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Myostatin expression in lung cancer induces sarcopenia and promotes cancer progression
ObjectivesMany studies have demonstrated that sarcopenia among lung cancer predicts poor prognosis due to cancer progression. However, the cytokines...
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The Clinical Development of Taldefgrobep Alfa: An Anti-Myostatin Adnectin for the Treatment of Duchenne Muscular Dystrophy
IntroductionDuchenne muscular dystrophy (DMD) is a genetic muscle disorder that manifests during early childhood and is ultimately fatal. Recently...
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Serum myostatin levels are associated with physical function and hospitalization in peritoneal dialysis patients
BackgroundMyostatin functions as a negative regulator of skeletal muscle growth. The association of myostatin with muscle parameters in dialysis...
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Muscular myostatin gene expression and plasma concentrations are decreased in critically ill patients
BackgroundThe objective was to investigate the role of gene expression and plasma levels of the muscular protein myostatin in intensive care...
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Myostatin serum levels in children with type 1 diabetes mellitus
PurposeType 1 diabetes mellitus (T1DM) can cause several complications, among them myopathy, which can appear even in adolescents. This is of...
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High-intensity circuit training change serum myostatin but not myogenin in adolescents’ soccer players: a quasi-experimental study
BackgroundSkeletal muscle contractions due to exercise lead to the secretion of many proteins and proteoglycan peptides called myokines. Myostatin...
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Lower myostatin and higher MUC1 levels are associated with better response to mepolizumab and omalizumab in asthma: a protein–protein interaction analyses
IntroductionBiomarkers are needed to inform the choice of biologic therapy in patients with asthma given the increasing number of biologics . We...
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Decreased myostatin in response to a controlled DASH diet is associated with improved body composition and cardiometabolic biomarkers in older adults: results from a controlled-feeding diet intervention study
BackgroundElevated concentrations of myostatin inhibit muscle growth, function and strength. Myostatin is a mediator of sarcopenia and is associated...
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Effects of functional training with blood occlusion on the irisin, follistatin, and myostatin myokines in elderly men
BackgroundThis study aimed to determine the efficacy of functional training with and without blood flow restriction (BFR) on muscle hypertrophy...
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Myostatin: a multifunctional role in human female reproduction and fertility – a short review
Myostatin (MSTN) is member of the transforming growth factor β (TGF-β) superfamily and was originally identified in the musculoskeletal system as a...
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The relationship between changes in serum myostatin and adiponectin levels in patients with obesity undergoing a weight loss program
BackgroundAn effective strategy for weight loss in patients who are overweight or obese is to reduce body fat mass while maintaining skeletal muscle...
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Changes in Serum Myostatin Levels in Alcoholic Hepatitis Correlate with Improvement in MELD
BackgroundAlcoholic hepatitis (AH) is a serious clinical syndrome often associated with muscle wasting. Myostatin, a member of the transforming...
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A Randomized Phase 1 Safety, Pharmacokinetic and Pharmacodynamic Study of the Novel Myostatin Inhibitor Apitegromab (SRK-015): A Potential Treatment for Spinal Muscular Atrophy
IntroductionApitegromab (SRK-015) is an anti-promyostatin monoclonal antibody under development to improve motor function in patients with spinal...
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Evaluation of myostatin as a possible regulator and marker of skeletal muscle–cortical bone interaction in adults
IntroductionBone mass was recently reported to be related to skeletal muscle mass in humans, and a decrease in cortical bone is a risk factor for...
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Myostatin and markers of bone metabolism in dermatomyositis
BackgroundIn dermatomyostis (DM) patients, inflammation, reduced activity, and medication have a negative impact on the musculoskeletal system....
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MyomiRNAs and myostatin as physical rehabilitation biomarkers for myotonic dystrophy
MiR-1 and myostatin are markers for muscle growth and regeneration. Myostatin has a key role in the regulation of muscle mass. Myotonic dystrophy...
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Advances and limitations for the treatment of spinal muscular atrophy
Spinal muscular atrophy (5q-SMA; SMA), a genetic neuromuscular condition affecting spinal motor neurons, is caused by defects in both copies of the SMN1...
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Crosstalk between muscle and bone
Clinical studies revealed a relationship between osteoporosis and sarcopenia. Based on this background, crosstalk between muscle and bone has emerged...
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Significance of serum Myostatin in hemodialysis patients
BackgroundMalnutrition and muscle wasting are common in haemodialysis (HD) patients. Their pathogenesis is complex and involves many molecules...
