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Immortalization effect of SV40T lentiviral vectors on canine corneal epithelial cells
BackgroundPrimary canine corneal epithelial cells (CCECs) easily become senescent, and cell proliferation is limited. Therefore, sampling for...
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Establishing a papillary craniopharyngioma cell line by SV40LT-mediated immortalization
BackgroundCraniopharyngioma represents a troublesome tumor of the intracranial sellar region. There are currently no available well-characterized...
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Establishment of Immortalized Human Endometriotic Stromal Cell Line from Ectopic Lesion of a Patient with Endometriosis
Endometriosis is an estrogen-dependent inflammatory disease characterized by the growth of endometrial-like tissues containing endometrial stromal...
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The Epstein–Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization
Epstein–Barr virus (EBV) immortalizes human B-lymphocytes and is implicated in the pathogenesis of lymphoid and epithelial cell malignancies. The EBV...
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Correction: Disruption of the retinoblastoma pathway by small interfering RNA and ectopic expression of the catalytic subunit of telomerase lead to immortalization of human ovarian surface epithelial cells
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Gastric cancer exosomes contribute to the field cancerization of gastric epithelial cells surrounding gastric cancer
BackgroundA dynamic molecular interaction between cancer and the surrounding normal cells is mediated through exosomes. We investigated whether...
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20 Years with SGBS cells - a versatile in vitro model of human adipocyte biology
20 years ago, we described a human cell strain derived from subcutaneous adipose tissue of an infant supposed to have Simpson-Golabi-Behmel Syndrome...
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Establishment of an Immortalized Endometriotic Stromal Cell Line from Human Ovarian Endometrioma
Endometrial-like stromal cells, one of the main components of endometriotic lesions, are an important in vitro model for studying cellular and...
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Generation and application of immortalized sheep fetal fibroblast cell line
BackgroundPrimary sheep fetal fibroblasts (SFFCs) have emerged as a valuable resource for investigating the molecular and pathogenic mechanisms of...
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Correction: The Epstein–Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization
This article was originally published under Springer Nature’s License to Publish, but has now been made available under a CC BY 4.0 license. The PDF...
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Improvement of erectile dysfunction using endothelial progenitor cells from fetal cerebral vasculature in the cavernous nerve injury of rats
BackgroundBecause of limited differentiation to endothelium from mesenchymal stem cells, it has been strongly recommended to use endothelial...
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Patient-Specific Sarcoma Organoids for Personalized Translational Research: Unification of the Operating Room with Rare Cancer Research and Clinical Implications
IntroductionSarcoma clinical outcomes have been stagnant for decades due to heterogeneity of primaries, lack of comprehensive preclinical models, and...
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Prognostic value of TERF1 expression in prostate cancer
BackgroundTelomere dysfunction is one of the hallmarks of cancer and is crucial to prostate carcinogenesis. TERF1 is a gene essential to telomere...
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The peculiar features, diversity and impact of citrulline-reactive autoantibodies
Since entering the stage 25 years ago as a highly specific serological biomarker for rheumatoid arthritis, anti-citrullinated protein antibodies...
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Hitting Epstein Barr virus where it hurts: computational methods exploration for siRNA therapy in alleviating Epstein Barr virus-induced multiple sclerosis
Multiple sclerosis (MS), an intricate neurological disorder, continues to challenge our understanding of the pivotal interplay between the immune...
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Induction of enucleation in primary and immortalized erythroid cells
Enucleation is a crucial event during the erythropoiesis, implicating drastic morphologic and transcriptomic/proteomic changes. While many genes...
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Helicobacter pylori cagA status and gastric mucosa-associated lymphoid tissue lymphoma: a systematic review and meta-analysis
BackgroundRecent studies have investigated the role of Helicobacter pylori infection in the development of gastric mucosa-associated lymphoid tissue...
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A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinoma
BackgroundMicro-RNAs (miRNAs) have been reported as an emerging biomarker in many cancer types. They are used as diagnostic and prognostic biomarkers...
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The role of FoxM1 in immune cells
Forkhead box M1 (FoxM1), a proliferation specific transcriptional modulator, plays a principal role in many physiological and pathological processes....
