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Prospective flow cytometry analysis of leucocyte subsets in critically ill patients who develop sepsis: a pilot study
PurposeSepsis in critically ill patients with injury bears a high morbidity and mortality. Extensive phenotypic monitoring of leucocyte subsets in...
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Adjunctive immunotherapeutic agents in patients with sepsis and septic shock: a multidisciplinary consensus of 23
BackgroundIn the last decades, several adjunctive treatments have been proposed to reduce mortality in septic shock patients. Unfortunately,...
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Blood inflammatory biomarkers predict in-hospital pneumonia after endovascular treatment of aneurysm in patients with aneurysmal subarachoid hemorrhage
The systemic inflammatory response index (SIRI) is a well-known marker of systemic inflammation reflecting the body’s inflammatory/immune state. The...
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Estrogen-sensitive activation of SGK1 induces M2 macrophages with anti-inflammatory properties and a Th2 response at the maternal–fetal interface
BackgroundDecidual macrophages participate in immune regulation at the maternal–fetal interface. Abnormal M1/M2 polarization of decidual macrophages...
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Melissa officinalis extract palliates redox imbalance and inflammation associated with hyperthyroidism-induced liver damage by regulating Nrf-2/ Keap-1 gene expression in γ-irradiated rats
BackgroundMelissa officinalis (MO) is a well-known medicinal plant species used in the treatment of several diseases; it is widely used as a...
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Hepatic inflammatory responses in liver fibrosis
Chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) or viral hepatitis are characterized by persistent inflammation and...
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Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34+ hematopoietic stem cells from diabetic patients
BackgroundDiabetes-induced trained immunity contributes to the development of atherosclerosis and its complications. This study aimed to investigate...
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Leukocyte differential gene expression prognostic value for high versus low seizure frequency in temporal lobe epilepsy
BackgroundThis study was performed to test the hypothesis that systemic leukocyte gene expression has prognostic value differentiating low from high...
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Use of extracorporeal immunomodulation in a toddler with hemophagocytic lymphohistiocytosis and multisystem organ failure
IntroductionHemophagocytic lymphohistiocytosis (HLH) is a dysregulated immune disorder in children, associated with Epstein–Barr virus (EBV)...
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Association of clinical biomarkers and response to neoadjuvant therapy in breast cancer
IntroductionNeoadjuvant therapy is an essential component of multimodality therapy for locally advanced breast adenocarcinoma (BC). Complete...
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Upregulated microRNA-125b-5p in patients with asthma-COPD overlap mediates oxidative stress and late apoptosis via targeting IL6R/TRIAP1 signaling
BackgroundAmong patients with chronic obstructive pulmonary disease (COPD), some have features of both asthma and COPD—a condition categorized as...
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Clinical impact of transient lymphopenia
Transient or persistent immunosuppression is a known risk factor for morbidity and mortality in critically ill patients. Aim of the present study is...
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A journey to vasculopathy in systemic sclerosis: focus on haemostasis and thrombosis
Systemic sclerosis is a multisystem connective tissue disease, characterized by endothelial autoimmune activation, along with tissue and vascular...
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Traumatic inflammatory response: pathophysiological role and clinical value of cytokines
Severe trauma is an intractable problem in healthcare. Patients have a widespread immune system response that is complex and vital to survival....
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Biological Rationale for Peripheral Blood Cell–Derived Inflammatory Indices and Related Prognostic Scores in Patients with Advanced Non-Small-Cell Lung Cancer
Purpose of reviewTo describe the biological rationale of peripheral blood cells (PBC)–derived inflammatory indexes and assess the related prognostic...
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Organ-on-a-chip models for development of cancer immunotherapies
Cancer immunotherapy has emerged as a promising approach in the treatment of diverse cancer types. However, the development of novel...
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The Break-Fast study protocol: a single arm pre-post study to measure the effect of a protein-rich breakfast on autophagic flux in fasting healthy individuals
BackgroundAutophagy is a cellular process that cleanses cells and is particularly important during ageing. Autophagy has been extensively studied in...
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Emerging Therapeutic Targets for Portal Hypertension
Purpose of ReviewPortal hypertension is responsible of the main complications of cirrhosis, which carries a high mortality. Recent treatments have...
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Clearance of inflammatory cytokines in patients with septic acute kidney injury during renal replacement therapy using the EMiC2 filter (Clic-AKI study)
BackgroundThe EMiC2 membrane is a medium cut-off haemofilter (45 kiloDalton). Little is known regarding its efficacy in eliminating medium-sized...
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Ficus deltoidea suppresses endothelial activation, inflammation, monocytes adhesion and oxidative stress via NF-κB and eNOS pathways in stimulated human coronary artery endothelial cells
BackgroundFicus deltoidea (FD) has been shown to have antidiabetic, anti-inflammatory, antinociceptive and antioxidant properties. However, its...
