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NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression
Colorectal cancer (CRC) is a prevalent and aggressive malignancy with high mortality rates and significant risks to human well-being. Population-wide...
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Association of NLRPs with pathogenesis of dry age-related macular degeneration
BackgroundAge-related macular degeneration (AMD) is the leading cause of blindness in the elderly population, and Dry AMD is the most common clinical...
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The dual role of autophagy in HPV-positive head and neck squamous cell carcinoma: a systematic review
PurposeHuman papilloma virus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) displays distinct epidemiological, clinical, and molecular...
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Immunometabolic rewiring of tubular epithelial cells in kidney disease
Kidney tubular epithelial cells (TECs) have a crucial role in the damage and repair response to acute and chronic injury. To adequately respond to...
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Activation of cell-free mtDNA-TLR9 signaling mediates chronic stress-induced social behavior deficits
Inflammation and social behavior deficits are associated with a number of neuropsychiatric disorders. Chronic stress, a major risk factor for...
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Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response
Adolescent individuals exhibit great variability in cortical dynamics and behavioral outcomes. The develo** adolescent brain is highly sensitive to...
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Mitophagy plays a “double-edged sword” role in the radiosensitivity of cancer cells
Mitochondria are organelles with double-membrane structure of inner and outer membrane, which provides main energy support for cell growth and...
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Role of Gut Microbiome in Immune Regulation and Immune Checkpoint Therapy of Colorectal Cancer
Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignant tumors worldwide. Immune checkpoint therapies (ICTs) have been proven...
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Splenic proteome profiling in response to Marek’s disease virus strain GX0101 infection
Marek’s disease virus (MDV) strain GX0101 was the first reported field strain of recombinant gallid herpesvirus type 2 (GaHV-2). However, the splenic...
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The role of NLRP3 inflammasome in colorectal cancer: potential therapeutic target
All phases of carcinogenesis are affected by inflammation. Activation of the inflammasome is a crucial signaling mechanism that leads to acute and...
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ZNF283, a Krüppel-associated box zinc finger protein, inhibits RNA synthesis of porcine reproductive and respiratory syndrome virus by interacting with Nsp9 and Nsp10
Porcine reproductive and respiratory syndrome virus (PRRSV) is a viral pathogen with substantial economic implications for the global swine industry....
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Innate immune responses in pneumonia
The lungs are an immunologically unique environment; they are exposed to innumerable pathogens and particulate matter daily. Appropriate clearance of...
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NOD-like receptor X1 functions as a tumor suppressor by inhibiting epithelial-mesenchymal transition and inducing aging in hepatocellular carcinoma cells
BackgroundThis study was performed to investigate the role of nucleotide-binding oligomerization domain (NOD)-like receptor X1 (NLRX1) in regulating...
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Novel GSDMD inhibitor GI-Y1 protects heart against pyroptosis and ischemia/reperfusion injury by blocking pyroptotic pore formation
Activation of gasdermin D (GSDMD) and its concomitant cardiomyocyte pyroptosis are critically involved in multiple cardiac pathological conditions....
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Salidroside protects RGC from pyroptosis in diabetes-induced retinopathy associated with NLRP3, NFEZL2 and NGKB1, revealed by network pharmacology analysis and experimental validation
ObjectiveTo investigate the effect of salidroside (SAL) in protecting retinal ganglion cell (RGC) from pyroptosis and explore associated molecular...
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COPB2: a transport protein with multifaceted roles in cancer development and progression
The Coatomer protein complex subunit beta 2 (COPB2) is involved in the formation of the COPI coatomer protein complex and is responsible for the...
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Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy
Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for cytosolic DNA sensation and interferon (IFN) induction,...
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Hematopoiesis and innate immunity: an inseparable couple for good and bad times, bound together by an hormetic relationship
Hematopoietic and immune cells originate from a common hematopoietic/lymphopoietic stem cell what explains that these different cell types often...
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2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis
Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide + (NAD + )-dependent deacetylase located in the mitochondria that may...
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Differential sperm proteomic profiles according to pregnancy achievement in intracytoplasmic sperm injection cycles: a pilot study
PurposeTo describe the proteomic profiles in semen samples and define the differences in sperm proteomic profiles among samples that ultimately...
