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Structural- and DTI- MRI enable automated prediction of IDH Mutation Status in CNS WHO Grade 2–4 glioma patients: a deep Radiomics Approach
BackgroundThe role of isocitrate dehydrogenase (IDH) mutation status for glioma stratification and prognosis is established. While structural...
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The diagnostic efficiency of integration of 2HG MRS and IVIM versus individual parameters for predicting IDH mutation status in gliomas in clinical scenarios: A retrospective study
PurposeCurrently, there remains a scarcity of established preoperative tests to accurately predict the isocitrate dehydrogenase (IDH) mutation status...
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Development of End-to-End AI–Based MRI Image Analysis System for Predicting IDH Mutation Status of Patients with Gliomas: Multicentric Validation
Radiogenomics has shown potential to predict genomic phenotypes from medical images. The development of models using standard-of-care pre-operative...
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Easy-to-use machine learning system for the prediction of IDH mutation and 1p/19q codeletion using MRI images of adult-type diffuse gliomas
Adult-type diffuse gliomas are divided into Astrocytoma, IDH-mutant, Oligodendroglioma, IDH-mutant and 1p/19q-codeleted and Glioblastoma,...
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Quantifying H&E staining results, grading and predicting IDH mutation status of gliomas using hybrid multi-dimensional MRI
ObjectiveTo assess the performance of hybrid multi-dimensional magnetic resonance imaging (HM-MRI) in quantifying hematoxylin and eosin (H&E)...
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Prediction of Ki-67 labeling index, ATRX mutation, and MGMT promoter methylation status in IDH-mutant astrocytoma by morphological MRI, SWI, DWI, and DSC-PWI
ObjectiveNoninvasive detection of molecular status of astrocytoma is of great clinical significance for predicting therapeutic response and...
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Enhancing predictability of IDH mutation status in glioma patients at initial diagnosis: a comparative analysis of radiomics from MRI, [18F]FET PET, and TSPO PET
PurposeAccording to the World Health Organization classification for tumors of the central nervous system, mutation status of the isocitrate...
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The role of DSC MR perfusion in predicting IDH mutation and 1p19q codeletion status in gliomas: meta-analysis and technical considerations
PurposeIsocitrate dehydrogenase (IDH) mutation and 1p19q codeletion status are important for managing glioma patients. However, current practice...
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A nomogram strategy for identifying the subclassification of IDH mutation and ATRX expression loss in lower-grade gliomas
ObjectivesTo construct a radiomics nomogram based on multiparametric MRI data for predicting isocitrate dehydrogenase 1 mutation (IDH +) and loss of...
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Predicting TERT promoter mutation status using 1H-MR spectroscopy and stretched-exponential model of diffusion-weighted imaging in IDH-wildtype diffuse astrocytic glioma without intense enhancement
PurposeIsocitrate dehydrogenase (IDH )-wildtype diffuse astrocytic glioma with telomerase reverse transcriptase ( TERT ) promoter mutation is defined...
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3D Amide Proton Transfer-Weighted Imaging for Grading Glioma and Correlating IDH Mutation Status: Added Value to 3D Pseudocontinuous Arterial Spin Labelling Perfusion
PurposeThe goal of this study was to evaluate the diagnostic performance of 3D amide proton transfer-weighted (3D-APTW) imaging and 3D...
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Development and validation of clinical-radiomics analysis for preoperative prediction of IDH mutation status and WHO grade in diffuse gliomas: a consecutive l-[methyl-11C] methionine cohort study with two PET scanners
PurposeDetermination of isocitrate dehydrogenase ( IDH ) genotype is crucial in the stratification of diagnosis and prognostication in diffuse...
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Mean apparent propagator-MRI in evaluation of glioma grade, cellular proliferation, and IDH-1 gene mutation status
ObjectivesTo evaluate the glioma grade, Ki-67 expression, and IDH-1 mutation status using mean apparent propagator (MAP) MRI.
Methods ...
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Radiogenomic association between the T2-FLAIR mismatch sign and IDH mutation status in adult patients with lower-grade gliomas: an updated systematic review and meta-analysis
ObjectivesTo reveal a radiogenomic correlation between the presence of the T2-fluid-attenuated inversion recovery resection (T2-FLAIR) mismatch sign...
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A three-component multi-b-value diffusion-weighted imaging might be a useful biomarker for detecting microstructural features in gliomas with differences in malignancy and IDH-1 mutation status
ObjectivesThe purpose of the study was to explore the performance of a three-component diffusion model in evaluating the degree of malignancy and...
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Multicenter clinical radiomics–integrated model based on [18F]FDG PET and multi-modal MRI predict ATRX mutation status in IDH-mutant lower-grade gliomas
ObjectivesTo develop a clinical radiomics–integrated model based on 18 F-fluorodeoxyglucose positron emission tomography ([ 18 F]FDG PET) and...
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Genomic landscape of glioblastoma without IDH somatic mutation in 42 cases: a comprehensive analysis using RNA sequencing data
PurposeGlioblastoma is a malignant brain tumor with a poor prognosis. Genetic mutations associated with this disease are complex are not fully...
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Multi-tracer and multiparametric PET imaging to detect the IDH mutation in glioma: a preclinical translational in vitro, in vivo, and ex vivo study
BackgroundThis translational study explores multi-tracer PET imaging for the non-invasive detection of the IDH1 mutation which is a positive...
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Predicting IDH mutation status of lower grade gliomas using standard MR imaging features and apparent diffusion coefficient
PurposeThe purpose of this study was to investigate the predictive value of standard MR imaging features and apparent diffusion coefficient (ADC)...
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Prediction of TERTp-mutation status in IDH-wildtype high-grade gliomas using pre-treatment dynamic [18F]FET PET radiomics
PurposeTo evaluate radiomic features extracted from standard static images (20–40 min p.i.), early summation images (5–15 min p.i.), and dynamic [ 18 F...
