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Neuroblastoma susceptibility and association of N7-methylguanosine modification gene polymorphisms: multi-center case-control study
BackgroundNeuroblastoma (NB) is a common extracranial solid malignancy in children. The N7-methylguanosine (m 7 G) modification gene METTL1 / WDR4 ...
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A study on genotypes and phenotypes of short stature caused by epigenetic modification gene variants
Mendelian disorders of the epigenetic machinery (MDEMs) are caused by genetic mutations, a considerable fraction of which are associated with...
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Post-transcriptional regulation of tumor suppressor gene lncRNA CARMN via m6A modification and miRNA regulation in cervical cancer
PurposeThe abnormal regulation of lncRNA CARMN has been proved to be a tumor suppressor gene of cervical cancer (CC). However, its role in CC is...
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RNA modification in cardiovascular disease: implications for therapeutic interventions
Cardiovascular disease (CVD) is the leading cause of death in the world, with a high incidence and a youth-oriented tendency. RNA modification is...
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Expression patterns and prognostic value of key regulators associated with m7G RNA modification based on all gene expression in colon adenocarcinoma
BackgroundN7-methylguanosine (m7G) is present in a wide variety of organisms and has important roles. m7G has been reported to be involved in...
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N6‐methyladenosine (m6A) Modification in Preeclampsia
Recently, epitranscriptional modification of N6-methyladenosine (m6A) has received growing attention in the research on the pathogenesis of...
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RNA modification-mediated mRNA translation regulation in liver cancer: mechanisms and clinical perspectives
Malignant liver cancer is characterized by rapid tumour progression and a high mortality rate, whereas the molecular mechanisms underlying liver...
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m6A modification patterns are associated with copy number burden and tumor immune landscape in thyroid cancer
BackgroundThe association involving N6-methyladenosine (m6A) modification, molecular subtype and specific immune cell group in tumor microenvironment...
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M6A methylation modification in autoimmune diseases, a promising treatment strategy based on epigenetics
BackgroundN6-methyladenosine (m6A) methylation modification is involved in the regulation of various biological processes, including inflammation,...
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O-GlcNAcylation Modification in Immune Cells: Potential Therapeutic Implications of Sepsis
O-GlcNAc modification is a glycosylation modification that is commonly observed in nuclear and organelle proteins of cells. In recent years, several...
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RNA modification “writer”-mediated RNA modification patterns and tumor microenvironment characteristics of cervical cancer
PurposeAs an epigenetic regulation mechanism after transcription, RNA modification is installed by endogenous "writer" enzymes and is widely involved...
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Peritoneal high-fat environment promotes peritoneal metastasis of gastric cancer cells through activation of NSUN2-mediated ORAI2 m5C modification
Peritoneal metastasis (PM) is an important metastatic modality of gastric cancer (GC).It is associated with poor prognosis. The underlying molecular...
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N6-methyladenosine modification and post-translational modification of epithelial–mesenchymal transition in colorectal cancer
Colorectal cancer is a leading cause of cancer-related mortality worldwide. Traditionally, colorectal cancer has been recognized as a disease caused...
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N7-methylguanosin regulators-mediated methylation modification patterns and characterization of the immune microenvironment in lower-grade glioma
N7-methylguanosine (m7G) modification signature has recently emerged as a crucial regulator of tumor progression and treatment in cancer. However,...
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N6-methyladenosine regulator-mediated methylation modification patterns and immune infiltration characterization in Polycystic Ovary Syndrome (PCOS)
BackgroundPolycystic ovary syndrome (PCOS) is a multisystem-related disease whose pathophysiology is still unclear. Several regulators of...
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Emerging roles of m6A RNA modification in cancer therapeutic resistance
Marvelous advancements have been made in cancer therapies to improve clinical outcomes over the years. However, therapeutic resistance has always...
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The role of RNA modification in urological cancers: mechanisms and clinical potential
RNA modification is a post-transcriptional level of regulation that is widely distributed in all types of RNAs, including mRNA, tRNA, rRNA, miRNA,...
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Effects of CpG sites methylation modification of HPV16 integration essential gene on the proliferation of cervical cancer cells
PurposeThe mechanism of methylation of HPV CpG sites in the occurrence and prognosis of cervical carcinogenesis remains unclear. We investigated the...
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METTL3-mediated N6-methyladenosine modification of STAT5A promotes gastric cancer progression by regulating KLF4
N 6 -methyladenosine (m 6 A) is the predominant post-transcriptional RNA modification in eukaryotes and plays a pivotal regulatory role in various...
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METTL14-mediated N6-methyladenosine modification induces the ferroptosis of hypoxia/reoxygenation-induced cardiomyocytes
BackgroundHypoxia/reoxygenation (H/R) induces cardiomyocyte ferroptosis, a core remodeling event in myocardial ischemia/reperfusion injury....
