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Preventing high-fat diet-induced obesity and related metabolic disorders by hydrodynamic transfer of Il-27 gene
Background and objectivesInterleukin-27 (IL-27) is a multifaceted heterodimer cytokine that exerts both pro-inflammatory and anti-inflammatory...
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Embryo Transfer Strategies for Women with Recurrent Implantation Failure During the Frozen-thawed Embryo Transfer Cycles: Sequential Embryo Transfer or Double-blastocyst Transfer?
ObjectiveBoth sequential embryo transfer (SeET) and double-blastocyst transfer (DBT) can serve as embryo transfer strategies for women with recurrent...
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Stable long-term germline transmission of GFP transgenic rat via PiggyBac transposon mediated gene transfer
Transgene silencing provides a significant challenge in animal model production via gene engineering using viral vectors or transposons. Selecting an...
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Gene polymorphisms of VEGF and KDR are associated with initial fast peritoneal solute transfer rate in peritoneal dialysis
BackgroundPeritoneal dialysis (PD) is an effective and successful renal replacement therapy. The baseline peritoneal solute transfer rate (PSTR) is...
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Gut microbiota transfer evidence from mother to newborn
Early life microbiota is a risk factor for future diseases. The main purpose of this study was to investigate the transfer of gut microbiota from...
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First case of dichorionic diamniotic triplet pregnancy after single blastocyst transfer
Multiple pregnancies are associated with significant maternal, fetal, and neonatal risks, including prematurity, low birth weight, pre-eclampsia,...
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Impact of vaginal microecological differences on pregnancy outcomes and endometrial microbiota in frozen embryo transfer cycles
PurposeThis prospective study investigates the correlation between vaginal microecology and pregnancy outcomes and explores their impact on...
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Gene expression networks regulated by human personality
Genome-wide association studies of human personality have been carried out, but transcription of the whole genome has not been studied in relation to...
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Which transfer day results in the highest live birth rate for PCOS patients undergoing in vitro fertilization?
BackgroundPolycystic ovary syndrome (PCOS) has unusual levels of hormones. The hormone receptors in the endometrium have a hostile effect and make...
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Trade-off between double cleavage-stage embryos transfer and single blastocyst-stage embryo transfer in patients with few good quality embryos in antagonist cycles: a retrospective study using a propensity score matching analysis
ObjectiveThis study aimed to compare the per OPU clinical outcomes for transfer of Day 3 double cleavage-stage embryos (DET) and Day 5 single...
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Sequential embryo transfer combined with intrauterine perfusion improved pregnancy outcomes in patients with recurrent implantation failure
ObjectiveTo compare the application of sequential embryo transfer, cleavage embryo transfer, and blastocyst transfer combined with intrauterine...
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A combined clinical and specific genes’ model to predict live birth for in vitro fertilization and embryo transfer patients
BackgroundWe aimed to develop an accurate model to predict live birth for patients receiving in vitro fertilization and embryo transfer (IVF-ET)...
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NK cell transfer overcomes resistance to PD-(L)1 therapy in aged mice
BackgroundCancer is the leading cause of death among older adults. Although the integration of immunotherapy has revolutionized the therapeutic...
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Live birth rates after resolution of endometrial cavity fluid in frozen embryo transfer cycles
Research questionAre live birth rates affected in frozen embryo transfer cycles that develop transient endometrial cavity fluid that resolves by day...
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Acid ceramidase gene therapy ameliorates pulmonary arterial hypertension with right heart dysfunction
BackgroundUp-regulation of ceramides in pulmonary hypertension (PH), contributing to perturbations in sphingolipid homeostasis and the transition of...
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Gene therapy: principles, challenges and use in clinical practice
IntroductionGene therapy is an emerging topic in medicine. The first products have already been licensed in the European Union for the treatment of...
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Macrophage polarization toward M1 phenotype in T cell transfer colitis model
BackgroundT cell transfer colitis model is often used to study the CD4 + T cell functions in the intestine. However, the specific roles of...
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Structure-based mechanism and inhibition of cholesteryl ester transfer protein
Purpose of ReviewCholesteryl ester transfer proteins (CETP) regulate plasma cholesterol levels by transferring cholesteryl esters (CEs) among...
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The sodium iodide symporter (NIS) as theranostic gene: potential role in pre-clinical therapy of extra-thyroidal malignancies
PurposeSodium iodide symporter (NIS), as a broadly exploited cancer theranostic molecule, has attracted considerable interest in non-thyroidal...
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Multi-pool chemical exchange saturation transfer MRI in glioma grading, molecular subty** and evaluating tumor proliferation
PurposeTo evaluate the performance of multi-pool Chemical exchange saturation transfer (CEST) MRI in prediction of glioma grade, isocitrate...
