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Inhibitory receptors for HLA class I as immune checkpoints for natural killer cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy
Natural killer (NK) cells mediate potent anti-tumor responses, which makes them attractive targets for immunotherapy. The anti-tumor response of...
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Natural killer cell immunotherapy in glioblastoma
Glioblastoma (GBM) is one of the most difficult cancers to treat because GBM has the high therapeutic resistance. Recently, immunotherapies for GBM...
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Association of the killer immunoglobulin-like receptor genes KIR2DS1 and KIR2DS4 with pediatric autoimmune hepatitis type I in Egypt
BackgroundKiller cell immunoglobulin-like receptors (KIR) are considered to be the key receptors that control the development and function of human...
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Evolution of natural killer cell-targeted therapy for acute myeloid leukemia
In hematologic oncology, acute myeloid leukemia (AML) presents a significant challenge due to its complex genetic landscape and resistance to...
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Killer cell immunoglobulin receptor diversity and its relevance in the human host’s response to HIV infection in African populations
Host response to the human immune deficiency virus (HIV) involves both the innate and adaptive immune systems. As part of the innate immune system,...
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Killer immunoglobulin-like receptor 2DS5 is associated with recovery from coronavirus disease 2019
BackgroundDespite numerous advances in the identification of risk factors for the development of severe coronavirus disease 2019 (COVID-19), factors...
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Improved outcomes of single-unit cord blood transplantation for acute myeloid leukemia by killer immunoglobulin-like receptor 2DL1-ligand mismatch
The impact of the killer immunoglobulin-like receptor (KIR)-ligand mismatch between donor and recipient in hematopoietic stem cell transplantation is...
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Altered effect of killer immunoglobulin-like receptor–ligand mismatch by graft versus host disease prophylaxis in cord blood transplantation
The role of killer immunoglobulin-like receptor–ligand mismatch (KIR–ligand mismatch) between donors and recipients undergoing cord blood...
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Reduced leukemia relapse through cytomegalovirus reactivation in killer cell immunoglobulin-like receptor-ligand-mismatched cord blood transplantation
Cytomegalovirus (CMV) reactivation in cord blood transplantation (CBT) may result in the proliferation and maturation of natural killer (NK) cells....
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Immune profiling of patients with extranodal natural killer/T cell lymphoma treated with daratumumab
Natural killer/T cell lymphoma (NKTCL) is a highly aggressive, heterogeneous non-Hodgkin lymphoma resulting from malignant proliferation of cytotoxic...
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Exploring Natural Killer Cell Testing in Embryo Implantation and Reproductive Failure: An Overview of Techniques and Controversies
The blastocyst nidation is the most crucial stage to a successful pregnancy, as the white cells work to promote a favorable endometrial...
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Targeting natural killer cells: from basic biology to clinical application in hematologic malignancies
Natural killer (NK) cell belongs to innate lymphoid cell family that contributes to host immunosurveillance and defense without pre-immunization....
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Analysis of the expression and prognosis for leukocyte immunoglobulin-like receptor subfamily B in human liver cancer
BackgroundLeukocyte immunoglobulin-like receptor subfamily B (LILRB), including 5 subtypes, is a group of inhibitory receptors in the immune system....
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Reactivation of natural killer cells with monoclonal antibodies in the microenvironment of malignant neoplasms
Natural killer cells are critical players in the antitumor immune response due to their ability to destroy target cells through cytotoxic activity...
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A pilot study of cord blood-derived natural killer cells as maintenance therapy after autologous hematopoietic stem cell transplantation
Natural killer (NK) cell based immunotherapy is an emerging strategy in hematologic malignancies because allogeneic NK cells can provide potent...
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Natural killer cell homing and trafficking in tissues and tumors: from biology to application
Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense against cancer. Although some evidence shows that NK...
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Programmable synthetic receptors: the next-generation of cell and gene therapies
Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat diseases. However, concerns over the safety and efficacy...
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Phenotypic and functional characterisation of locally produced natural killer cells ex vivo expanded with the K562-41BBL-mbIL21 cell line
We characterised the expansion, phenotype and functional activity of natural killer (NK) cells obtained for a clinical trial. Nineteen expansion...
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Negligible role of TRAIL death receptors in cell death upon endoplasmic reticulum stress in B-cell malignancies
Impairments in protein folding in the endoplasmic reticulum (ER) lead to a condition called ER stress, which can trigger apoptosis via the...
