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Nuclear Translocation Triggered at the Onset of Hearing in Cochlear Inner Hair Cells of Rats and Mice
PurposeNuclear position is precisely orchestrated during cell division, migration, and maturation of cells and tissues. Here we report a previously...
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A Low Dose of Rapamycin Promotes Hair Cell Differentiation by Enriching SOX2+ Progenitors in the Neonatal Mouse Inner Ear Organoids
PurposeTo investigate the impact of rapamycin on the differentiation of hair cells.
MethodsMurine cochlear organoids were derived from cochlear...
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No Reduction in the 226-Hz Probe Tone Acoustic Reflex Amplitude Following Severe Inner Hair Cell Loss in Chinchillas
The relationship between the middle ear acoustic reflex (AR) and inner hair cell (IHC) loss is currently unknown. Given that IHC are believed to...
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Effect of Selective Carboplatin-Induced Inner Hair Cell Loss on Temporal Integration in Chinchillas
Integration of acoustic information over time is essential for processing complex stimuli, such as speech, due to its continuous variability along...
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Evaluation of cochlear and auditory brainstem functions in COVID-19 patients; a case control study
BackgroundMany viral infections can cause hearing loss due to affection of cochlear hair cells or neurogenic pathway. Although, the damage secondary...
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Organoids—the key to novel therapies for the inner ear?
The sensitivity and the complexity of the human inner ear in conjunction with the lack of regenerative capacity are the main reasons for hearing loss...
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Histological Correlates of Auditory Nerve Injury from Kainic Acid in the Budgerigar (Melopsittacus undulatus)
PurposeLoss of auditory nerve afferent synapses with cochlear hair cells, called cochlear synaptopathy, is a common pathology in humans caused by...
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A systematic review of the efficacy of cochlear implantation in adults with auditory neuropathy spectrum disorders
BackgroundAuditory neuropathy spectrum disorder (ANSD) is characterized by normal outer hair cell functioning alongside compromised auditory nerve...
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AAV-ie-K558R mediated cochlear gene therapy and hair cell regeneration
The cochlea consists of multiple types of cells, including hair cells, supporting cells and spiral ganglion neurons, and is responsible for...
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Evaluation of Auditory Functions in Patients with Psoriasis
Our study aims to evaluate the functions of the middle and inner ear and the efferent auditory system in psoriasis. Hearing thresholds, resonance...
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Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair cells
Oxidative stress plays an important role in the pathogenesis of aminoglycoside-induced hearing loss and represents a promising target for treatment....
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Auditory Neuropathy Spectrum Disorder in Individuals with Sickle Cell Anemia: Case Study
The present study attempted to understand the association between Auditory neuropathy spectrum disorder (ANSD) and Sickle cell anemia (SCA) and to...
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The effects of stress on auditory system: a narrative review
BackgroundStress is an integral part of human life, small amounts of which can be effective in adapting to conditions, while its continuous increase...
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The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea
The cochlea of the mammalian inner ear includes an active, hydromechanical amplifier thought to arise via the piezoelectric action of the outer hair...
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The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell
In 1985, Bill Brownell and colleagues published the remarkable observation that cochlear outer hair cells (OHCs) express voltage-driven mechanical...
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Superior Semicircular Canal Dehiscence: a Potential Cause of Vestibular and Auditory Impairment Following Head Trauma
Purpose of ReviewSymptomatic superior semicircular canal dehiscence (SSCD) consists of a wide array of auditory and vestibular symptoms that result...
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Prevalence and Auditory Characteristics of Auditory Neuropathy Spectrum Disorder in Adult Population with Sensory Neural Hearing Loss: A Hospital Based Study in South India
Auditory neuropathy spectrum disorder (ANSD) is a heterogenous group of disorder characterized by abnormalities in auditory brainstem responses (ABR)...
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Differentiation capacity of dental pulp stem cell into inner ear hair cell using an in vitro assay: a preliminary step toward treating sensorineural hearing loss
PurposeSensorineural hearing loss (SNHL) is commonly caused by the death or dysfunction of cochlear cell types as a result of their lack of...
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Investigating white matter changes in auditory cortex and association fibres related to speech processing in noise-induced hearing loss: a diffusion tensor imaging study
BackgroundThis study explores the impact of noise-induced hearing loss (NIHL) on the microstructural integrity of white matter tracts in the brain,...
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Gap Detection Deficits in Chinchillas with Selective Carboplatin-Induced Inner Hair Cell Loss
Temporal resolution is essential for processing complex auditory information such as speech. In hearing impaired persons, temporal resolution, often...
