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**nbao Pill ameliorates heart failure via regulating the SGLT1/AMPK/PPARα axis to improve myocardial fatty acid energy metabolism
BackgroundHeart failure (HF) is characterized by a disorder of cardiomyocyte energy metabolism. **nbao Pill (XBW), a traditional Chinese medicine...
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Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation
BackgroundCardiovascular diseases, including diabetic cardiomyopathy, are major causes of death in people with type 2 diabetes. Aldose reductase...
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Bawei Chenxiang Wan ameliorates right ventricular hypertrophy in rats with high altitude heart disease by SIRT3-HIF1α-PDK/PDH signaling pathway improving fatty acid and glucose metabolism
BackgroundBawei Chenxiang Wan ( BCW ) is among the most effective and widely used therapies for coronary heart disease and angina pectoris in Tibet....
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Myocardial Metabolism in Heart Failure
Purpose of ReviewMyocardial metabolism is intricately linked to cardiac function. Perturbations of cardiac energy metabolism result in an...
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Pharmacological Effects of Botanical Drugs on Myocardial Metabolism in Chronic Heart Failure
Although there have been significant advances in the treatment of heart failure in recent years, chronic heart failure remains a leading cause of...
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Dual roles of myocardial mitochondrial AKT on diabetic cardiomyopathy and whole body metabolism
BackgroundThe PI3K/AKT pathway transduces the majority of the metabolic actions of insulin. In addition to cytosolic targets, insulin-stimulated...
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Targeting Myocardial Substrate Metabolism in the Failing Heart: Ready for Prime Time?
Purpose of ReviewWe review the clinical benefits of altering myocardial substrate metabolism in heart failure.
Recent FindingsModulation of cardiac...
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The abnormalities of free fatty acid metabolism in patients with hypertrophic cardiomyopathy, a single-center retrospective observational study
BackgroundPrevious studies have shown the importance of energy deficiency and malfunctioning mitochondria in the pathophysiology of hypertrophic...
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Pancreatic fatty replacement as risk marker for altered glucose metabolism and cardiac iron and complications in thalassemia major
ObjectivesThis multicenter study assessed the extent of pancreatic fatty replacement and its correlation with demographics, iron overload, glucose...
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Serum metabolism characteristics of patients with myocardial injury after noncardiac surgery explored by the untargeted metabolomics approach
BackgroundMyocardial injury after noncardiac surgery (MINS) is one of the most common complications associated with postoperative adverse...
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Finerenone attenuates myocardial apoptosis, metabolic disturbance and myocardial fibrosis in type 2 diabetes mellitus
BackgroundFinerenone is a third-generation mineralocorticoid receptor antagonists, which has shown good cardiac function improvement in patients with...
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Dynamic evolution and mechanism of myocardial glucose metabolism in different functional phenotypes of diabetic cardiomyopathy — a study based on 18 F-FDG microPET myocardial metabolic imaging
PurposeTo use 18 F-FDG microPET dynamic imaging to preliminarily identify the changes of myocardial glucose metabolism corresponding to different...
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Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy
BackgroundDiabetic cardiomyopathy (DCM) causes the myocardium to rely on fatty acid β-oxidation for energy. The accumulation of intracellular lipids...
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Amino acid metabolism in health and disease
Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth,...
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Eicosapentaenoic Acid Preserves Mitochondrial Quality and Attenuates Cardiac Remodeling After Myocardial Infarction in Rats
Eicosapentaenoic acid (EPA) reduces the risk of ischemic heart diseases and is a component of mitochondria. We herein investigated whether dietary...
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Myocardial complications induced by hypothyroidism in rats: effects of metformin and alpha lipoic acid
Hypothyroidism has adverse effects on heart metabolism and functions including reduced heart rate, cardiac output and cardiac contractility. The...
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Silencing the FABP3 gene in insulin-secreting cells reduces fatty acid uptake and protects against lipotoxicity
BackgroundLong-term exposure of pancreatic islets to fatty acids (FAs), common in obesity, metabolic syndrome, and type 2 diabetes, leads to a...
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Protective role of arachidonic acid against diabetic myocardial ischemic injury: a translational study of pigs, rats, and humans
AimPatients with diabetes mellitus have poor prognosis after myocardial ischemic injury. However, the mechanism is unclear and there are no related...
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Management of Cardiovascular Diseases by Short-Chain Fatty Acid Postbiotics
Purpose of ReviewGlobal health concerns persist in the realm of cardiovascular diseases (CVDs), necessitating innovative strategies for both...
