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1. KLF4 Induces Colorectal Cancer by Promoting EMT via STAT3 Activation

   Objective

   Krüppel-like factor 4 (KLF4) has been demonstrated to exert a pro-carcinogenic effect in solid tissues. However, the precise biological...

   Lebin Yuan, Yanqiu Meng, Jiajia **ang in Digestive Diseases and Sciences

   Article 30 May 2024
   

2. KLF4 Inhibits the Activation of Human Hepatic Stellate Cell In Vitro

   Objective

   Hepatic stellate cells (HSCs) play a crucial role in liver fibrosis. Early-stage liver fibrosis is reversible and intimately associated with...

   **ng-yu Yang, Zhe Chen, ... Hai Zheng in Current Medical Science

   Article 24 May 2024

3. Role of lipid metabolism gene KLF4 in osteoarthritis

   Introduction

   Osteoarthritis (OA) is a common degenerative disease of joints, which can appear in almost any joint of the body. Therefore, the...

   Kaibo Hu, Yuan Shu, ... Liang Hao in Clinical Rheumatology

   Article 23 August 2023
   

4. Divergent Roles of KLF4 During Primordial Germ Cell Fate Induction from Human Embryonic Stem Cells

   As a core transcriptional factor regulating pluripotency, Krüppel-like factor 4 (KLF4) has gained much attention in the field of stem cells during...

   Fang Fang, Zili Li, ... **ao Wang in Reproductive Sciences

   Article 26 October 2023
   

5. Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia

   TAL1 is one of the most frequently dysregulated genes in T-ALL and is overexpressed in about 50% of T-ALL cases. One of the molecular mechanisms of TAL1...

   Mina Noura, Hidemasa Matsuo, ... Fumihiko Hayakawa in Oncogene

   Article 15 December 2023
   

6. CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ

   Dysregulated lineage commitment of mesenchymal stem cells (MSCs) contributes to impaired bone formation and an imbalance between adipogenesis and...

   Ruiqi Yu, Hong Han, ... Yaoqin Gong in Bone Research

   Article Open access 02 June 2023
   

7. Cardiac Fibroblast Activation Induced by Oxygen–Glucose Deprivation Depends on the HIF-1α/miR-212-5p/KLF4 Pathway

   It is widely accepted that miRNAs play an important role in the pathogenesis of myocardial fibrosis. This study aimed to identify a new pathway of...

   Hongbing Li, Chenxing Li, ... Tao Chen in Journal of Cardiovascular Translational Research

   Article 07 June 2023
   

8. METTL3-mediated N⁶-methyladenosine modification of STAT5A promotes gastric cancer progression by regulating KLF4

   N ⁶ -methyladenosine (m ⁶ A) is the predominant post-transcriptional RNA modification in eukaryotes and plays a pivotal regulatory role in various...

   Yichen Zang, Zhuangfei Tian, ... Zhifang Liu in Oncogene

   Article Open access 15 June 2024
   

9. MiR-449a downregulation alleviates the progression of renal interstitial fibrosis by mediating the KLF4/MFN2 axis

   Background

   Renal interstitial fibrosis (RIF) seriously threatens the health of individuals. MiRNAs regulate the progression of fibrosis. Nevertheless,...

   **ang-Dong Fang, Jia-Ke He, ... ** Li in International Urology and Nephrology

   Article 12 February 2023
   

10. Expression of stem cell markers SALL4, LIN28A, and KLF4 in ameloblastoma

    Background

    Ameloblastoma (AME) is a benign odontogenic tumour of epithelial origin characterised by slow but aggressive growth, infiltration, and...

    Rafaela de Albuquerque Dias, Karolyny Martins Balbinot, ... João de Jesus Viana Pinheiro in Diagnostic Pathology

    Article Open access 09 August 2023
    

11. GTSE1 promotes tumor growth and metastasis by attenuating of KLF4 expression in clear cell renal cell carcinoma

    Clear cell renal cell carcinoma (ccRCC) is one of the most common malignant tumors and is characterized by a poor prognosis. Although G2- and S...

