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The methylation level of a single cancer risk marker gene reflects methylation burden in gastric mucosa
BackgroundGastric cancer risk can be accurately predicted by measuring the methylation level of a single marker gene in gastric mucosa. However, the...
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The regulatory role of cancer stem cell marker gene CXCR4 in the growth and metastasis of gastric cancer
Single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing (bulk RNA-seq) are increasingly used for screening genes involved in carcinogenesis...
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Clinicopathological characteristics of gastric adenocarcinoma with enteroblastic differentiation and gastric adenocarcinoma with enteroblastic marker expression
Gastric adenocarcinoma (GA) with enteroblastic differentiation (GAED) is an aggressive carcinoma histologically characterized by a glycogen-rich...
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MTF1 has the potential as a diagnostic and prognostic marker for gastric cancer and is associated with good prognosis
PurposeMetal Regulatory Transcription Factor 1 (MTF1) can be an essential transcription factor for heavy metal response in cells and can also reduce...
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CD44v3 is a marker of invasive cancer stem cells driving metastasis in gastric carcinoma
BackgroundCancer stem cells (CSCs) are at the origin of tumour initiation and progression in gastric adenocarcinoma (GC). However, markers of...
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Expression of 5-HT Relates to Stem Cell Marker LGR5 in Patients with Gastritis and Gastric Cancer
Background5-Hydroxytryptamine (5-HT) and stem cells marker G-protein-coupled receptor 5 (LGR5) are associate with gastrointestinal inflammation and...
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CircUSP1 as a novel marker promotes gastric cancer progression via stabilizing HuR to upregulate USP1 and Vimentin
Circular RNAs (circRNAs) play a crucial role in regulating various tumors. However, their biological functions and mechanisms in gastric cancer (GC)...
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LUM as a novel prognostic marker and its correlation with immune infiltration in gastric cancer: a study based on immunohistochemical analysis and bioinformatics
BackgroundGastric cancer (GC) is considered the sixth highly prevailing malignant neoplasm and is ranked third in terms of cancer mortality rates. To...
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Is the Prognostic Nutritional Index a Prognostic Marker for the Survival of Patients with Lymph-Node Positive Stage II-III Gastric Cancer Who Receive Adjuvant Chemotherapy?
PurposeThe prognostic nutritional index (PNI), like other systemic inflammatory markers, has been shown to be a prognostic factor in various cancer...
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Revolutionizing Gastric Cancer Prevention: Novel Insights on Gastric Mucosal Inflammation-Cancer Transformation and Chinese Medicine
The progression from gastric mucosal inflammation to cancer signifies a pivotal event in the trajectory of gastric cancer (GC) development. Chinese...
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Gastric microbiome signature for predicting metachronous recurrence after endoscopic resection of gastric neoplasm
BackgroundChanges in gastric microbiome are associated with gastric carcinogenesis. Studies on the association between gastric mucosa-associated...
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The tissue-resident marker CD103 on peripheral blood T cells predicts responses to anti-PD-1 therapy in gastric cancer
BackgroundImmune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. Since clinical benefits are limited to a subset of patients, we...
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Serum creatinine/cystatin C ratio as a surrogate marker for sarcopenia in patients with gastric cancer
BackgroundSarcopenia is an age-related syndrome that may have negative impact on surgical outcomes and long-term survival of patients with gastric...
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PPARδ dysregulation of CCL20/CCR6 axis promotes gastric adenocarcinoma carcinogenesis by remodeling gastric tumor microenvironment
BackgroundPeroxisome proliferator-activated receptor delta (PPARδ) promotes inflammation and carcinogenesis in many organs, but the underlying...
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Non-invasive Testing in Gastric Diseases
Purpose of ReviewNon-invasive markers for gastric disease are highly useful, ideally allowing to diagnose a disease or a condition in a simple and...
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Comparison of Clinicopathological Features and Prognosis of Mucinous Gastric Carcinoma and other Gastric Cancers: A Retrospective Study of 4,417 Patients
BackgroundMucinous gastric carcinoma (MGC) is a distinct histologic subtype of gastric cancer (GC) that is often diagnosed at an advanced stage. The...
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Gastric neuroendocrine neoplasms
Gastric neuroendocrine neoplasms (gNENs) display peculiar site-specific features among all NENs. Their incidence and prevalence have been rising in...
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Current status of immunotherapy in gastric cancer
Gastric cancer is one of the most common cancer with high mortality and morbilidity in East Asia, especially in China. In recent year, new treatment...
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Clinical practice guidelines for molecular tumor marker, 2nd edition review part 2
In recent years, rapid advancement in gene/protein analysis technology has resulted in target molecule identification that may be useful in cancer...
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Generation of human gastric assembloids from primary fetal organoids
PurposeUnderstanding human gastric epithelium homeostasis remains partial, motivating the exploration of innovative in vitro models. Recent...