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Long-term, low-dose macrolide antibiotic treatment in pediatric chronic airway diseases
AbstractMacrolide antibiotics are one of the most commonly used broad-spectrum antibiotics. They have an inhibitory effect on a variety of...
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Infantile hypertrophic pyloric stenosis: maternal diabetes and perinatal exposure to non-macrolide antibiotics
ObjectiveInfant exposure to macrolide antibiotics is a risk factor for infantile hypertrophic pyloric stenosis (IHPS). The aim of the study was to...
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Efficacy of doxycycline therapy for macrolide-resistant Mycoplasma pneumoniae pneumonia in children at different periods
BackgroundThe prevalence of macrolide-resistant Mycoplasma pneumoniae has increased considerably. Treatment in children has become challenging. This...
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Use of proton pump inhibitors and macrolide antibiotics and risk of acute kidney injury: a self-controlled case series study
BackgroundProton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal disorders such as peptic ulcer disease and dyspepsia....
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Impact of macrolide treatment on long-term mortality in patients admitted to the ICU due to CAP: a targeted maximum likelihood estimation and survival analysis
IntroductionPatients with community-acquired pneumonia (CAP) admitted to the intensive care unit (ICU) have high mortality rates during the acute...
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Cavitatory necrotising pneumonia with extrapulmonary multi-systemic involvement — a rare presentation of macrolide-resistant Mycoplasma pneumoniae
BackgroundMycoplasma pneumoniae is one of the leading causes of community-acquired pneumonia. Due to its microbiological variation, clinical...
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Variables associated with antibiotic treatment tolerance in patients with Mycobacterium avium complex pulmonary disease
BackgroundTreatment of Mycobacterium avium complex pulmonary disease (MAC-PD) involves prolonged courses of multiple antibiotics that are variably...
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Early discontinuation of combination antibiotic therapy in severe community-acquired pneumonia: a retrospective cohort study
BackgroundSevere community-acquired pneumonia (SCAP) is commonly treated with an empiric combination therapy, including a macrolide, or a quinolone...
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Molecular beacon based real-time PCR p1 gene genoty**, macrolide resistance mutation detection and clinical characteristics analysis of Mycoplasma pneumoniae infections in children
BackgroundMycoplasma pneumoniae can be divided into different subtypes on the basis of the sequence differences of adhesive protein P1, but the...
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Quality of antibiotic prescribing for pediatric community-acquired Pneumonia in outpatient care
BackgroundAntibiotics remain the primary treatment for community acquired pneumonia (CAP), however rising rates of antimicrobial resistance may...
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Clinical algorithm reduces antibiotic use among children presenting with respiratory symptoms to hospital in central Vietnam
ObjectiveTo assess the safety and utility of a pragmatic clinical algorithm to guide rational antibiotic use in children presenting with respiratory...
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Doxycycline vs. macrolides in combination with a β-lactam antibiotic for the treatment of community-acquired pneumonia in inpatients
BackgroundHospitalized patients with non-severe community-acquired pneumonia (CAP) are treated with a β-lactam plus either a macrolide or...
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Evaluation of treatment with two weeks of doxycycline on macrolide-resistant strains of Mycoplasma genitalium: a retrospective observational study
BackgroundIncreasing macrolide resistance makes treatment of Mycoplasma genitalium infections challenging. The second-line treatment is...
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Physicians’ irrational attitudes on the antibiotic prescribing for the treatment of COVID-19 in Turkey: A multicenter survey
BackgroundThe inappropriate and excessive use of antibiotics during the coronavirus pandemic has become an important issue.
Objective ...
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Genome analysis of Streptococcus spp. isolates from animals in pre-antibiotic era with respect to antibiotic susceptibility and virulence gene profiles
Lyophilized Streptococcus spp. isolates ( n = 50) from animal samples submitted to the diagnostic laboratory at the University of Connecticut in the...
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Antibiotic prescribing for children with upper respiratory tract infection: a Finnish nationwide 7-year observational study
Upper respiratory tract infection (URTI) is a self-limiting viral infection and should not be treated with antibiotics. The aim was to evaluate...
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How Streptococcus suis escapes antibiotic treatments
Streptococcus suis is a zoonotic agent that causes sepsis and meningitis in pigs and humans. S. suis infections are responsible for large economic...
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Zoonotic and antibiotic-resistant Campylobacter: a view through the One Health lens
As a pathogen of a major public health concern with animal health importance, Campylobacter constitutes a clear and present threat to One Health....
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Efficacy of tetracyclines and fluoroquinolones for the treatment of macrolide-refractory Mycoplasma pneumoniae pneumonia in children: a systematic review and meta-analysis
BackgroundMycoplasma pneumoniae is a common pathogen that causes community-acquired pneumonia in school-age children. Macrolides are considered a...
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Empirical antibiotic treatment for community-acquired pneumonia and accuracy for Legionella pneumophila, Mycoplasma pneumoniae, and Clamydophila pneumoniae: a descriptive cross-sectional study of adult patients in the emergency department
BackgroundMany factors determine empirical antibiotic treatment of community-acquired pneumonia (CAP). We aimed to describe the empirical antibiotic...