    Weihao Chen, Hanfeng Wang, ... Xu Zhang in Laboratory Investigation

    Article 18 May 2022
    

12. Depletion of microRNA-92a Enhances the Role of Sevoflurane Treatment in Reducing Myocardial Ischemia–Reperfusion Injury by Upregulating KLF4

    Objective

    As some articles have highlighted the role of microRNA-92a (miR-92a) in myocardial ischemia–reperfusion injury (MI/RI), this article aimed...

    Qianfu Wu, Haihui Wang, ... Guoliang Yan in Cardiovascular Drugs and Therapy

    Article 16 February 2022
    

13. The Notch pathway regulates KLF4 in podocyte injury induced by high glucose

    Background

    Diabetic nephropathy (DN) is a common complication of diabetes. The Notch pathway plays an important role in podocyte injury and decreases...

    Min Yao, **aomei Wang, ... Feng Gao in International Journal of Diabetes in Develo** Countries

    Article 12 August 2021
    

14. The Role of Krüppel-like Factor 4 (KLF4) Gene in Breast Cancer Tissue Samples: A Systematic Review and Meta-analysis

    Background

    Breast cancer is the most common cancer and the primary cause of mortality due to cancer in female around the World. As a result, the aim...

    Nader Salari, Shabnam Rasoulpoor, ... Masoud Mohammadi in Indian Journal of Gynecologic Oncology

    Article 20 January 2022
    

15. Single-cell DNA sequencing reveals order of mutational acquisition in TRAF7/AKT1 and TRAF7/KLF4 mutant meningiomas

    Helin Dogan, Christina Blume, ... Felix Sahm in Acta Neuropathologica

    Article Open access 19 August 2022
    

16. miR-484 suppresses endocrine therapy-resistant cells by inhibiting KLF4-induced cancer stem cells in estrogen receptor-positive cancers

    Endocrine therapy (mainly anti-estrogen therapy) is the mainstay of treatment for estrogen receptor (ER) positive breast cancer (BCa). However,...

    Yulei Wei, Hong Li, Quanxin Qu in Breast Cancer

    Article 31 August 2020
    

17. Electroacupuncture Promotes Angiogenesis in Mice with Cerebral Ischemia by Inhibiting miR-7

    Objective

    To observe the angiogenesis effect of electroacupuncture (EA) at Shuigou acupoint (GV 26) in the treatment of cerebral ischemia, and explore...

    Qian Yu, Shi Shu, ... Shuang Zhou in Chinese Journal of Integrative Medicine

    Article 27 March 2024

18. Involvement of miRNA-34a regulated Krüppel-like factor 4 expression in hyperoxia-induced senescence in lung epithelial cells

    Background

    Premature infants, subjected to supplemental oxygen and mechanical ventilation, may develop bronchopulmonary dysplasia, a chronic lung...

    Hajime Maeda, Hongwei Yao, ... Phyllis A. Dennery in Respiratory Research

    Article Open access 10 December 2022
    

19. MicroRNA-146a Promotes Embryonic Stem Cell Differentiation towards Vascular Smooth Muscle Cells through Regulation of Kruppel-like Factor 4

    Objective

    Vascular smooth muscle cell (VSMC) differentiation from stem cells is one source of the increasing number of VSMCs that are involved in...

    Qing Zhang, Rong-rong Pan, ... Yu-miao Wei in Current Medical Science

    Article Open access 19 April 2023

20. Reactivation of super-enhancers by KLF4 in human Head and Neck Squamous Cell Carcinoma

    Head and neck squamous cell carcinoma (HNSCC) is a disease of significant morbidity and mortality and rarely diagnosed in early stages. Despite...

    Maria Tsompana, Christian Gluck, ... Michael J. Buck in Oncogene

    Article 02 September 2019