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Infectious mononucleosis complicated by transitory Epstein-Barr virus infection of T and natural killer cells
Epstein-Barr virus (EBV) typically infects B cells in infectious mononucleosis (IM), but a rare case shows EBV infection in T cells. Seven cases of...
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Overcoming resistance to programmed cell death protein 1 (PD-1) blockade with allogeneic invariant natural killer T-cells (iNKT)
Gastric cancer is the 5 th most common malignancy worldwide with only 36% of patients with metastatic disease surviving beyond 5 years. Despite...
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Novel target and treatment agents for natural killer/T-cell lymphoma
The rapidly increasing use of high-throughput screening had produced a plethora of expanding knowledge on the molecular basis of natural...
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Immune profiling of patients with extranodal natural killer/T cell lymphoma treated with daratumumab
Natural killer/T cell lymphoma (NKTCL) is a highly aggressive, heterogeneous non-Hodgkin lymphoma resulting from malignant proliferation of cytotoxic...
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Increased ILT2+ natural killer T cells correlate with disease activity in systemic lupus erythematosus
ObjectiveNumerous immune cell types, such as B and T lymphocytes, natural killer cells (NK), and NKT cells, are related to the pathogenesis of...
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Targeting natural killer cells: from basic biology to clinical application in hematologic malignancies
Natural killer (NK) cell belongs to innate lymphoid cell family that contributes to host immunosurveillance and defense without pre-immunization....
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Decreased natural killer T-like cells correlated to disease activity in systemic lupus erythematosus
ObjectivesTo evaluate the absolute numbers and frequencies of natural killer T-like (NKT-like) cells in systemic lupus erythematosus (SLE) and to...
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Coexpression of natural killer cell antigens by T-cell large granular lymphocytes in hydroa vacciniforme lymphoproliferative disorder and the involvement of Vδ1 + epithelial-type γδT cells
Hydroa vacciniforme lymphoproliferative disorder (HV-LPD) is a cutaneous variant of chronic active Epstein–Barr virus disease. We examined the...
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Chimeric antigen receptor engineered natural killer cells for cancer therapy
Natural killer (NK) cells, a unique component of the innate immune system, are inherent killers of stressed and transformed cells. Based on their...
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Extranodal natural killer/T-cell lymphoma with hepatosplenic involvement: a retrospective study of a consecutive 14-year case series
Extranodal natural killer/T-cell lymphoma (ENKTL) with hepatosplenic involvement is rare, accounting for approximately 0.2% of ENKTL cases. The...
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Extranodal natural killer/T cell lymphoma of the skeletal muscle
This case report highlights a case of extranodal NK/T cell lymphoma initially misdiagnosed as myositis, emphasizing the appearance on both MRI and...
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Natural killer cells strengthen antitumor activity of cisplatin by immunomodulation and ameliorate cisplatin-induced side effects
PurposeCisplatin-based chemotherapy is now an important treatment for improving bladder cancer prognosis. However, challenges in clinical treatment...
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Diminished natural killer T-like cells correlates with aggravated primary Sjögren’s syndrome
ObjectiveTo reveal the characteristics and potential role of natural killer T-like cells (NKT-like cells) in the pathogenesis of primary Sjögren’s...
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Elevated serum IL-6 and total IgEAb are associated with poor survival in natural killer/T-cell lymphoma
Natural killer/T‐cell lymphoma (NKTCL) is an aggressive and malignant condition with a high mortality rate. Prognostic factors may assist to evaluate...
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Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma
Natural killer T cell lymphoma (NKTCL) is highly aggressive, with advanced stage patients poorly responding to intensive chemotherapy. To explore...
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The prognostic value of controlling nutritional status (CONUT) score–based nomogram on extranodal natural killer/T cell lymphoma patients
Controlling nutritional status (CONUT) score as an original nutritional assessment tool can be used to assess the prognosis of patients with a...
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Myeloid-derived Suppressor Cells Activate Liver Natural Killer Cells in a Murine Model in Uveal Melanoma
ObjectiveElevated myeloid-derived suppressor cells (MDSCs) in many malignancies are associated with the increased risk for metastases and poor...
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Enhanced efficacy of combined fluzoparib and chidamide targeting in natural killer/T-cell lymphoma
The treatment of natural killer/T-cell lymphoma (NKTCL) presents an onerous challenge, and a search for new therapeutic targets is urgently needed....
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Evolution of natural killer cell-targeted therapy for acute myeloid leukemia
In hematologic oncology, acute myeloid leukemia (AML) presents a significant challenge due to its complex genetic landscape and resistance to...
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Natural killer cell immunotherapy in glioblastoma
Glioblastoma (GBM) is one of the most difficult cancers to treat because GBM has the high therapeutic resistance. Recently, immunotherapies for GBM...
