramidal side-effects (EPS), but their dose-effects are unclear. Therefore, we...
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Assessment of cerebral drug occupancy in humans using a single PET-scan: A [11C]UCB-J PET study
PurposeHere, we evaluate a PET displacement model with a Single-step and Numerical solution in healthy individuals using the synaptic vesicle...
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ABCB1 variants and sex affect serotonin transporter occupancy in the brain
Strategies to personalize psychopharmacological treatment promise to improve efficacy and tolerability. We measured serotonin transporter occupancy...
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Nurses’ perceptions of the transition to 100% single-occupancy patient rooms in a university hospital in the Netherlands: an uncontrolled before and after study
BackgroundTo improve patients’ privacy, comfort and infection control, newly built hospitals increasingly offer 100% single-occupancy patient rooms....
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The association between bed occupancy rates and hospital quality in the English National Health Service
We study whether hospitals that exhibit systematically higher bed occupancy rates are associated with lower quality in England over 2010/11–2017/18....
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Mobility level and factors affecting mobility status in hospitalized patients admitted in single-occupancy patient rooms
BackgroundAlthough stimulating patients’ mobility is considered a component of fundamental nursing care, approximately 35% of hospitalized patients...
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A quadruple peripheral nerve block outside the OR for anterior cruciate ligament reconstruction reduces the OR occupancy time
PurposeThe use of regional anesthesia (RA) for anterior cruciate ligament (ACL) reconstruction reduces morphine consumption, the time spent in the...
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Prediction of ROS1 and TRKA/B/C occupancy in plasma and cerebrospinal fluid for entrectinib alone and in DDIs using physiologically based pharmacokinetic (PBPK) modeling approach
PurposeEntrectinib (ENT) is a potent c-ros oncogene 1(ROS1) and neurotrophic tyrosine receptor kinase (NTRKA/B/C) inhibitor. To determine the optimum...
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Importance of ventilation and occupancy to Mycobacterium tuberculosis transmission rates in congregate settings
BackgroundVentilation rates are a key determinant of the transmission rate of Mycobacterium tuberculosis and other airborne infections. Targeting...
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The relationship between dose and serotonin transporter occupancy of antidepressants—a systematic review
Brain imaging techniques enable the visualization of serotonin transporter (SERT) occupancy as a measure of the proportion of SERT blocked by an...
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Diagnosis of cardiac occupancy as metachronous carcinoma using multimodal imaging: a case report
BackgroundMetachronous carcinoma presenting as a cardiac malignancy is rare, and timely diagnosis is critical. We report a patient with a primary...
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Target occupancy study and whole-body dosimetry with a MAGL PET ligand [11C]PF-06809247 in non-human primates
BackgroundMonoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven...
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EC50 images, a novel endpoint from PET target occupancy studies, reveal spatial variation in apparent drug affinity
PurposeWe recently introduced voxel-level images of drug occupancy from PET via our “Lassen plot filter.” Occupancy images revealed clear dependence...
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The association between mechanical ventilator compatible bed occupancy and mortality risk in intensive care patients with COVID-19: a national retrospective cohort study
BackgroundThe literature paints a complex picture of the association between mortality risk and ICU strain.
In this study, we sought to determine if...
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Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England
BackgroundPredicting bed occupancy for hospitalised patients with COVID-19 requires understanding of length of stay (LoS) in particular bed types....
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Pharmacokinetic and pharmacodynamic assessment of histamine H3 receptor occupancy by enerisant: a human PET study with a novel H3 binding ligand, [11C]TASP457
PurposeHistamine H 3 receptor antagonists and inverse agonists have been extensively developed to treat sleep–wake, neurocognitive, and allied...
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Occupancy modeling and resampling overcomes low test sensitivity to produce accurate SARS-CoV-2 prevalence estimates
BackgroundWe evaluated whether occupancy modeling, an approach developed for detecting rare wildlife species, could overcome inherent accuracy...
