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The role of M1/M2 macrophage polarization in primary Sjogren’s syndrome
BackgroundThe purpose of this study was to investigate the role of macrophage polarization in the pathogenesis of primary Sjogren’s syndrome (pSS).
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Macrophage polarization toward M1 phenotype in T cell transfer colitis model
BackgroundT cell transfer colitis model is often used to study the CD4 + T cell functions in the intestine. However, the specific roles of...
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Acetylcholine muscarinic M1 receptors in the rodent prefrontal cortex modulate cognitive abilities to establish social hierarchy
In most social species, the attainment of social dominance is strongly affected by personality traits. Dominant individuals show better cognitive...
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Heterogeneity of adipose tissue-resident macrophages-beyond M1/M2 paradigm
Adipose tissue-resident macrophages (ATMs) are reported to be important for maintaining adipose tissue remodeling and homeostasis. ATMs were...
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Determination of M1/M2 Macrophage Polarization in Ipsilateral and Contralateral Rat Testis Tissue Following Unilateral Torsion/Detorsion
The present study investigates the changes in M1/M2 macrophage polarization resulting from unilateral testicular torsion in the bilateral testis. The...
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SP1 transcriptionally activates HTR2B to aggravate traumatic spinal cord injury by shifting microglial M1/M2 polarization
BackgroundSpinal cord injury (SCI) can result in structural and functional damage to the spinal cord, which may lead to loss of limb movement and...
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Codonopsis pilosula-derived glycopeptide dCP1 promotes the polarization of tumor-associated macrophage from M2-like to M1 phenotype
The majority of the immune cell population in the tumor microenvironment (TME) consists of tumor-associated macrophages (TAM), which are the main...
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Correlation of bilateral M1 hand area excitability and overall functional recovery after spinal cord injury: protocol for a prospective cohort study
BackgroundAfter spinal cord injury (SCI), a large number of survivors suffer from severe motor dysfunction (MD). Although the injury site is in the...
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Distance to thrombus, ischemic lesion volume and clinical outcome after thrombectomy for M1 middle cerebral artery occlusion
BackgroundStroke resulting from occlusion of the middle cerebral artery (MCA) can have devastating consequences, potentially leading to a loss of...
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Development and application of a fully automatic multi-function cassette module Mortenon M1 for radiopharmaceutical synthesis
IntroductionFunctions of existing automatic module systems for synthesis of radiopharmaceuticals mainly focus on the radiolabeling of small...
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Melatonin improves influenza virus infection-induced acute exacerbation of COPD by suppressing macrophage M1 polarization and apoptosis
BackgroundInfluenza A viruses (IAV) are extremely common respiratory viruses for the acute exacerbation of chronic obstructive pulmonary disease...
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Yangqing Chenfei formula alleviates silica-induced pulmonary inflammation in rats by inhibiting macrophage M1 polarization
BackgroundYangqing Chenfei formula (YCF) is a traditional Chinese medicine formula for early-stage silicosis. However, the therapeutic mechanism is...
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Hyperthermia promotes M1 polarization of macrophages via exosome-mediated HSPB8 transfer in triple negative breast cancer
PurposeTo investigate the mechanism underlying the modulation of M1 macrophage polarization by exosomes released from hyperthermia-treated...
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Plasma Exosomes Aggravate Acute Pancreatitis by Promoting M1 Polarization of Adipose Tissue Macrophages in Obesity-Related Severe Acute Pancreatitis
Background and AimsObesity may be a risk factor for severe acute pancreatitis (SAP). However, its precise mechanism is not yet fully understood.
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Macrophage polarization toward M1 phenotype through NF-κB signaling in patients with Behçet’s disease
BackgroundMacrophages are key innate immune cells implicated in the pathogenesis of Behçet’s disease (BD), and macrophage polarization plays a...
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Photobiomodulation activates undifferentiated macrophages and promotes M1/M2 macrophage polarization via PI3K/AKT/mTOR signaling pathway
Macrophages are the main mediators of the inflammatory response and play a major role in the onset and maintenance of periodontitis. Studies revealed...
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CCL3 aggravates intestinal damage in NEC by promoting macrophage chemotaxis and M1 macrophage polarization
BackgroundNEC is a life-threatening gastrointestinal disease in neonates, the pathogenesis of which remains poorly understood.
Methods ...
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Successful mechanical thrombectomy in acute bilateral M1 middle cerebral artery occlusion: a case report and literature review
BackgroundAcute bilateral occlusion of the middle cerebral artery (MCA) is a very rare condition, and most cases are accompanied by a poor prognosis....
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Exogenous IL-25 ameliorates airway neutrophilia via suppressing macrophage M1 polarization and the expression of IL-12 and IL-23 in asthma
BackgroundSevere asthma is associated with substantial mortality and has unmet therapeutic need. A subset of severe asthma is characterized by...
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Long non-coding RNA MM2P suppresses M1-polarized macrophages-mediated excessive inflammation to prevent sodium taurocholate-induced acute pancreatitis by blocking SHP2-mediated STAT3 dephosphorylation
M1 macrophage-mediated excessive inflammatory response plays a key role in the onset and progression of acute pancreatitis (AP), and this study aimed...
