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Design of live-attenuated animal vaccines based on pseudorabies virus platform
Pseudorabies virus (PRV) is a double-stranded DNA virus with a genome approximating 150 kb in size. PRV contains many non-essential genes that can be...
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Trauma surgical simulation: discussing the replacement of live animals used as human patient simulators
BackgroundDespite advances in simulator technology, live anaesthetised animals continue to be used as human patient simulators for medical...
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Transfer of virtual reality endoscopy training to live animal colonoscopy: a randomized control trial of proficiency vs. repetition-based training
BackgroundLow first-time pass rates of the Fundamentals of Endoscopic Surgery (FES) exam stimulated development of virtual reality (VR) simulation...
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Zebrafish live imaging: a strong weapon in anticancer drug discovery and development
Develo** anticancer drugs is a complex and time-consuming process. The inability of current laboratory models to reflect important aspects of the...
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Post-mortem freshwater animal predation—a case report
BackgroundPost-mortem animal predation affects human corpses in various ways. Lesions are a characteristic of the type of terrestrial or aquatic...
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Relationship between dietary live microbe intake and the prevalence of COPD in adults: a cross-sectional study of NHANES 2013–2018
ObjectiveTo explore the potential association between dietary live microbes and the prevalence of Chronic Obstructive Pulmonary Diseases (COPD).
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Wild boar behaviour during live-trap capture in a corral-style trap: implications for animal welfare
BackgroundWildlife traps are used in many countries without evaluation of their effect on animal welfare. Trap-capture of wild animals should...
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Chlamydia psittaci detected at a live poultry wholesale market in central China
BackgroundWe investigated the presence of Chlamydia psittaci in poultry and the environment in live poultry wholesale markets in Changsha during...
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Public perspectives on strays and companion animal management in Malaysia
Strays and companion animal management is a sensitive issue in Malaysia that incites solid and conflicting views. Through structured questionnaires...
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Will we ever eradicate animal tuberculosis?
Two characteristics of the Mycobacterium tuberculosis complex (MTC) are particularly relevant for tuberculosis (TB) epidemiology and control, namely...
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Age-related increase in live-birth rates of first frozen thaw embryo versus first fresh transfer in initial assisted reproductive technology cycles without PGT
BackgroundThe landscape of assisted reproductive technology (ART) has seen a significant shift towards frozen-thawed embryo transfers (FET) over...
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Evaluation of live birth rates and perinatal outcomes following two sequential vitrification/warming events at the zygote and blastocyst stages
PurposeTo study the outcome of sequential cryopreservation-thawing of zygotes followed by the cryopreservation-thawing of blastocysts in the course...
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Antigen epitopes of animal coronaviruses: a mini-review
Coronaviruses are widespread in nature and can infect mammals and poultry, making them a public health concern. Globally, prevention and control of...
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Hampshire Sheep as a Large-Animal Model for Cochlear Implantation
BackgroundSheep have been proposed as a large-animal model for studying cochlear implantation. However, prior sheep studies report that the facial...
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Stem cell therapy for premature ovarian insufficiency: a systematic review and meta-analysis of animal and clinical studies
PurposeThe aim of this systematic review and meta-analysis is to evaluate the efficacy of stem cell therapy in mouse models of POI and patients with...
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Transmission patterns of multiple strains producing New Delhi metallo-β-lactamase variants among animals and the environment in live poultry markets
The widespread transmission of bla NDM among livestock and the live poultry industry attracts considerable public attention. However, studies have not...
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A novel live attenuated duck Tembusu virus vaccine targeting N7 methyltransferase protects ducklings against pathogenic strains
Duck Tembusu virus (DTMUV), an emerging pathogenic flavivirus, causes markedly decreased egg production in laying duck and neurological dysfunction...
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Animal models of acute exacerbation of pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive scarring interstitial lung disease with an unknown cause. Some patients may experience...
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In vivo detection of hydrogen sulfide in the brain of live mouse: application in neuroinflammation models
PurposeHydrogen sulfide (H 2 S) plays important roles in brain pathophysiology. However, nuclear imaging probes for the in vivo detection of brain H 2 S...
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Establishment and identification of an animal model of Hirschsprung disease in suckling mice
BackgroundHirschsprung disease (HSCR) is a congenital intestinal malformation. Previous HSCR animal model needs invasive operation on adult animal....
