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Role of neuroinflammation in neurodegeneration development
Studies in neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease and Amyotrophic lateral sclerosis, Huntington’s disease,...
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Olfactory status in neurodegeneration with brain iron accumulation disorders
BackgroundOlfactory dysfunction has been suggested as a diagnostic and discriminative biomarker in some neurodegenerative disorders. However, there...
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Therapie – Quo vadis Neurodegeneration?
BackgroundHallmarks of neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease are pathological protein aggregation,...
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The glymphatic system’s role in traumatic brain injury-related neurodegeneration
In at least some individuals who suffer a traumatic brain injury (TBI), there exists a risk of future neurodegenerative illness. This review focuses...
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Neuroinflammation and neurodegeneration following traumatic brain injuries
Traumatic brain injuries (TBI) commonly occur following head trauma. TBI may result in short- and long-term complications which may lead to...
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Revisiting the critical roles of reactive astrocytes in neurodegeneration
Astrocytes, an integral component of the central nervous system (CNS), contribute to the maintenance of physiological homeostasis through their roles...
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Zusammenhänge zwischen Mikrobiom und Neurodegeneration
BackgroundNeurodegenerative diseases are often associated with changes in the (gut) microbiome.
ObjectiveBased on studies in Parkinson’s disease...
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The necroptosis cell death pathway drives neurodegeneration in Alzheimer’s disease
Although apoptosis, pyroptosis, and ferroptosis have been implicated in AD, none fully explains the extensive neuronal loss observed in AD brains....
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Role of sleep in neurodegeneration: the consensus report of the 5th Think Tank World Sleep Forum
Sleep abnormalities may represent an independent risk factor for neurodegeneration. An international expert group convened in 2021 to discuss the...
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Magnetic resonance metrics for identification of cuprizone-induced demyelination in the mouse model of neurodegeneration: a review
Neurodegenerative disorders, including Multiple Sclerosis (MS), are heterogenous disorders which affect the myelin sheath of the central nervous...
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Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice
TMEM106B , a gene encoding a lysosome membrane protein, is tightly associated with brain aging, hypomyelinating leukodystrophy, and multiple...
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Iron imbalance in neurodegeneration
Iron is an essential element for the development and functionality of the brain, and anomalies in its distribution and concentration in brain tissue...
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Validation of brain parenchyma sonography as a marker of neurodegeneration in multiple sclerosis
BackgroundMultiple sclerosis (MS) is widely known to cause brain atrophy due to neurodegeneration. Neuroimaging investigations revealed a direct link...
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Understanding the relationship between type-2 diabetes, MRI markers of neurodegeneration and small vessel disease, and dementia risk: a mediation analysis
To explore to which extent neurodegeneration and cerebral small vessel disease (SVD) could mediate the association between type-2 diabetes and higher...
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A Genetic Validation of the Neurodegeneration Biomarkers Tau-A and Tau-C - A Mendelian Randomization Study
BackgroundDisease modifying treatments for dementia are only just surfacing, and their development is still significantly hindered by the lack of...
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The first reports of FA2H-associated neurodegeneration from two unrelated Iranian families
BackgroundNBIA (neurodegeneration with brain iron accumulation) is a diverse collection of neurodegenerative illnesses defined by iron accumulation...
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Retinal neurodegeneration in diabetic retinopathy with systemic hypertension
PurposeTo identify the impact of hypertension (HTN) on inner retinal layer thickness in patients with diabetic retinopathy (DR).
Methods ...
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Mutant LRRK2 exacerbates immune response and neurodegeneration in a chronic model of experimental colitis
The link between the gut and the brain in Parkinson’s disease (PD) pathogenesis is currently a subject of intense research. Indeed, gastrointestinal...
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Neurodegeneration with brain iron accumulation: a case series highlighting phenotypic and genotypic diversity in 20 Indian families
Neurodegeneration with brain iron accumulation (NBIA) is an umbrella term encompassing various inherited neurological disorders characterised by...
