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Nonhuman Primate Welfare From History, Science, and Ethics to Practice
This volume reviews the broad topic of welfare in nonhuman primates under human care. Chapters detail the history of primates in captivity, ethical...
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Nonhuman primate genetic models for the study of rare diseases
Pre-clinical research and development relies heavily upon translationally valid models of disease. A major difficulty in understanding the biology...
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Atlas of Diagnostic Pathology in Nonhuman Primates
The Atlas of Diagnostic Pathology in Nonhuman Primates offers the first extensively illustrated collection of classic lesions in nonhuman primate...
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Extracellular free water elevations are associated with brain volume and maternal cytokine response in a longitudinal nonhuman primate maternal immune activation model
Maternal infection has emerged as an important environmental risk factor for neurodevelopmental disorders, including schizophrenia and autism...
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Alterations in adolescent brain serotonin (5HT)1A, 5HT2A, and dopamine (D)2 receptor systems in a nonhuman primate model of early life adversity
Stress affects brain serotonin (5HT) and dopamine (DA) function, and the effectiveness of 5HT and DA to regulate stress and emotional responses....
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Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET)
PurposeExploring synaptic density changes during brain growth is crucial to understanding brain development. Previous studies in nonhuman primates...
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Atlas-based liver segmentation for nonhuman primate research
PurposeCertain viral infectious diseases cause systemic damage and the liver is an important organ affected directly by the virus and/or the hosts’...
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The Movement of Pathogen Carrying Flies at the Human–Wildlife Interface
Flies form high-density associations with human settlements and groups of nonhuman primates and are implicated in transmitting pathogens. We...
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Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates
PurposeCurrently, there are multiple active clinical trials involving poly(ADP-ribose) polymerase (PARP) inhibitors in the treatment of glioblastoma....
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A preliminary study of the effects of an antimuscarinic agent on anxious behaviors and white matter microarchitecture in nonhuman primates
Myelination subserves efficient neuronal communication, and alterations in white matter (WM) microstructure have been implicated in numerous...
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Evaluation of a Magnetic Compression Anastomosis for Jejunoileal Partial Diversion in Rhesus Macaques
PurposeMetabolic surgery remains underutilized for treating type 2 diabetes, as less invasive alternative interventions with improved risk profiles...
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Placental Glucose Uptake in a Nonhuman Primate Model of Western-Style Diet Consumption and Chronic Hyperandrogenemia Exposure
We reported that consumption of a western-style diet (WSD) with and without hyperandrogenemia perturbed placental perfusion and altered levels of...
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A nonhuman primate model of human non-suicidal self-injury: serotonin-transporter genotype-mediated typologies
While non-suicidal self-injury (NSSI) occurs in the general population at a surprisingly high rate, with higher rates among certain clinical...
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The Brain Retains: Nonhuman Primate Models for Pediatric HIV-1 in the CNS
Purpose of ReviewPerinatal HIV-1 infection is associated with an increased risk for neurologic impairments. With limited access to clinical...
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Long-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates
Messenger RNA (mRNA) vaccine technology has shown its power in preventing the ongoing COVID-19 pandemic. Two mRNA vaccines targeting the full-length...
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Quantitative PET imaging of the CD4 pool in nonhuman primates
PurposePrevious SPECT and PET semi-quantitative in vivo imaging studies in monkeys have demonstrated specific uptake of radiolabeled rhesus...
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Uterine Autotransplantation in the Nonhuman Primate With Preservation of the Uterine and Ovarian Vascular Pedicles
Purpose: To evaluate the technical feasibility of performing a uterine autotransplantation in the nonhuman primate while preserving the uterine and...
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Multifocal electroretinography increases following experimental glaucoma in nonhuman primates with retinal ganglion cell axotomy
PurposeTo determine whether short-latency changes in multifocal electroretinography (mfERG) observed in experimental glaucoma (EG) are secondary...
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The Primate Cultural Significance Index: applications with Popoluca Indigenous people at Los Tuxtlas Biosphere Reserve
BackgroundThe study of the cultural significance (CS) of biodiversity provides key information to develop conservation strategies consistent with...
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The gut microbiome modulates gut–brain axis glycerophospholipid metabolism in a region-specific manner in a nonhuman primate model of depression
Emerging research demonstrates that microbiota-gut–brain (MGB) axis changes are associated with depression onset, but the mechanisms underlying this...
