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Intrapartum Management of Moderate to Severe COVID-19: an Evidence-Based Update
Purpose of ReviewThis review was performed to provide an evidence-based approach to specific intrapartum management considerations for pregnant...
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Moderate evidence exists for four microRNAs as potential biomarkers for tendinopathies and degenerative tendon ruptures at the upper extremity in elderly patients: conclusion of a systematic review with best-evidence synthesis
PurposeThe aim of this systematic review was to investigate tendon-specific microRNAs (miRNAs) as biomarkers for the detection of tendinopathies or...
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Management of Moderate to Severe Plaque Psoriasis with Brodalumab in Daily Practice: Real-World Evidence from the LIBERO Study in the Czech Republic
IntroductionPsoriasis is a chronic, immune-mediated inflammatory skin disease. Despite the availability of several therapies, many patients affected...
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Pharmacokinetics and Tolerability of Zibotentan in Patients with Concurrent Moderate Renal and Moderate Hepatic Impairment
Background and ObjectiveZibotentan, a selective endothelin A receptor antagonist, is in development for chronic liver and kidney disease. The...
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No evidence for effects of low-intensity vestibular noise stimulation on mild-to-moderate gait impairments in patients with Parkinson’s disease
BackgroundGait impairment is a key feature in later stages of Parkinson’s disease (PD), which often responds poorly to pharmacological therapies....
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Treatments for Moderate-to-Severe Alopecia Areata: A Systematic Narrative Review
Treatments for alopecia areata (AA) have traditionally been prescribed off-label, and there has been no universal agreement on how to best manage the...
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A Modified Algorithm-Based Levator Aponeurectomy in Mild to Moderate Congenital Blepharoptosis
BackgroundLevator aponeurectomy is a common operation for mild to moderate blepharoptosis. The accuracy of ptosis correction relied on intraoperative...
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Lebrikizumab for the Treatment of Moderate-to-Severe Atopic Dermatitis
Atopic dermatitis (AD) is a common, heterogeneous, inflammatory skin disorder characterized by chronic or relapsing eczematous lesions with intense...
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Filgotinib for Moderate to Severe Rheumatoid Arthritis: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
The National Institute for Health and Care Excellence (NICE) invited the manufacturer (Gilead) of filgotinib (Jyseleca TM ), as part of the single...
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Moderate alcohol consumption on the risk of stroke in the Million Veteran Program
BackgroundThere is inconsistent evidence on the association of moderate alcohol consumption and stroke risk in the general population and is not well...
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Association between negative life events through mental health and non-suicidal self-injury with young adults: evidence for sex moderate correlation
BackgroundNon-suicidal self-injury (NSSI) has exhibited an increasing trend in recent years and is now globally recognized as a major public health...
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The IBD-FITT study — moderate-intensity exercise for patients with inflammatory bowel disease with moderate disease activity: an open-label randomized controlled trial
BackgroundInflammatory bowel disease (IBD), Crohn’s disease, and ulcerative colitis are chronic autoimmune lifelong diseases with fluctuating...
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Causal relationship between moderate to vigorous physical activity and venous thromboembolism
Previous studies have shown conflicting results about the impact of moderate to vigorous physical activity on the risk of venous thromboembolism...
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Modified Levator Resection Technique for Moderate Congenital Blepharoptosis
BackgroundFor moderate ptosis associated with fair levator function (LF), the levator resection is the most commonly used procedure. However, the...
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Increasing Access to Effective Systemic Treatments in Patients with Moderate-to-Severe Psoriasis: Narrative Review
Psoriasis is a chronic, immune-mediated inflammatory disease with a worldwide prevalence ranging between 0.51 and 11.43%. It results in a large...
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Intranasal analgesia for acute moderate to severe pain in children – a systematic review and meta-analysis
BackgroundChildren in acute pain often receive inadequate pain relief, partly from difficulties administering injectable analgesics. A rapid-acting,...
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Cerebral perfusion is not impaired in persons with moderate obstructive sleep apnoea when awake
PurposeIt is well established that, together with a multitude of other adverse effects on health, severe obstructive sleep apnoea causes reduced...
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Guidelines for Seizure Prophylaxis in Adults Hospitalized with Moderate–Severe Traumatic Brain Injury: A Clinical Practice Guideline for Health Care Professionals from the Neurocritical Care Society
BackgroundThere is practice heterogeneity in the use, type, and duration of prophylactic antiseizure medications (ASMs) in patients with...
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Maintaining moderate versus lower PEEP after cardiac surgery: a propensity-scored matched analysis
BackgroundSetting positive end-expiratory pressure (PEEP) at around 5 cm H 2 O in the early postoperative period seems a common practice for most...
