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Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow
PurposeAlthough pediatric low-grade gliomas (pLGG) are the most common pediatric brain tumors, patient-derived cell lines reflecting pLGG biology in...
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A fail-safe system to prevent oncogenesis by senescence is targeted by SV40 small T antigen
Whereas large T antigen (LT) of simian virus 40 (SV40) promotes oncogenesis by inactivating the tumor suppressor proteins p53 and pRb, SV40 small T...
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Guanylate-binding protein 1 inhibits nuclear delivery of pseudorabies virus by disrupting structure of actin filaments
The alphaherpesvirus pseudorabies virus (PRV) is the causative agent of pseudorabies, responsible for severe economic losses to the swine industry...
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Dual roles of myocardial mitochondrial AKT on diabetic cardiomyopathy and whole body metabolism
BackgroundThe PI3K/AKT pathway transduces the majority of the metabolic actions of insulin. In addition to cytosolic targets, insulin-stimulated...
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Recent progress of experimental model in pancreatic neuroendocrine tumors: drawbacks and challenges
The neuroendocrine neoplasm, in general, refers to a heterogeneous group of all tumors originating from peptidergic neurons and neuroendocrine cells....
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Diverse actions of sirtuin-1 on ovulatory genes and cell death pathways in human granulosa cells
BackgroundHuman granulosa-lutein cells (hGLCs) amply express sirtuin-1 (SIRT1), a NAD + -dependent deacetylase that is associated with various...
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Characterization of translocon proteins in the type III secretion system of Lawsonia intracellularis
Lawsonia intracellularis , the etiologic agent of proliferative enteropathy (PE), is an obligate intracellular Gram-negative bacterium possessing a...
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Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors
Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous population of neoplasms that arise from hormone-secreting islet cells of the pancreas...
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Genetically engineered mouse models of head and neck cancers
The head and neck region is one of the anatomic sites commonly afflicted by cancer, with ~1.5 million new diagnoses reported worldwide in 2020 alone....
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Overcoming resistance to immunotherapy by targeting GPR84 in myeloid-derived suppressor cells
Myeloid-derived suppressor cells (MDSCs) were found to gradually accumulate in the orthotopic esophageal cancer mouse model during tumor progression....
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Hypoxia signaling in human health and diseases: implications and prospects for therapeutics
Molecular oxygen (O 2 ) is essential for most biological reactions in mammalian cells. When the intracellular oxygen content decreases, it is called...
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Aberrant granulosa cell-fate related to inactivated p53/Rb signaling contributes to granulosa cell tumors and to FOXL2 downregulation in the mouse ovary
Ovarian granulosa cell tumors (GCTs) are indolent tumors of the ovary affecting women at all ages and potentially displaying late recurrence. Even if...
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The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses
Prostate cancer (PCa), the second leading cause of death in American men, includes distinct genetic subtypes with distinct therapeutic...
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Adeno-associated virus as a delivery vector for gene therapy of human diseases
Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to...
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Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy
Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are considered as specialized immune cells that can be...
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A CRISPR knockout screen reveals new regulators of canonical Wnt signaling
The Wnt signaling pathways play fundamental roles during both development and adult homeostasis. Aberrant activation of the canonical Wnt signal...
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Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity
The crucial role of interferon (IFN) signaling is well known in the restriction or eradication of pathogen invasion. Viruses take a variety of ways...
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Roles of airway basal stem cells in lung homeostasis and regenerative medicine
Airway basal stem cells (BSCs) in the proximal airways are recognized as resident stem cells capable of self-renewing and differentiating to...
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Establishment of an Immortalized Endometriotic Stromal Cell Line from Human Ovarian Endometrioma
Endometrial-like stromal cells, one of the main components of endometriotic lesions, are an important in vitro model for studying cellular and...
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Mobilization of monocytic myeloid-derived suppressor cells is regulated by PTH1R activation in bone marrow stromal cells
Myeloid-derived suppressor cells (MDSCs) are bone marrow (BM)-derived immunosuppressive cells in the tumor microenvironment, but the mechanism of...
