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Diagnostic and Therapeutic Updates in Leptomeningeal Disease
Purpose of ReviewLeptomeningeal disease (LMD) is a devastating complication of advanced metastatic cancer associated with a poor prognosis and...
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Systemic Treatment for Brain Metastasis and Leptomeningeal Disease in Breast Cancer Patients
Purpose of ReviewBreast cancer with brain metastasis (BCBM) and leptomeningeal disease (LMD) are important clinical problems. Traditionally, patients...
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Prognostic value of cerebrospinal fluid tumor cell count in leptomeningeal disease from solid tumors
PurposeTreatment decisions for leptomeningeal disease (LMD) rely on patient risk stratification, since clinicians lack objective prognostic tools....
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The Spectrum of Headache in Leptomeningeal Metastases: A Comprehensive Review with Clinical Management Guidelines
Purpose of ReviewHeadaches are a common, oftentimes debilitating symptom in patients with leptomeningeal metastases.
Recent FindingsThe third...
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Intrathecal chemotherapy for leptomeningeal disease in high-grade gliomas: a systematic review
BackgroundLeptomeningeal disease (LMD) secondary to high grade glioma (HGG), such as glioblastoma (GBM), are characterized by the spread of tumor...
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Understanding diffuse leptomeningeal glioneuronal tumors
IntoductionDiffuse leptomeningeal glioneuronal tumors (DLGNTs) pose a rare and challenging entity within pediatric central nervous system neoplasms....
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EGFR-mutated non-small lung cancer brain metastases and radiosurgery outcomes with a focus on leptomeningeal disease
PurposePatients with EGFR-mutated NSCLC represent a unique subset of lung cancer patients with distinct clinical and molecular...
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Hemangioblastoma with late leptomeningeal metastasis: a case report
BackgroundHemangioblastoma of the central nervous system is an uncommon benign neoplasm, with about 25% of cases in patients with von Hippel–Lindau...
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Leveraging Molecular and Immune-Based Therapies in Leptomeningeal Metastases
Leptomeningeal metastases represent an aggressive stage of cancer with few durable treatment options. Improved understanding of cancer biology,...
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Demographic and clinical characteristics of patients with metastatic breast cancer and leptomeningeal disease: a single center retrospective cohort study
PurposeLeptomeningeal disease (LMD) is a devastating complication of metastatic breast cancer (MBC). It is critical to better understand the risk...
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DEGRO guideline for personalized radiotherapy of brain metastases and leptomeningeal carcinomatosis in patients with breast cancer
PurposeThe aim of this review was to evaluate the existing evidence for radiotherapy for brain metastases in breast cancer patients and provide...
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Advances in the Diagnosis and Treatment of Leptomeningeal Disease
Purpose of ReviewLeptomeningeal disease (LMD) is a rare, late complication of systemic cancer and is associated with significant neurological...
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Systemic Therapy for Melanoma Brain and Leptomeningeal Metastases
Melanoma has a high propensity to metastasize to the brain which portends a poorer prognosis. With advanced radiation techniques and targeted...
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Leptomeningeal spread in high-grade gliomas: Is surgery or adjuvant therapy after leptomeningeal spread associated with survival benefit?
PurposeThis study aimed to identify prognostic factors associated with survival in patients with high-grade glioma (HGG) after leptomeningeal spread...
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Evolving management of HER2+ breast cancer brain metastases and leptomeningeal disease
Patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer are at a particularly high risk of breast cancer brain...
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Comparison of the diagnostic significance of cerebrospinal fluid metagenomic next-generation sequencing copy number variation analysis and cytology in leptomeningeal malignancy
BackgroundDiagnosis and monitoring of leptomeningeal malignancy remain challenging, and are usually based on neurological, radiological,...
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Postoperative disappearance of leptomeningeal enhancement around the brainstem in glioblastoma
PurposeLeptomeningeal enhancement (LME) suggests leptomeningeal dissemination (LMD) of tumor cells, which is a complication of end-stage...
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Liquid biopsy in the setting of leptomeningeal metastases: a systematic review and meta-analysis
PurposeThe blood-brain barrier can prevent circulating tumor DNA (ctDNA) derived from the central nervous system from entering the blood making it...
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ICAM2 initiates trans-blood-CSF barrier migration and stemness properties in leptomeningeal metastasis of triple-negative breast cancer
Leptomeningeal metastasis (LM) occurs when tumor cells spread to the leptomeningeal space surrounding the brain and the spinal cord, thereby causing...
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Prognostic impact of clinical and radiological factors on leptomeningeal metastasis from solid cancers
PurposeThe number of leptomeningeal metastasis (LM) patients has increased in recent years, as the cancer survival rates increased. An optimal...
