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Evaluating H3F3A K27M and G34R/V somatic mutations in a cohort of pediatric brain tumors of different and rare histologies
PurposeSomatic mutations on H3 histone are currently considered a genetic hallmark for midline pediatric high-grade gliomas (HGGs). Yet, different...
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H3 G34-mutant high-grade gliomas: integrated clinical, imaging and pathological characterisation of a single-centre case series
BackgroundDiffuse hemispheric glioma, H3 G34-mutant, is a novel paediatric tumour type in the fifth edition of the WHO classification of CNS tumours...
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Epigenetics to clinicopathological features: a bibliometric analysis of H3 G34-mutant diffuse hemispheric glioma literature
PurposePediatric-type diffuse high-grade gliomas are the leading cause of cancer-related morbidity and mortality in children. More than 30% of...
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Midline invasion predicts poor prognosis in diffuse hemispheric glioma, H3 G34-mutant: an individual participant data review
IntroductionDiffuse hemispheric glioma, H3 G34-mutant (DHGs), is a newly categorized tumor in pediatric-type diffuse high-grade gliomas, World Health...
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Genetic and other epidemiological risk factors of infants and children with hypospadias: a case control study
BackgroundTo study hypospadias as regard epidemiological risk factors and genetic association with mutations in Steroid 5 alpha reductase type 2...
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Imaging features associated with H3 K27-altered and H3 G34-mutant gliomas: a narrative systematic review
BackgroundAdvances in molecular diagnostics accomplished the discovery of two malignant glioma entities harboring alterations in the H3 histone:...
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The epigenetic dysfunction underlying malignant glioma pathogenesis
Comprehensive molecular profiling has dramatically transformed the diagnostic neuropathology of brain tumors. Diffuse gliomas, the most common and...
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A comprehensive genomic study of 390 H3F3A-mutant pediatric and adult diffuse high-grade gliomas, CNS WHO grade 4
Malignant brain tumors, known as H3K27-altered diffuse midline glioma (DMG) and H3G34-mutant diffuse hemispheric glioma (DHG), can affect individuals...
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Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma
Histone H3 mutations at amino acids 27 (H3K27M) and 34 (H3G34R) are recurrent drivers of pediatric-type high-grade glioma (pHGG). H3K27M mutations...
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Gliomas in children and adolescents: investigation of molecular alterations with a potential prognostic and therapeutic impact
PurposeGliomas represent the most frequent central nervous system (CNS) tumors in children and adolescents. However, therapeutic strategies for these...
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Spinale Raumforderung – Astrozytom vs. diffuses Mittelliniengliom
Due to the new WHO Classification 2021, primary brain tumors are classified based not only on histology but also on molecular genetic testing. We...
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The Evolving Classification of Diffuse Gliomas: World Health Organization Updates for 2021
Purpose of ReviewThe upcoming 2021 World Health Organization (WHO) Classification of Tumours of the Central Nervous System will feature numerous...
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Molecular neuropathology: an essential and evolving toolbox for the diagnosis and clinical management of central nervous system tumors
Molecular profiling has transformed the diagnostic workflow of CNS tumors during the last years. The latest WHO classification of CNS tumors (5th...
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Alternative lengthening of telomeres in molecular subgroups of paediatric high-grade glioma
PurposeThe maintenance of telomere length prevents cancer cell senescence and occurs via two mutually exclusive mechanisms: (a) reactivation of...
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Diffuse intrinsic pontine gliomas in pediatric patients: management updates
BackgroundThis review explores how diffuse intrinsic pontine glioma (DIPG) diagnosis and treatment have evolved and are improving.
Main body ...
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Assessment of Ki-67 expression levels in IDH-wildtype glioblastoma using logistic regression modelling of VASARI features
To investigate the value of using VASARI signs preoperatively to assess Ki-67 proliferation index levels in patients with IDH-wildtype glioblastoma...
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H3 G34-mutant high-grade glioma
H3F3A G34 ( H3.3 G34)-mutant high-grade gliomas (HGG) are rare, and newly recognized infiltrating gliomas of the cerebral hemisphere. Here, we report...
