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Impact of Istradefylline on Levodopa Dose Escalation in Parkinson’s Disease: ISTRA ADJUST PD Study, a Multicenter, Open-Label, Randomized, Parallel-Group Controlled Study
IntroductionA higher levodopa dose is a risk factor for motor complications in Parkinson’s disease (PD). Istradefylline (IST) is used as adjunctive...
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High-dose versus low-dose inhaled levodopa (CVT-301) in patients with Parkinson disease for the treatment of OFF episodes: a meta-analysis of randomized controlled trials
BackgroundLevodopa is the most commonly used first-line drug for Parkinson’s disease. However, during the period of medication, the generation of...
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An updated calculator for determining levodopa-equivalent dose
Calculation of levodopa-equivalent dose in Parkinson’s disease has become common in research, but is also a useful tool in clinical practice,...
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Levodopa may modulate specific speech impairment in Parkinson's disease: an fMRI study
Hypokinetic dysarthria (HD) is a difficult-to-treat symptom affecting quality of life in patients with Parkinson’s disease (PD). Levodopa may...
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Inhaled levodopa for threatening impending OFF episodes in managing Parkinson’s disease
Parkinson’s disease (PD) is a neurodegenerative disorder that leads to the degeneration of dopaminergic neurons resulting in a widespread pathology...
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Subcutaneous Levodopa: A New Engine for the Vintage Molecule
The management of Parkinson’s disease (PD) continues to evolve with advancements in non-oral levodopa-based therapies aiming to provide continuous...
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Evaluating the impact of adjunctive istradefylline on the cumulative dose of levodopa-containing medications in Parkinson’s disease: study protocol for the ISTRA ADJUST PD randomized, controlled study
BackgroundLevodopa remains the most effective symptomatic treatment for Parkinson’s disease (PD) more than 50 years after its clinical introduction....
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Apprends-moi l'art des petits pas: Levodopa, Carbidopa Intestinal Gel plus Entacapone
We are always looking for the big breakthrough, ideally a cure for our advanced Parkinson’s disease (aPD) patients. As long as this does not happen...
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Effect of levodopa on postural blood pressure changes in Parkinson disease: a randomized crossover study
PurposeWe investigated the effect of levodopa on postural blood pressure changes in individuals with Parkinson disease (PD) with (PD +OH ) and without...
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The effect of levodopa treatment on vascular endothelial function in Parkinson’s disease
ObjectiveThere has been increasing awareness that micro-vascular alteration or vascular inflammation has been associated with levodopa-induced...
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A video-atlas of levodopa-induced dyskinesia in Parkinson’s disease: terminology matters
Dyskinesia is a common complication of long-term levodopa therapy in patients with Parkinson’s disease (PD), which often worsens the quality of life....
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Unlocking the potential: T1-weighed MRI as a powerful predictor of levodopa response in Parkinson’s disease
BackgroundThe efficacy of levodopa, the most crucial metric for Parkinson’s disease diagnosis and treatment, is traditionally gauged through the...
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Kinect-based objective assessment of the acute levodopa challenge test in parkinsonism: a feasibility study
IntroductionThe acute levodopa challenge test (ALCT) is an important and valuable examination but there are still some shortcomings with it. We aimed...
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Characteristics of behavioural addiction in Parkinson’s disease patients with self-reported impulse control disorder and controls matched for levodopa equivalent dose: a matched case–control study
Impulse control disorders (ICD) in Parkinson’s disease (PD) frequently occur, not always as a direct consequence of dopaminergic medication. This...
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Adopting the Rumsfeld approach to understanding the action of levodopa and apomorphine in Parkinson’s disease
Dopaminergic therapies dominate the treatment of the motor and non-motor symptoms of Parkinson’s disease (PD) but there have been no major advances...