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Extra-articular location of the three-dimensional mechanical axis in advanced knee osteoarthritis: an upright computed tomography study
PurposeOne of the most widely used benchmarks of lower-limb alignment is the mechanical axis (MA), which passes through the centers of the femoral...
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Radiologists should use the hip-knee-ankle angle rather than the mechanical axis deviation to describe knee alignment
ObjectivePreoperative and postoperative coronal knee alignment is an important predictor of total knee arthroplasty (TKA) failure. Radiologists often...
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Association of atypical femoral fracture location and lower limb mechanical axis: a computed tomography-based finite element analysis
SummaryAtypical femoral fractures (AFFs) are categorized as low-energy fractures of the femoral shaft or subtrochanteric region. The use of computed...
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Influence of lower-limb mechanical axis on the curative effect of medial high tibial osteotomy for knee osteoarthritis
PurposeTo investigate the effect of the ratio of the medial tibial plateau width to the total tibial plateau width on the therapeutic efficacy of...
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No relevant mechanical leg axis deviation in the frontal and sagittal planes is to be expected after subtrochanteric or supracondylar femoral rotational or derotational osteotomy
PurposeThe purpose of this study was to investigate if one level of corrective femoral osteotomy (subtrochanteric or supracondylar) bears an...
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Functional Outcome of Mechanical Alignment in Total Knee Arthroplasty Surgery: A Short-Term Cohort Study at an Indian Tertiary Care Hospital
BackgroundIn severe arthritis cases, goal of total knee arthroplasty (TKA) management is to attain pain-free joint and restore the overall limb...
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Epigenetic associations in HPA axis genes related to bronchopulmonary dysplasia and antenatal steroids
BackgroundBronchopulmonary dysplasia (BPD), a common morbidity among very preterm infants, is associated with chronic disease and neurodevelopmental...
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Mechanical power made simple: validating a simplified calculation of mechanical power in preterm lungs
BackgroundThe incidence of chronic lung disease is increasing, suggesting a need to explore novel ways to understand ventilator induced lung injury...
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Gut microbiota and type 2 diabetes mellitus: a focus on the gut-brain axis
Type 2 diabetes mellitus (T2DM) has become one of the most serious public healthcare challenges, contributing to increased mortality and disability....
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Gut–liver axis: barriers and functional circuits
The gut and the liver are characterized by mutual interactions between both organs, the microbiome, diet and other environmental factors. The sum of...
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Influence of leg axis alignment on MRI T2* map** of the knee in young professional soccer players
BackgroundInvestigation of the association between leg axis alignment and biochemical MRI in young professional soccer players in order to identify a...
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Quantum mechanical analysis of yttrium-stabilized zirconia and alumina: implications for mechanical performance of esthetic crowns
BackgroundYttrium-stabilized zirconia (YSZ) and alumina are the most commonly used dental esthetic crown materials. This study aimed to provide...
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Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling
The extracellular matrix (ECM) serves as signals that regulate specific cell states in tumor tissues. Increasing evidence suggests that extracellular...
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Comparison of anatomic axes with a navigated functional rotation axis determined by ligament tension for rotational femoral component alignment in cadaver knee arthroplasty
IntroducionThe malimplantation of the total knee arthroplasty (TKA) components is one of the main reasons for revision surgery. For determining the...
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Topic: Nutrition and the Gut-Liver-Brain Axis
The gut-liver brain-axis describes the bidirectional interaction between the gastrointestinal system, the liver, and the central nervous system with...
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Robot-assisted total knee arthroplasty improves mechanical alignment and accuracy of component positioning compared to the conventional technique
PurposeThe purpose of this study was to compare the mechanical axis, accuracy of component positioning, and polyethylene liner thickness between...
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Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx
To date, several molecules have been found to facilitate iron influx, while the types of iron influx channels remain to be elucidated. Here, Piezo1...
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The Sphingosine 1-Phosphate Axis: an Emerging Therapeutic Opportunity for Endometriosis
Endometriosis is a common condition in women of reproductive age, but its current interventions are unsatisfactory. Recent research discovered a...
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Targeting the neutral hip-to-calcaneus axis in kinematically aligned total knee arthroplasty is feasible with fewer alignment outliers for varus osteoarthritic patients
PurposeAssessment of the conventional mechanical axis (MA) (hip-to-talus axis) is reported to result in constitutional varus in the native knee....