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Mitochondrial, cell cycle control and neuritogenesis alterations in an iPSC-based neurodevelopmental model for schizophrenia
Schizophrenia is a severe psychiatric disorder of neurodevelopmental origin that affects around 1% of the world’s population. Proteomic studies and...
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The cytoplasmic localization of ADNP through 14-3-3 promotes sex-dependent neuronal morphogenesis, cortical connectivity, and calcium signaling
Defective neuritogenesis is a contributing pathogenic mechanism underlying a variety of neurodevelopmental disorders. Single gene mutations in...
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A muscarinic receptor antagonist reverses multiple indices of diabetic peripheral neuropathy: preclinical and clinical studies using oxybutynin
Preclinical studies indicate that diverse muscarinic receptor antagonists, acting via the M 1 sub-type, promote neuritogenesis from sensory neurons in...
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Psychedelics for acquired brain injury: a review of molecular mechanisms and therapeutic potential
Acquired brain injury (ABI), such as traumatic brain injury and stroke, is a leading cause of disability worldwide, resulting in debilitating acute...
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Transcriptome profiling of a synergistic volumetric muscle loss repair strategy
Volumetric muscle loss overwhelms skeletal muscle’s ordinarily capable regenerative machinery, resulting in severe functional deficits that have...
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Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model
BackgroundThis study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile...
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The role of neurotrophic factors in novel, rapid psychiatric treatments
Neurotrophic factors are a family of growth factors that modulate cellular growth, survival, and differentiation. For many decades, it has been...
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Hippocampal transcriptome-wide association study and pathway analysis of mitochondrial solute carriers in Alzheimer’s disease
The etiopathogenesis of late-onset Alzheimer’s disease (AD) is increasingly recognized as the result of the combination of the aging process, toxic...
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Key role of Rho GTPases in motor disorders associated with neurodevelopmental pathologies
Growing evidence suggests that Rho GTPases and molecules involved in their signaling pathways play a major role in the development of the central...
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Two different presentations of de novo variants of CSNK2B: two case reports
BackgroundPoirier–Bienvenu neurodevelopmental syndrome is a neurologic disorder caused by mutations in the CSNK2B gene. It is mostly characterized...
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Current trends in basic research on Parkinson’s disease: from mitochondria, lysosome to α-synuclein
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra...
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The interaction of early life factors and depression-associated loci affecting the age at onset of the depression
Multiple previous studies explored the associations between early life factors and the age at onset of the depression. However, they only focused on...
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Serotonergic psychedelic 5-MeO-DMT alters plasticity-related gene expression and generates anxiolytic effects in stressed mice
Serotonergic psychedelics have potential therapeutic effects in treating anxiety and mood disorders, often after a single dose, and are suggested to...
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Expanding the genetic and phenotypic relevance of CLCN4 variants in neurodevelopmental condition: 13 new patients
ObjectivesCLCN4 variations have recently been identified as a genetic cause of X-linked neurodevelopmental disorders . This study aims to broaden the...
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Epigenome-wide analysis identifies methylome profiles linked to obsessive-compulsive disorder, disease severity, and treatment response
Obsessive-compulsive disorder (OCD) is a prevalent mental disorder affecting ~2–3% of the population. This disorder involves genetic and, possibly,...
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Pretreatment with combined low-level laser therapy and methylene blue improves learning and memory in sleep-deprived mice
Low-level laser therapy (LLLT) and methylene blue (MB) were proved to have neuroprotective effects. In this study, we evaluated the preventive...
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Long-term ayahuasca use is associated with preserved global cognitive function and improved memory: a cross-sectional study with ritual users
Although several studies have been conducted to elucidate the relationship between psychedelic consumption and cognition, few have focused on...
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Icariin Ameliorates D-galactose-induced Cell Injury in Neuron-like PC12 Cells by Inhibiting MPTP Opening
ObjectiveIcariin (ICA) has a good neuroprotective effect and can upregulate neuronal basal autophagy in naturally aging rats. Mitochondrial...
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Occurrence and Prognostic Value of Perineural Invasion in Esophageal Squamous Cell Cancer: A Retrospective Study
ObjectiveThe aim of this study was to explore the occurrence and prognostic value of perineural invasion (PNI) as a classic tumor pathological...
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Decreased FAK activity and focal adhesion dynamics impair proper neurite formation of medium spiny neurons in Huntington's disease
Huntington's disease (HD) is a neurodegenerative disorder caused by a polyglutamine expansion in the protein huntingtin (HTT) [55]. While the final...
