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1. Malonate given at reperfusion prevents post-myocardial infarction heart failure by decreasing ischemia/reperfusion injury

   The mitochondrial metabolite succinate is a key driver of ischemia/reperfusion injury (IRI). Targeting succinate metabolism by inhibiting succinate...

   Jiro Abe, Ana Vujic, ... Thomas Krieg in Basic Research in Cardiology

   Article Open access 12 June 2024
   

2. The roles of intracellular proteolysis in cardiac ischemia–reperfusion injury

   Ischemic heart disease remains a leading cause of human mortality worldwide. One form of ischemic heart disease is ischemia–reperfusion injury caused...

   Bridgette Hartley, Wesam Bassiouni, ... Olivier Julien in Basic Research in Cardiology

   Article 28 September 2023
   

3. Cardioprotective Strategies After Ischemia–Reperfusion Injury

   Acute myocardial infarction (AMI) is associated with high morbidity and mortality worldwide. Although early reperfusion is the most effective...

   Honghong Zhang, Huilin Hu, ... Hongen Tian in American Journal of Cardiovascular Drugs

   Article Open access 10 October 2023
   

4. Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets

   Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following ischemia, exacerbating the initial tissue damage. The limited...

   Meng Zhang, Qian Liu, ... **xiang Yuan in Signal Transduction and Targeted Therapy

   Article Open access 08 January 2024
   

5. The effect of post-reperfusion levosimendan in an experimental intestinal ischemia–reperfusion model

   Background

   Levosimendan has been reported to have a positive effect on ischemia–reperfusion injury. Herein, we aimed to evaluate the effects of...

   Hakan Aygun, Cimen Olguner, ... Serkan Tulgar in Journal of Anesthesia, Analgesia and Critical Care

   Article Open access 27 October 2022
   

6. Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine

   Liver ischemia-reperfusion injury (LIRI) is a pathological process involving multiple injury factors and cell types, with different stages....

   Lei Gao, Yun-jia Li, ... Jian-gang Shen in Chinese Journal of Integrative Medicine

   Article 28 June 2024

7. Ginsenoside Rg3 attenuates myocardial ischemia/reperfusion-induced ferroptosis via the keap1/Nrf2/GPX4 signaling pathway

   Background

   Ginsenoside Rg3 is a component of ginseng that protects against myocardial ischemia/reperfusion (MI/R) injury. Ferroptosis is a new form of...

   GuoFu Zhong, Junteng Chen, ... Ling Wang in BMC Complementary Medicine and Therapies

   Article Open access 26 June 2024
   

8. Identification of a mechanism promoting mitochondrial sterol accumulation during myocardial ischemia–reperfusion: role of TSPO and STAR

   Hypercholesterolemia is a major risk factor for coronary artery diseases and cardiac ischemic events. Cholesterol per se could also have negative...

   Juliette Bréhat, Shirin Leick, ... Didier Morin in Basic Research in Cardiology

   Article 22 March 2024
   

9. Evaluation of renal ischemia–reperfusion injury using CEUS in mice

   Background

   Renal ischemia–reperfusion injury (IRI) frequently occurs clinically. We investigated the value of contrast-enhanced ultrasonography (CEUS)...

   Zixin Xu, **nbao Zhao, ... Wen Dong in European Radiology Experimental

   Article Open access 19 December 2023
   

10. Mitochondria-Associated Organelle Crosstalk in Myocardial Ischemia/Reperfusion Injury

    Organelle damage is a significant contributor to myocardial ischemia/reperfusion (I/R) injury. This damage often leads to disruption of endoplasmic...

    Hui Yao, Yuxin **e, ... Guanghui Yi in Journal of Cardiovascular Translational Research

    Article 28 May 2024
    

11. Penehyclidine hydrochloride alleviates lung ischemia-reperfusion injury by inhibiting pyroptosis

    Objective

    The aim of this research was to examine how penehyclidine hydrochloride (PHC) impacts the occurrence of pyroptosis in lung tissue cells...

    Rongfang Liu, Xuguang Zhang, ... **gui Gao in BMC Pulmonary Medicine

    Article Open access 26 April 2024
    

12. Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection

    Mitochondrial calcium (Ca ²⁺ ) signals play a central role in cardiac homeostasis and disease. In the healthy heart, mitochondrial Ca ²⁺ levels modulate...

    Edoardo Bertero, Tudor-Alexandru Popoiu, Christoph Maack in Basic Research in Cardiology

    Article Open access 19 June 2024
    

13. Bioinformatics integration reveals key genes associated with mitophagy in myocardial ischemia-reperfusion injury

    Background

    Myocardial ischemia is a prevalent cardiovascular disorder associated with significant morbidity and mortality. While prompt restoration of...

    Zhian Chen, Tianying Liu, ... Zhi Liu in BMC Cardiovascular Disorders

    Article Open access 27 March 2024
    

14. Therapeutic Role of Chinese Medicine Targeting Nrf2/HO-1 Signaling Pathway in Myocardial Ischemia/Reperfusion Injury

    Acute myocardial infarction (AMI), characterized by high incidence and mortality rates, poses a significant public health threat. Reperfusion...

    Chang-xing Liu, **n-yi Guo, ... He Wang in Chinese Journal of Integrative Medicine

    Article 08 February 2024

15. A bibliometric study related to the treatment of myocardial ischemia-reperfusion Injury

    Background

    Myocardial ischemia-reperfusion injury (MIRI) is defined as the restoration of blood flow to the myocardium after a brief interruption of...

    Jie Feng, Leilei Han, ... Yanqing Wu in Journal of Cardiothoracic Surgery

    Article Open access 01 July 2024
    

16. The endothelium: gatekeeper to lung ischemia-reperfusion injury

    The success of lung transplantation is limited by the high rate of primary graft dysfunction due to ischemia-reperfusion injury (IRI). Lung IRI is...

    Huy Q. Ta, Maniselvan Kuppusamy, ... Victor E. Laubach in Respiratory Research

    Article Open access 18 April 2024
    

17. The Role of P53 in Myocardial Ischemia-Reperfusion Injury

    Purpose

    P53 is one of the key tumor suppressors. In normal cells, p53 is maintained at low levels by the ubiquitination of the ubiquitinated ligase...

    **-zi Zhu, Zhen Qiu, ... Zhong-yuan **a in Cardiovascular Drugs and Therapy

    Article 30 June 2023
    

18. Long-term inorganic nitrate administration protects against myocardial ischemia-reperfusion injury in female rats

    Background

    The favorable effects of nitrate against myocardial ischemia-reperfusion injury (MIRI) have primarily focused on male rats and in short...

    Younes Yassaghi, Sajad Jeddi, ... Asghar Ghasemi in BMC Cardiovascular Disorders

    Article Open access 21 August 2023
    

19. Targeting Aquaporin-5 by Phosphodiesterase 4 Inhibition Offers New Therapeutic Opportunities for Ovarian Ischemia Reperfusion Injury in Rats

    This study aimed to examine the effect of Phosphodiesterase 4 (PDE4) inhibition on Aquaporin-5 (AQP5) and its potential cell signaling pathway in the...

    Ayse Bozkurt, Zeynep Karakoy, ... Elif Cadirci in Reproductive Sciences

    Article Open access 07 March 2024
    

20. Targeting Gα_i2 in neutrophils protects from myocardial ischemia reperfusion injury

    Neutrophils are not only involved in immune defense against infection but also contribute to the exacerbation of tissue damage after ischemia and...

    David Köhler, Veronika Leiss, ... Sandra Beer-Hammer in Basic Research in Cardiology

    Article Open access 30 May 2024