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Vitamin D supplementation in systemic lupus erythematosus: relationship to disease activity, fatigue and the interferon signature gene expression
BackgroundIn addition to the well-known role of vitamin D in calcium homeostasis and bone metabolism, vitamin D is important in the modulation of the...
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Regulation of type I interferon signature by VGLL3 in the fibroblast-like synoviocytes of rheumatoid arthritis patients via targeting the Hippo pathway
BackgroundThe upregulation of interferon (IFN)-stimulated genes induced by type I IFNs (namely type I IFN signature) in rheumatoid arthritis (RA)...
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Type I interferon pathway in pediatric systemic lupus erythematosus
BackgroundThe role of type I interferon (IFN-I) signaling in systemic lupus erythematosus (SLE) has been well established. However, unanswered...
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Comprehensive analysis of T cell exhaustion related signature for predicting prognosis and immunotherapy response in HNSCC
BackgroundT cell exhaustion (TEX) signifies a condition of T cell disorder which implicate the therapeutic benefits and prognostic significance in...
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Cuproptosis-related DNA methylation signature predict prognosis and immune microenvironment in cutaneous melanoma
The prognosis for Cutaneous Melanoma (CM), a skin malignant tumor that is extremely aggressive, is not good. A recently identified type of controlled...
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A novel subpopulation of monocytes with a strong interferon signature indicated by SIGLEC-1 is present in patients with in recent-onset type 1 diabetes
Aims/hypothesisType 1 diabetes is a T cell-mediated autoimmune disease characterised by pancreatic beta cell destruction. In this study, we explored...
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A novel pyroptosis-related gene signature exhibits distinct immune cells infiltration landscape in Wilms’ tumor
BackgroundWilms’ tumor (WT) is the most common renal tumor in childhood. Pyroptosis, a type of inflammation-characterized and immune-related...
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An immune-related signature for optimizing prognosis prediction and treatment decision of hepatocellular carcinoma
BackgroundAn immune-related gene signature (IGS) was established for discriminating prognosis, predicting benefit of immunotherapy, and exploring...
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Prognostic Signature Constructed of Seven Ferroptosis-Related lncRNAs Predicts the Prognosis of HBV-Related HCC
BackgroundFerroptosis and lncRNAs both play crucial roles in cancers. But the roles of ferroptosis-related lncRNAs (FRLncs) in HBV-related HCC...
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Identification of a prognostic six-immune-gene signature and a nomogram model for uveal melanoma
BackgroundTo identify an immune-related prognostic signature and find potential therapeutic targets for uveal melanoma.
MethodsThe RNA-sequencing...
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Transcriptional control of metabolism by interferon regulatory factors
Interferon regulatory factors (IRFs) comprise a family of nine transcription factors in mammals. IRFs exert broad effects on almost all aspects of...
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Identification and validation of an immune-relevant risk signature predicting survival outcome and immune infiltration in uveal melanoma
PurposeThe current study aimed to reveal a novel immune-related signature to evaluate immune infiltration status and the survival outcome for...
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Characterization of stem cell subtypes and prognostic signature in hepatocellular carcinoma
BackgroundCancer stem cells (CSCs) were linked to cancer aggressiveness and poor prognosis in patients with hepatocellular carcinoma (HCC).
...
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Radiomics signature for dynamic changes of tumor-infiltrating CD8+ T cells and macrophages in cervical cancer during chemoradiotherapy
BackgroundOur previous study suggests that tumor CD8+ T cells and macrophages (defined as CD68+ cells) infiltration underwent dynamic and...
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Role of interferon-induced transmembrane protein family in cancer progression: a special focus on pancreatic cancer
Human interferon-induced transmembrane protein family (IFITMs) consists of five main proteins. IFITM1, IFITM2, and IFITM3 can be induced by...
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Construction of an anoikis‒related prognostic signature to predict immunotherapeutic response and prognosis in hepatocellular carcinoma
PurposeAnoikis resistance is an important inducer of tumor metastasis. The role of anoikis-related genes (ARGs) in hepatocellular carcinoma (HCC)...
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Establishment of a circRNA-regulated E3 ubiquitin ligase signature and nomogram to predict immunotherapeutic efficacy and prognosis in hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) is a common type of malignant tumor where the prognosis is dismal. Circular RNA (CircRNA) is a novel RNA...
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An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
BackgroundAsthma is stratified into type 2-high and type 2-low inflammatory phenotypes. Limited success has been achieved in develo** drugs that...
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A Novel pyroptosis-related signature for predicting prognosis and evaluating tumor immune microenvironment in ovarian cancer
Ovarian cancer (OV) is the most fatal gynecological malignant tumor worldwide, with high recurrence rates and great heterogeneity. Pyroptosis is a...
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A novel PD-1/PD-L1 pathway molecular ty**-related signature for predicting prognosis and the tumor microenvironment in breast cancer
BackgroundCurrently, the development of breast cancer immunotherapy based on the PD-1/PD-L1 pathway is relatively slow, and the specific mechanism...
