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Practical guidelines for the treatment of vitiligo with the melanocyte-keratinocyte transplantation procedure
Vitiligo manifests as depigmented macules and patches on the skin and can significantly impact a patient’s quality of life. Despite the availability...
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Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous Inflammation
PurposeAlpha-melanocyte stimulating hormone (α-MSH) is known to have anti-inflammatory effects. However, the anti-inflammatory properties of α-MSH on...
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BMP-2 regulates the expression of myosin Va via smad in melan-a melanocyte
Myosin Va (Myo Va) is one of three protein complexes involved in melanosome transport. In this study, we identified BMP-2 as an up-regulator of Myo...
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Alpha-melanocyte-stimulating hormone during exercise recovery has prognostic value for coronary artery disease
PurposeAlpha-melanocyte-stimulating hormone (alpha-MSH) has proven cardiovascular effects and plays a significant role as an endogenous...
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Digital morphometry and cluster analysis identifies four types of melanocyte during uveal melanoma progression
BackgroundSeveral types of benign and malignant uveal melanocytes have been described based on their histological appearance. However, their...
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Comparison of responses of melanocyte lineages from p75(+) and p75(−) human scalp-derived neural crest stem cells under phototherapy
Phototherapy is an effective therapeutic option in the treatment of vitiligo; however, responses varied among the different types. The underlying...
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Exploring Therapeutic Approaches for Vitiligo: An Inclusive Review from Translational Modalities to Alternative Therapies
Purpose of ReviewThe primary objective of this extensive literature review was to explore emerging therapeutic modalities for Vitiligo, with the aim...
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Lessons Learned from Anatomic Susceptibility in Vitiligo Patients: A Systematic Review
Purpose of ReviewVitiligo is an acquired condition resulting from melanocyte disappearance and clinically manifests as explicit white patches....
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Serum alpha-melanocyte-stimulating hormone (a-MSH), brain-derived neurotrophic factor (BDNF), and agouti-related protein (AGRP) levels in children with Prader-Willi or Bardet-Biedl syndromes
BackgroundAlthough leptin/melanocortin pathway pathologies in hypothalamus are thought to be the main cause of early-onset obesity and hyperphagia in...
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Mucosal Melanoma of Palate: A Case Report with Review of Literature
The World Health Organisation defines mucosal malignant melanoma as a malignant tumour of melanocytes or of melanocyte progenitors. Due to the lack...
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Tacrolimus (FK506) ointment combined with Nb-UVB could activate both hair follicle (HF) and dermal melanocyte precursors in vitiligo: the first histopathological and clinical study
Topical Tacrolimus, especially when combined with Nb-UVB, has been proven clinically to be effective in the treatment of vitiligo. However, no...
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Altered levels of lymphocyte enhancer-binding factor-1 modulates the pigmentation in acral and non-acral lesions of non-segmental vitiligo patients: a follow-up-based study in North India
BackgroundLymphocyte enhancer-binding factor-1 (LEF1) is responsible for melanocyte proliferation, migration and differentiation and its...
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Hair Follicle Melanocytes Initiate Autoimmunity in Alopecia Areata: a Trigger Point
Alopecia areata (AA) is characterized by common non-scarring alopecia due to autoimmune disorders. To date, the specific pathogenesis underlying AA...
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Paeoniflorin regulates RhoA/ROCK1 and Nrf2 pathways in PDLIM1-dependent or independent manners in oxidative stressed melanocytes
BackgroundThe adhesive properties of vitiligo melanocytes have decreased under oxidative stress., cytoskeleton proteins can control cell adhesion....
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A case of choroidal melanocytosis observed by multimodal imaging with laser speckle flowgraphy
BackgroundChoroidal melanocytosis is characterized by congenital diffuse melanin pigmentation with extensive parenchymal infiltration of spindle...
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Clinical Features, Immunopathogenesis, and Therapeutic Strategies in Vitiligo
Vitiligo is an autoimmune disease of the skin characterized by epidermal melanocyte loss resulting in white patches, with an approximate prevalence...
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Update on Melasma—Part I: Pathogenesis
Melasma is a multifactorial dyschromia that results from exposure to external factors (such as solar radiation) and hormonal factors (such as sex...
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Melanoma-derived soluble mediators modulate neutrophil biological properties and the release of neutrophil extracellular traps
Polymorphonuclear neutrophils (PMNs) are the main effector cells in the inflammatory response. The significance of PMN infiltration in the tumor...
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Cerebrolysin induces hair repigmentation associated to MART-1/Melan-A reactivation
Hair graying, a prototypical sign of human aging, is a progressive loss of pigmentation from growing hair shafts caused by disease and as a side...
