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HLA-DRB1 haplotypes predict cardiovascular mortality in inflammatory polyarthritis independent of CRP and anti-CCP status
BackgroundHaplotypes defined by amino acids at HLA-DRB1 positions 11, 71 and 74 associated with susceptibility to rheumatoid arthritis (RA) are...
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HLA haploidentical stem cell transplantation from HLA homozygous donors to HLA heterozygous donors may have lower survival rates than haploidentical transplantation from HLA heterozygous donors to HLA heterozygous donors: a retrospective nationwide analysis
In HLA haploidentical stem cell transplantation, patients and donors usually share one HLA haplotype and have one different HLA haplotype...
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Human leukocyte antigen (HLA) haplotype matching in unrelated single HLA allele mismatch bone marrow transplantation
The role of matching human leukocyte antigen (HLA) haplotypes in unrelated allogeneic bone marrow transplantation (allo-BMT) remains unclear. Here,...
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The HLA profile and genetic affinities of three primitive Tamil-speaking endogamous groups: Kallars of Thanjavur, Piramalai Kallar and Vanniyar
BackgroundThe present study was aimed to study the frequencies of HLA-DRB1/-DQB1 alleles and haplotypes of three endogamous groups of Tamil Nadu...
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Investigating the Correlation Between HLA-II Gene Polymorphism and RhE Alloimmunization in Pregnant Chinese Women
The Rhesus (Rh) blood group is a significant and complicated biological system in humans. Incompatible transfusion or pregnancy with Rh antigens can...
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Frequency of HLA alleles and KIR Ligands in Acute Myeloid Leukemia in Indian Cohort
Relationship between various combinations of KIR ligands and HLA alleles have been studied in several diseases. The aim of this retrospective study...
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Prognostic impact of HLA supertype mismatch in single-unit cord blood transplantation
The “human leukocyte antigen (HLA) supertype” is a functional classification of HLA alleles, which was defined by structural features and peptide...
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Distribution of celiac disease predisposing genes HLA-DQ2 and HLA-DQ8 in the native population of southern India
BackgroundCeliac disease (CD) is an intestinal inflammatory condition caused by the ingestion of gluten peptides in wheat and related grains in...
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Frequent HLA-DR loss on hematopoietic stem progenitor cells in patients with cyclosporine-dependent aplastic anemia carrying HLA-DR15
To determine whether antigen presentation by HLA-DR on hematopoietic stem progenitor cells (HSPCs) is involved in the development of acquired...
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The impact of HLA-DRB1 alleles in a Hellenic, Pediatric-Onset Multiple Sclerosis cohort: Implications on clinical and neuroimaging profile
BackgroundPediatric-Onset Multiple Sclerosis (POMS) is considered a complex disease entity and several genetic, hormonal, and environmental factors...
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HLA-B27 did not protect against COVID-19 in patients with axial spondyloarthritis – data from the ReumaCov-Brasil Registry
BackgroundSome studies have suggested the HLA-B27 gene may protect against some infections, as well as it could play a benefit role on the viral...
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The role of HLA genotypes in understanding the pathogenesis of severe COVID-19
The coronavirus disease 2019 (COVID-19) pandemic has caused human tragedy through the global spread of the viral pathogen SARS-CoV-2. Although the...
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HLA alleles associated with COVID-19 susceptibility and severity in different populations: a systematic review
BackgroundCOVID-19 is a respiratory disease caused by a novel coronavirus called as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)....
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HLA-DQB1*05:02, *05:03, and *03:01 alleles as risk factors for myasthenia gravis in a Spanish cohort
BackgroundMyasthenia gravis (MG) is a very heterogenic chronic autoimmune disease caused by the failure of neuromuscular transmission. The HLA gene...
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Potential Implication of HLA-DQ Heterodimer High-Resolution Ty** on Kidney Transplant Outcomes and Equity
Purpose of ReviewTo evaluate the potential implications of HLA-DQαβ heterodimer high-resolution ty** on clinical decision-making in solid organ...
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HLA-DR3 ~ DQ2 associates with sensory neuropathy in paraneoplastic neurological syndromes with Hu antibodies
ObjectivesTo investigate the association between human leukocyte antigen (HLA) and paraneoplastic neurological syndromes (PNS) with Hu antibodies,...
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The influence of HLA genotype on the development of metal hypersensitivity following joint replacement
BackgroundOver five million joint replacements are performed across the world each year. Cobalt chrome (CoCr) components are used in most of these...
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The HLA-Cw*06 allele may predict the response to methotrexate (MTX) treatment in Chinese arthritis-free psoriasis patients
MTX in genetically distinctive Chinese psoriatic patients remains less explored. The present study aimed to determine the impact of HLA-Cw*06 on MTX...
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Inflammatory human leucocyte antigen genotypes are not a risk factor in chronic subdural hematoma development
BackgroundChronic subdural hematoma (CSDH) pathophysiology has undergone a paradigm shift from being regarded as solely traumatic to be driven mainly...
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Smoking, use of smokeless tobacco, HLA genotypes and incidence of latent autoimmune diabetes in adults
Aims/hypothesesSmoking and use of smokeless tobacco (snus) are associated with an increased risk of type 2 diabetes. We investigated whether smoking...
