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CLIP170 inhibits the metastasis and EMT of papillary thyroid cancer through the TGF-β pathway
Metastasis poses a significant challenge in combating tumors. Even in papillary thyroid cancer (PTC), which typically exhibits a favorable prognosis,...
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MGMT-inhibitor in combination with TGF-βRI inhibitor or CDK 4/6 inhibitor increases temozolomide sensitivity in temozolomide-resistant glioblastoma cells
BackgroundGlioblastoma (GB) remains an incurable and deadly brain malignancy that often proves resistant to upfront treatment with temozolomide....
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The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses
Prostate cancer (PCa), the second leading cause of death in American men, includes distinct genetic subtypes with distinct therapeutic...
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A matter of differentiation: equine enteroids as a model for the in vivo intestinal epithelium
Epithelial damage due to gastrointestinal disorders frequently causes severe disease in horses. To study the underlying pathophysiological processes,...
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Upregulated TGF-β1 contributes to hyperglycaemia in type 2 diabetes by potentiating glucagon signalling
Aims/hypothesisGlucagon-stimulated hepatic gluconeogenesis contributes to endogenous glucose production during fasting. Recent studies suggest that...
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BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer
Treatment of patients with triple-negative breast cancer (TNBC) has been challenging due to a lack of well-defined molecular targets. The...
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Radiosensitizing effect of galunisertib, a TGF-ß receptor I inhibitor, on head and neck squamous cell carcinoma in vitro
Background . Resistance to radiation therapy poses a major clinical problem for patients suffering from head and neck squamous cell carcinoma (HNSCC)....
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GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cell carcinoma
Treating patients with esophageal squamous cell carcinoma (ESCC) is challenging due to the high chemoresistance. Growth differentiation factor 15...
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Intestinal organoids in farm animals
In livestock species, the monolayer of epithelial cells covering the digestive mucosa plays an essential role for nutrition and gut barrier function....
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Culture of equine intestinal epithelial stem cells after delayed tissue storage for future applications
BackgroundEquine intestinal epithelial stem cells (ISCs) serve as potential targets to treat horses with severe intestinal injury. The ability to...
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EMT-induced immune evasion: connecting the dots from mechanisms to therapy
Epithelial–mesenchymal transition (EMT) is a dynamic program crucial for organismal development and tissue regeneration. Unfortunately, this program...
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Porcine small intestinal organoids as a model to explore ETEC–host interactions in the gut
Small intestinal organoids, or enteroids, represent a valuable model to study host–pathogen interactions at the intestinal epithelial surface. Much...
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Stem cell therapy for hepatocellular carcinoma and end-stage liver disease
Hepatocellular carcinoma (HCC) is a major health problem worldwide, especially for patients who are suffering from end-stage liver disease (ESLD)....
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Establishment of bovine 3D enteroid-derived 2D monolayers
Three-dimensional (3D) intestinal enteroids are powerful in vitro models for studying intestinal biology. However, due to their closed structure...
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CDCA5 promoted cell invasion and migration by activating TGF-β1 pathway in human ovarian cancer cells
BackgroundThe gene cell division cycle associated 5 (CDCA5), also called sororin, has oncogenic characteristics and is upregulated in various...
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Transcription factor YY1 mediates epithelial–mesenchymal transition through the TGFβ signaling pathway in bladder cancer
Bladder cancer is one of the most aggressive urothelial tumors. Previous studies have suggested that epithelial–mesenchymal transition (EMT)...
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Targeting TGFβ signal transduction for cancer therapy
Transforming growth factor-β (TGFβ) family members are structurally and functionally related cytokines that have diverse effects on the regulation of...
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A Review of Persistent Post-COVID Syndrome (PPCS)
Persistent post-COVID syndrome, also referred to as long COVID , is a pathologic entity, which involves persistent physical, medical, and cognitive...
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Molecular classification of hepatocellular carcinoma: prognostic importance and clinical applications
Hepatocellular carcinoma (HCC) is a lethal human malignancy with a very low overall and long-term survival rate. Poor prognostic outcomes are...
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Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies
Despite the success of targeted therapies in cancer treatment, therapy-induced resistance remains a major obstacle to a complete cure. Tumor cells...
