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Efficacy and Tolerability of Adjunctive Brivaracetam in Patients with Focal-Onset Seizures on Specific Concomitant Antiseizure Medications: Pooled Analysis of Double-Blind, Placebo-Controlled Trials
IntroductionThis article aimed to assess the efficacy and tolerability of adjunctive brivaracetam (BRV) in adults with focal-onset seizures on...
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Effect of Cenobamate on Cognition in Patients with Drug-Resistant Epilepsy with Focal Onset Seizures: An Exploratory Study
Background and ObjectiveMost second and third generation antiseizure medications (ASMs) are associated with cognitive adverse events, which are a...
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Effectiveness and Safety of Adjunctive Cenobamate in People with Focal-Onset Epilepsy: Evidence from the First Interim Analysis of the BLESS Study
IntroductionDespite new anti-seizure medications (ASMs) being introduced into clinical practice, about one-third of people with epilepsy do not reach...
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Third-Generation Antiseizure Medications for Adjunctive Treatment of Focal-Onset Seizures in Adults: A Systematic Review and Network Meta-analysis
BackgroundBrivaracetam (BRV), cenobamate (CNB), eslicarbazepine acetate (ESL), lacosamide (LCM) and perampanel (PER) are antiseizure medications...
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Absence seizures in lesion-related epilepsy
BackgroundIn the new International League Against Epilepsy (ILAE) classification of seizure types, generalized seizures such as absence seizures...
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Stroke-related early seizures: clinical and neurophysiological study in a sample of Egyptian population
BackgroundAvailable data collected from patients of different types of acute cerebrovascular strokes can detect risk factors, clinical data...
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Eslicarbazepine Acetate: A Review in Focal-Onset Seizures
Eslicarbazepine acetate (Zebinix ® ), a voltage-gated sodium channel blocker, is a once-daily, orally administered anti-seizure medication available in...
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Treatment of Seizures in the Neonate: Special Report From the ILAE Task Force on Neonatal Seizures, 2022
The International League Against Epilepsy (ILAE) task force on neonatal seizures has recently published draft guidelines and consensus-based...
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Vestibular seizures and spontaneous downbeat nystagmus of ganglioglioma origin: a case report
BackgroundLow-grade gangliogliomas (GGs) are typically epileptogenic intracranial neoplasms. Yet, the presentation of simplex vertiginous experience...
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Withdrawal seizures vs on-medication seizures: an intracranial EEG recording case report
BackgroundIt has long been an interesting question of whether withdrawal seizures in epileptic patients differ from habitual seizures in terms of...
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Safety and Efficacy of Ketamine Without Intubation in the Management of Refractory Seizures: A Case Series
BackgroundContinuous infusion ketamine has demonstrated efficacy in the management of refractory seizures yet does not suppress respiratory drive...
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A Prospective Longitudinal Study of the Effects of Eslicarbazepine Acetate Treatment on Bone Density and Metabolism in Patients with Focal-Onset Epilepsy
Background and objectivesEslicarbazepine acetate (ESL) is a third-generation anti-seizure medication for patients with focal-onset epilepsy. There...
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Acute Symptomatic Seizures and Risk of Seizure Recurrence in Patients with Anti-NMDAR, Anti-LGI1, and Anti-GABABR Encephalitis
AimsTo analyze the clinical characteristics of acute symptomatic seizures and predict the risk factors for seizure recurrence in patients with...
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Predictive factors for post operative seizures following meningioma resection in patients without preoperative seizures: a multicenter retrospective analysis
PurposeMeningiomas are the most common primary brain tumor and represent 35% of all intracranial neoplasms. However, in the early post-operative...
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Pregabalin for Recurrent Seizures in Critical Illness: A Promising Adjunctive Therapy, Especially for cyclic Seizures
BackgroundPregabalin (PGB) is an effective adjunctive treatment for focal epilepsy and acts by binding to the alpha2-delta subunit of voltage-gated...
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Predictors of abnormal electroencephalogram and neuroimaging in children presenting to the emergency department with new-onset afebrile seizures
BackgroundElectroencephalogram and neuroimaging in pediatric patients with new-onset afebrile seizures are performed to detect any underlying...
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Acute symptomatic seizures in newborns: a narrative review
Acute symptomatic seizures are the main sign of neurological dysfunction in newborns. This is linked to the unique characteristics of the neonatal...
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Adjunctive Cenobamate for Focal-Onset Seizures in Adults: A Systematic Review and Meta-Analysis
BackgroundCenobamate is a novel tetrazole-derived carbamate compound with a dual mechanism of action. This drug can enhance the inactivated state of...
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Modified CAVE score for predicting late seizures after intracerebral hemorrhage
Background and purposeSeizures commonly occur in patients with intracerebral hemorrhage (ICH). Anticonvulsants are commonly used for preventing...
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Neonatal seizures—diagnostic options and treatment recommendations
Seizures in neonates should prompt rapid evaluation to verify the diagnosis, determine etiology, and initiate appropriate treatment. Neonatal seizure...